DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rm62 and CG8611

DIOPT Version :9

Sequence 1:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	678	Identity:	171/678 - (25%)
Similarity:	274/678 - (40%)	Gaps:	194/678 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 QAQSQRAFRDSSKPDSDDYVDSIPKAEQRTRTRKSLFND--PDERTEEIKIEGVMAPHDRDFGHS 155
            :.|..||.:.:.|          ||...:..|...||..  .:||.::.:.||
  Fly   161 EEQITRALKSNKK----------PKNPNQLPTPGDLFRAQLEEERRQKRREEG------------ 203

  Fly   156 GRGGRGGDRGG-----DDRRGGGGGGNRFGGGGGGGDYHGIRNGRVEKRRDDRGGGNRFGGGGGF 215
                 |||:..     |.:...|||..|.....      .::..:.....:|.|
  Fly   204 -----GGDQEASADEEDAKNNSGGGSPRVKPSS------AVKESKKSSDIEDSG----------- 246

  Fly   216 GDRRGGGGGGSQDLPMRPVDFSNLAPFKKNFYQEHPNVANRSP-----YEVQRYR-------EEQ 268
               ..|....:.|  ..|.:.|..:|.::   :|....|.:.|     ....|:|       ::.
  Fly   247 ---ESGEESATSD--EEPDESSAQSPGQE---KEPKQTAKKPPKAEETSSTNRFRTKKIGLFDQS 303

  Fly   269 EITVRGQV----PNPIQD-------FSEVHLPDYVMKEIR-RQGYKAPTAIQAQGWPIAMSGSNF 321
            ::....|:    ..|:::       .|.:.|..:.:|.:. ....:..|::|.:..|..:.|.:.
  Fly   304 DVEALKQLGQRAVKPVKETIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDV 368

  Fly   322 VGIAKTGSGKTLGYILPAIVHINNQQP-LQRGDGPIALVLAPTRELAQQ----IQQVATEFGSSS 381
            :..::|||||||.|.||.:..:..||| :||.||.:|||:.|||||..|    ||::...:
  Fly   369 LVRSQTGSGKTLAYALPLVELLQKQQPRIQRKDGVLALVIVPTRELVMQTYELIQKLVKPY---- 429

  Fly   382 YVRNTCVFGGAPKGGQMRD-----LQRGCEIVIATPGRLID-FLSAGSTNLKRCTYLVLDEADRM 440
                |.:..|:..||:.|.     |::|..|:|.|||||:| .|...|..|.:..:|:||||||:
  Fly   430 ----TWIVPGSLLGGESRKSEKARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRL 490

  Fly   441 LDMGFEPQIRKIVSQI-----------RPDRQTLMWSATWPKEVKQLA----------------- 477
            |::|:|..::::|..|           .|..|.::.|||...:|:|||
  Fly   491 LELGYERDVKQLVEAIDKQRAECEDKELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAA 555

  Fly   478 ---------------------EDFLGNYIQINIGSLELSANHNIRQVVDVCDEFSKEEKLK---- 517
                                 :|.||.|.:...|.|.:..|..:..||       ...||:
  Fly   556 SAALKSKDGYQKETIEALLEVDDGLGEYQEDVTGVLSIPENLQLSYVV-------VPPKLRLVAL 613

  Fly   518 -TLLSDIYDTSESPGKIIIFVET---------------KRRV--------------DNLVRFIRS 552
             :||:...|.|....|.|:|:.|               .|||              |..:..::
  Fly   614 SSLLAKEVDASPKQFKAIVFMSTTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQ- 677

  Fly   553 FGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHR 617
             |:|...:||..:|:||..|.|.||...|.:|:||||..||:||..||.|:.:..||.:.|::||
  Fly   678 -GLRFFKLHGSMTQTERQGVFRGFRDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHR 741

  Fly   618 IGRTGRSNTKGTSFAFFTKNNAKQAKAL 645
            :|||.|:..||.:..|.|.:.|:..:.|
  Fly   742 VGRTARAGRKGRAVLFLTPSEAQFVRHL 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	136/468 (29%)
		DEADc	283..488	CDD:238167	78/265 (29%)
		HELICc	499..633	CDD:238034	51/167 (31%)
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	19/123 (15%)
		P-loop_NTPase	332..548	CDD:304359	73/223 (33%)
		DEXDc	348..554	CDD:214692	71/213 (33%)
		HELICc	601..757	CDD:238034	51/164 (31%)
		DUF4217	805..866	CDD:290667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840