DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rm62 and Tdrd12

DIOPT Version :9

Sequence 1:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_038956788.1	Gene:	Tdrd12 / 689639	RGDID:	1562792	Length:	1314	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	101/467 - (21%)
Similarity:	190/467 - (40%)	Gaps:	70/467 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 PMRPVDFSNLAPFKKNFYQEHPNVANRSPYEVQRYREEQEITVRGQVPNPIQDFSEVHLPDYVMK 294
            |:|..:.|:|...:|      ..:....|..|.|.|.|           |.....:..|...:.|
  Rat   388 PLRADEISDLHQLQK------VKLGTLQPGVVLRNRIE-----------PCLTLDKSPLSADLKK 435

  Fly   295 EIRRQGYKAPTAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRG------- 352
            .::|..:..|:...:..||....|.:.|.|:..|:...|  .||.::.|     ||.|
  Rat   436 ALQRNKFPGPSHTASYSWPPIARGCDVVVISHCGNDPLL--YLPPLLTI-----LQMGGCYKSLP 493

  Fly   353 --DGPIALVLAPTRELAQQIQQVATEFGSSSYVRNTCV--FGGAPKGGQMRDLQRGCEIVIATPG 413
              :||:|:::.|..:.||.|.::..::..||...:..:  .|......:...|.|||::::.||.
  Rat   494 SRNGPLAVIVCPGWKKAQFIFELLGDYSMSSRPLHPVLLTIGLHKDEAKNMKLPRGCDVIVTTPH 558

  Fly   414 RLIDFLSAGSTNLKRCTYLVLDEADRMLDMGFEPQIRKIVSQIRPD----------RQTLMWSAT 468
            .|:..|:..|....|..:|||||. .:|......|:..|:...:.:          .|.:.....
  Rat   559 SLLRLLTYRSLLFLRLCHLVLDEV-HVLFFEANEQMFAILDNFKKNVEVEERESAPHQIVAVGVH 622

  Fly   469 WPKEVKQLAEDFLGNYIQINIGSLELSANH-NIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGK 532
            |.:.::.|..:|:.: ..:.|.:||.:|.: :::|||.:|.|.   ||..|||..:........|
  Rat   623 WNRHIEHLVREFMKD-PHVVITALEEAALYGSVQQVVHLCLEC---EKTSTLLQVLDFVPSQAQK 683

  Fly   533 IIIFVETKRRVDNLVRFIRSFGVRCGAIHGDKSQSERDFVLREFR----SGKSNILVATDVAARG 593
            .:||..:....:.:.:.:.|..:.|..:|.:.:.:.:. :|.:::    ||...:|..||.....
  Rat   684 TLIFTCSVAETEIVCKVVESNSIFCLKMHKEMAFNLKS-ILEQWKKKLSSGSHIVLTLTDDCIPL 747

  Fly   594 LDVDGIKYVINFDYPQNSE----------DYIHRIGRTG----RSNTKGTSFAFFTKNNAKQAKA 644
            |.:.....|::|.:|.:.:          |:...:...|    :...|..|....|:.||..|..
  Rat   748 LAITDATCVVHFSFPSSPKVFGGRLYCMSDHFQSLTEQGSPAEQGGKKTKSVLLLTERNASHAVG 812

  Fly   645 LVDVLREANQEI 656
            ::..|..|:.:|
  Rat   813 VLRYLERADAKI 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	89/415 (21%)
		DEADc	283..488	CDD:238167	49/225 (22%)
		HELICc	499..633	CDD:238034	30/151 (20%)
Tdrd12	XP_038956788.1	Tudor_TDRD12_rpt1	13..171	CDD:410505
		SrmB	428..862	CDD:223587	90/410 (22%)
		Tudor_TDRD12_rpt2	900..1022	CDD:410506
		p23_like	1179..1254	CDD:107220
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810