DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rm62 and DDX43

DIOPT Version :9

Sequence 1:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_061135.2	Gene:	DDX43 / 55510	HGNCID:	18677	Length:	648	Species:	Homo sapiens

Alignment Length:	451	Identity:	183/451 - (40%)
Similarity:	279/451 - (61%)	Gaps:	21/451 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 QDLPMRPVDFSNLAPFKKNFYQEHPNVANRSPYEVQRYREEQ-EIT-------VRGQVPNPIQDF 283
            :.|..:...:::|.|.|||||:|....:..|..|...:|:|. .||       .:..:|||...|
Human   179 EGLKWQKTKWADLPPIKKNFYKESTATSAMSKVEADSWRKENFNITWDDLKDGEKRPIPNPTCTF 243

  Fly   284 SEVH--LPDYVMKEIRRQGYKAPTAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQ 346
            .:..  .|: ||:.|::.|::.||.||:|.|||.:.|.:.:|:|:||:||||.|::|..:|:..|
Human   244 DDAFQCYPE-VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQ 307

  Fly   347 QPLQ-RGDGPIALVLAPTRELAQQIQQVATEFGSSSY--VRNTCVFGGAPKGGQMRDLQRGCEIV 408
            ..|: :.:.|..|||.||||||.|::....::   ||  :|:.||:||..:..|:.:|::|.:|:
Human   308 PSLKGQRNRPGMLVLTPTRELALQVEGECCKY---SYKGLRSVCVYGGGNRDEQIEELKKGVDII 369

  Fly   409 IATPGRLIDFLSAGSTNLKRCTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEV 473
            |||||||.|...:...|||..|||||||||:||||||||||.||:..:||||||:|.|||||..|
Human   370 IATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSV 434

  Fly   474 KQLAEDFLGNYIQINIGSLELSANHNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVE 538
            .:||:.:|...:.:.:|:|:|.|..:::|.:.|..|..|...::|.|..:..|.    |:|:||.
Human   435 HRLAQSYLKEPMIVYVGTLDLVAVSSVKQNIIVTTEEEKWSHMQTFLQSMSSTD----KVIVFVS 495

  Fly   539 TKRRVDNLVRFIRSFGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVI 603
            .|...|:|...:....:...::|||:.|.:|:..|..|::||..||:|||:|:|||||..:.:|.
Human   496 RKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVY 560

  Fly   604 NFDYPQNSEDYIHRIGRTGRSNTKGTSFAFFTKNNAKQAKALVDVLREANQEINPALENLA 664
            |||:|:|.|:|:||||||||:...|.|....|:|:.:.|..|:::|..|||.|...|.::|
Human   561 NFDFPRNIEEYVHRIGRTGRAGRTGVSITTLTRNDWRVASELINILERANQSIPEELVSMA 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	162/380 (43%)
		DEADc	283..488	CDD:238167	98/209 (47%)
		HELICc	499..633	CDD:238034	52/133 (39%)
DDX43	NP_061135.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60
		KH-I	76..128	CDD:238053
		PTZ00424	241..622	CDD:185609	165/389 (42%)
		Q motif	242..270		9/28 (32%)
		DEADc	251..448	CDD:238167	97/200 (49%)
		DEAD box	396..399		2/2 (100%)
		HELICc	461..589	CDD:238034	52/131 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	628..648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S387
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860