Protein Alignment Rm62 and DDX4

DIOPT Version :10

• Sequence 1: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: NP_077726.1
• Gene: DDX4 / 54514
• HGNCID: 18700
• Length: 724
• Species: Homo sapiens
• Alignment Length: 742
• Identity: 231/742 - (31%)
• Similarity: 344/742 - (46%)
• Gaps: 138/742 - (18%)

  Fly    31 SPRSGASSEKCITQRRHFLFSSASSSGTFASSSSLCTEQRQQFHGSRRNRETILFPSTYSSLQAQ 95
            :|.|.:..:...::|.||:.|..:|...|.:..:          |....|:.......:...::.
Human    37 TPASSSEMDDGPSRRDHFMKSGFASGRNFGNRDA----------GECNKRDNTSTMGGFGVGKSF 91

  Fly    96 SQRAFRDSSKPDSDD---YVDSIPKAEQR-TRTRKSLFNDPDERTEEIKIEGVMAPHDRDFGHSG 156
            ..|.|.:|...|.|.   :.:|....|.. ||.|                           |.|.
Human    92 GNRGFSNSRFEDGDSSGFWRESSNDCEDNPTRNR---------------------------GFSK 129

  Fly   157 RGG-RGG---DRGGDDRRGGGG------GGNRFGGGGGGGD--------------------YHGI 191
            ||| |.|   :..|..||||.|      ||  ||.|....|                    ..|.
Human   130 RGGYRDGNNSEASGPYRRGGRGSFRGCRGG--FGLGSPNNDLDPDECMQRTGGLFGSRRPVLSGT 192

  Fly   192 RNGRVEKRRDDRGGGNRFGGGGGFGDR--RGGG---------GGGSQDL---------PMRPVDF 236
            .||...:.|.  |.|:..||..|..:.  .|.|         ||.|.|.         |..|.|
Human   193 GNGDTSQSRS--GSGSERGGYKGLNEEVITGSGKNSWKSEAEGGESSDTQGPKVTYIPPPPPED- 254

  Fly   237 SNLAPFKKNFYQEHPNVANRSPYEVQRYREEQEITVRG-QVPNPIQDFSEVHLPDYVMKEIRRQG 300
                  :.:.:..:....|...|:...      :.|.| ..|..|..|.|.:|...:...|.:.|
Human   255 ------EDSIFAHYQTGINFDKYDTIL------VEVSGHDAPPAILTFEEANLCQTLNNNIAKAG 307

  Fly   301 YKAPTAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQ-------QPLQRGDGPIAL 358
            |...|.:|....||.::|.:.:..|:||||||..::||.:.|:.:.       :.||.   |..:
Human   308 YTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQE---PECI 369

  Fly   359 VLAPTRELAQQIQQVATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGS 423
            ::||||||..||...|.:|...:.||...::||...|..:|.:.:||.|:.||||||:|.:....
Human   370 IVAPTRELVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEK 434

  Fly   424 TNLKRCTYLVLDEADRMLDMGFEPQIRKIVS----QIRPDRQTLMWSATWPKEVKQLAEDFL-GN 483
            ..||:..|||||||||||||||.|:::|::|    ..:..|||||:|||:|:|:::||.:|| .|
Human   435 IGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLKSN 499

  Fly   484 YIQINIGSLELSANHNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVR 548
            |:.:.:|.:. .|..:::|.|....:|||.|||..:|.:|.|.     :.::|||||::.|.:..
Human   500 YLFVAVGQVG-GACRDVQQTVLQVGQFSKREKLVEILRNIGDE-----RTMVFVETKKKADFIAT 558

  Fly   549 FIRSFGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSED 613
            |:....:...:||||:.|.||:..|.:||.||..:||||.|||||||::.:::|||||.|...::
Human   559 FLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDE 623

  Fly   614 YIHRIGRTGRSNTKGTSFAFF-TKNNAKQAKALVDVLREANQEINPALENLARNSRYDGGGGRSR 677
            |:||||||||....|.:.:|| .:::...|:.||.||.:|.|::...||.:|.::...|..|.:|
Human   624 YVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQDVPAWLEEIAFSTYIPGFSGSTR 688

  Fly   678 YGGGGGGGRFGGGGFKKG-SLSNGRGF 703
                  |..|.....:|| |..|..||
Human   689 ------GNVFASVDTRKGKSTLNTAGF 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	DEAD-like_helicase_N	231..669	CDD:475120	165/451 (37%)
DDX4	NP_077726.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..246		54/249 (22%)
		Interaction with RANBP9. /evidence=ECO:0000269|PubMed:27622290	228..247		4/18 (22%)
		DEADc_DDX4	257..509	CDD:350810	93/260 (36%)
		Q motif	288..316		7/27 (26%)
		DEAD box. /evidence=ECO:0000250|UniProtKB:Q61496	446..449		2/2 (100%)
		SF2_C_DEAD	515..644	CDD:350174	57/133 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..724		3/6 (50%)