DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rm62 and ddx5

DIOPT Version :9

Sequence 1:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_989229.1	Gene:	ddx5 / 394837	XenbaseID:	XB-GENE-1009995	Length:	609	Species:	Xenopus tropicalis

Alignment Length:	528	Identity:	313/528 - (59%)
Similarity:	373/528 - (70%)	Gaps:	22/528 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 RRDDRGGGNRFGGGGGFGDRRGGG----GGGSQDLPMRPVDFSNLAPFKKNFYQEHPNVANRSPY 259
            |..|||    ||||..||..|||.    |...:.|..:..:...|..|:||||||||:|..|:|.
Frog     9 RARDRG----FGGGPRFGGNRGGTSGKYGNPGERLMKKKWNLDELPKFEKNFYQEHPDVVRRTPQ 69

  Fly   260 EVQRYREEQEITVRG-QVPNPIQDFSEVHLPDYVMKEIRRQGYKAPTAIQAQGWPIAMSGSNFVG 323
            |..:||..:|||||| ..|.|:..|.|...|..:|:.::||.:..||.||.||||:|:||.:.||
Frog    70 ECDQYRRSKEITVRGLNCPKPVLQFHEASFPANLMEVVKRQNFTDPTPIQGQGWPVALSGLDMVG 134

  Fly   324 IAKTGSGKTLGYILPAIVHINNQQPLQRGDGPIALVLAPTRELAQQIQQVATEFGSSSYVRNTCV 388
            :|.|||||||.|:||.|||||:|..||||||||.||||||||||||:||||.|:|.:..:|:||:
Frog   135 VAMTGSGKTLSYLLPGIVHINHQPFLQRGDGPILLVLAPTRELAQQVQQVAAEYGRACRLRSTCI 199

  Fly   389 FGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTYLVLDEADRMLDMGFEPQIRKIV 453
            :||||||.|:|||:||.||.|||||||||||.||.|||.||||||||||||||||||||||||||
Frog   200 YGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLNRCTYLVLDEADRMLDMGFEPQIRKIV 264

  Fly   454 SQIRPDRQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSANHNIRQVVDVCDEFSKEEKLKT 518
            .|||||||||||||||||||:|||||||.:|:.||||:|||||||||.|:||||::..|:|||..
Frog   265 DQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVHINIGALELSANHNILQIVDVCNDGEKDEKLVR 329

  Fly   519 LLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHGDKSQSERDFVLREFRSGKSNI 583
            |:.:|  .||...|.|:|||||||.|:|.|.:|..|.....|||||||.|||:||.||:.|||.|
Frog   330 LMEEI--MSEKENKTIVFVETKRRCDDLTRRLRRDGWPAMGIHGDKSQQERDWVLNEFKHGKSPI 392

  Fly   584 LVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSNTKGTSFAFFTKNNAKQAKALVDV 648
            |:|||||:|||||:.:|:|||:|||.:|||||||||||.||:..||::.|||..|.||...|:.|
Frog   393 LIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSSKTGTAYTFFTPGNIKQVNDLISV 457

  Fly   649 LREANQEINPALENLARN-SRYDGGGG----RSRYGGGGGGG------RFGGGGFKKGSLSNGRG 702
            ||||||.|||.|..|..: .|:.|.||    |.|:..|..||      ..|.||.:.....:..|
Frog   458 LREANQAINPKLLQLVEDRGRFRGRGGMNDRRDRFSSGKRGGWDRENYDRGFGGKRDFGNKSQNG 522

  Fly   703 FGGGGGGG 710
            ||.....|
Frog   523 FGNKSQNG 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	253/375 (67%)
		DEADc	283..488	CDD:238167	148/204 (73%)
		HELICc	499..633	CDD:238034	80/133 (60%)
ddx5	NP_989229.1	DEADc	94..299	CDD:238167	148/204 (73%)
		DEXDc	107..314	CDD:214692	157/206 (76%)
		HELICc	310..442	CDD:238034	80/133 (60%)
		P68HR	493..521	CDD:285323	6/27 (22%)
		P68HR	545..576	CDD:285323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1549
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R290
SonicParanoid	1	1.000	-	-		X504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030