DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rm62 and Ddx42

DIOPT Version :9

Sequence 1:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_001100529.1	Gene:	Ddx42 / 303607	RGDID:	1304909	Length:	929	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	251/746 - (33%)
Similarity:	374/746 - (50%)	Gaps:	103/746 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GGATPRPTACGWGNLLLISPRSGASSEKCITQRRHFLFSSASSSGTFASSSSLCTEQRQQFH--G 75
            |..|.|  ..|:|...:   .:|...|..:.|:.|..|.:||||..|..|:   ..|...|:  |
  Rat     7 GPGTKR--GFGFGGFAI---SAGKKEEAKLPQQSHSAFGAASSSSGFGKSA---PPQLPSFYKIG 63

  Fly    76 SRRNRETILFPSTYSSLQAQSQRAFRDSSKPDSDDYVDSIPKAEQRTRTRKSLFNDP-DERTEEI 139
            |:|        :.:....|..:....|||..|    :..||  .:.:.||:...:.| |..:::.
  Rat    64 SKR--------ANFDEENAYFEDEEEDSSNVD----LPYIP--AENSPTRQQFRSKPADSDSDDD 114

  Fly   140 KIEGVMAPHDRDFGHSGRGGRGGDRGGDDRRGGGGGGNRFGGGGGGGDYHGIRN----------- 193
            .:|..||..:   ..:.|..:..:....:|:                :..|||:
  Rat   115 PLEAFMAEVE---DQAARDMKRLEEKDKERK----------------NVKGIRDDIEEEDDQEAY 160

  Fly   194 ----------GRVEKRRDDR----GGGNRFGGGGGFGDRRGGGGGGSQDLPMRPVDFSNL--APF 242
                      |.|::..:|.    ..||.........|            |:.|:|.|.:  .||
  Rat   161 FRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPSKKIID------------PLPPIDHSEIDYPPF 213

  Fly   243 KKNFYQEHPNVANRSPYEVQRYREEQEITVRGQV-PNPIQDFSEVHLPDYVMKEIRRQGYKAPTA 306
            :||||.||..:.|.:|.::...|.:..:.|.|.. |.|...|:.....:.:|.:||:..|..||.
  Rat   214 EKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTP 278

  Fly   307 IQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRGDGPIALVLAPTRELAQQIQ 371
            ||.||.|:|:||.:.:||||||||||..:|.|.::||.:|:.|:.||||||:::.|||||.|||.
  Rat   279 IQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIH 343

  Fly   372 QVATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTYLVLDE 436
            .....||.:..:|:..|:||.....|.:.||.|.|||:.|||||||.:...:|||:|.:|||.||
  Rat   344 AECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDE 408

  Fly   437 ADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSANHNIR 501
            ||||.|||||.|:|.|.|.:|||||||::|||:.|::::||.|.|.:.|::..|.:. .||.::.
  Rat   409 ADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIG-EANEDVT 472

  Fly   502 QVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHGDKSQ 566
            |:|::.  .|...|...|...:.:.:.| |.:::||..|...:.|...::..|...|.:|||..|
  Rat   473 QIVEIL--HSGPSKWNWLTRRLVEFTSS-GSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQ 534

  Fly   567 SERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSNTKGTSF 631
            |||:.|:.:|:.....:||||||||||||:..||.|||:|..::.:.:.||||||||:..||.::
  Rat   535 SERNKVILDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAY 599

  Fly   632 AFFTKNNAKQAKALVDVLREANQEINPALENLA------RNSRYDGGGGRS-RYGGGGGGGR--- 686
            ...|..::..|..||..|..|||.::..|.:||      |.||:.||.|:. ..||||.|.|
  Rat   600 TLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERP 664

  Fly   687 -FGGGGFKKGS----LSNGRGFGGGGGGGGE 712
             .|.....:||    :||...:....|..|:
  Rat   665 GLGSENSDRGSNNNVMSNYEAYKPSTGAMGD 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	164/375 (44%)
		DEADc	283..488	CDD:238167	103/204 (50%)
		HELICc	499..633	CDD:238034	50/133 (38%)
Ddx42	NP_001100529.1	PRK10590	254..678	CDD:236722	182/427 (43%)
		DEADc	255..459	CDD:238167	103/203 (51%)
		HELICc	470..601	CDD:238034	50/133 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920