DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rm62 and Ddx50

DIOPT Version :9

Sequence 1:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001013216.2	Gene:	Ddx50 / 361848	RGDID:	1310934	Length:	734	Species:	Rattus norvegicus

Alignment Length:	698	Identity:	181/698 - (25%)
Similarity:	274/698 - (39%)	Gaps:	206/698 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 EKRRDDRGGGNRFGG--GGGFGDRRGGGGGGSQDLPMRPVDFSNLAPFKKNFYQEHPNVANRSPY 259
            ||...|...|.||..  ......||       :|||...||          .|::.....:.|..
  Rat    68 EKLNGDTKEGLRFSDEFSPSHKSRR-------KDLPNGDVD----------EYEKRSKRVSSSEN 115

  Fly   260 EVQRYREEQEITVRGQVPNPIQDFSEVHLPDYVMKEIRRQG--YKAPTAIQAQGWPIAMSGSNFV 322
            ..:...:..|...|.|......:||   :.:..:|.::.:|  |..|..::..| |: ..|.:.:
  Rat   116 SHKSSDKADETLTREQKEGAFSNFS---ISEETIKLLKGRGVTYLFPIQVKTFG-PV-YEGKDLI 175

  Fly   323 GIAKTGSGKTLGYILPAIVHI-NNQQPLQRGDGPIALVLAPTRELAQQIQQVATEFGSSSYVRN- 385
            ..|:||:|||..:.:|.|..: .||:.:::...|..||||||||||   .|||.:|...:...|
  Rat   176 AQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELA---NQVAKDFKDITRKLNV 237

  Fly   386 TCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTYLVLDEADRMLDMGFEPQIR 450
            .|.:||.....|:..::.|.:|::.||||:.|.|.:|..:|.:..::||||.|:|||:||..|:.
  Rat   238 ACFYGGTSYQSQINQIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVE 302

  Fly   451 KIV-----SQIRPDRQTLMWSATWPKEVKQLAEDFL-GNYIQIN-IGSLELSANHNIRQVVDVCD 508
            .|:     |....:.|||::|||.|:.|.::|:.:: ..|.|:: :|.:...|...:..:...|.
  Rat   303 DIIHESYKSDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCH 367

  Fly   509 EFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVR--FIRSFGVRCGAIHGDKSQSERDF 571
            ...:...:..:| .:|..||  |:.|||.|||:.|..:..  .|:. ..:|  :|||.:||:|:.
  Rat   368 WSQRPAVIGDVL-QVYSGSE--GRAIIFCETKKNVTEMAMNPHIKQ-NAQC--LHGDIAQSQREI 426

  Fly   572 VLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSNTKGTSFAFF-- 634
            .|:.||.|...:||||:|||||||:..:..||....||:.|.||||.|||||:...|....|:
  Rat   427 TLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICVCFYQP 491

  Fly   635 ----------------------------TKNNAKQA-------------------------KALV 646
                                        .|:.:..|                         |..|
  Rat   492 RERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAV 556

  Fly   647 DVL-------------------------------------------REANQEIN----------- 657
            |.|                                           :|.|::::
  Rat   557 DALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSQVTRMC 621

  Fly   658 -------------------------------------PALE-----NLARNSRYDGG--GGRS-- 676
                                                 |.:|     |.:.|.|...|  ||||
  Rat   622 LLKGNMGVCFDVPTSESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNPRQRSGWSGGRSGR 686

  Fly   677 --RYGG--GGGGGRFGGGGFKKGSLSNGRGFGGGGGGGGEGRHSR-FD 719
              |.||  ||..||....|.:.||..:||...|.......|.|.| ||
  Rat   687 SGRSGGRSGGRSGRQSRQGSRSGSRQDGRRRSGNRNRSRSGGHKRSFD 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	135/486 (28%)
		DEADc	283..488	CDD:238167	73/214 (34%)
		HELICc	499..633	CDD:238034	51/135 (38%)
Ddx50	NP_001013216.2	SrmB	130..608	CDD:223587	136/491 (28%)
		DEADc	136..339	CDD:238167	71/210 (34%)
		HELICc	369..486	CDD:238034	50/122 (41%)
		GUCT_RHII_Gualpha_beta	565..656	CDD:240593	2/90 (2%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820