Protein Alignment Rm62 and Ddx23

DIOPT Version :10

• Sequence 1: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: NP_001100263.2
• Gene: Ddx23 / 300208
• RGDID: 1308685
• Length: 819
• Species: Rattus norvegicus
• Alignment Length: 752
• Identity: 221/752 - (29%)
• Similarity: 322/752 - (42%)
• Gaps: 200/752 - (26%)

  Fly    68 EQRQQFHGSRRNRE---TILFPSTYSSLQAQSQRAFRDSSKPDSDDYVDSIPK------------ 117
            |:.:...|.||:::   :.|.|......::   |..|||.|.|.|::.|..||
  Rat    88 ERERDKDGHRRDKDRKRSSLSPGRGKDFKS---RKDRDSKKGDEDEHGDKRPKIQPLSLEELLAK 149

  Fly   118 -------------------------------------AEQRTRTRK-------SLFNDPDERTEE 138
                                                 .|:..:.||       .:..||.||...
  Rat   150 KKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQKMLEEERKKRKQFQDLGRKMLEDPQERERR 214

  Fly   139 IKIEGVMAPHDRDF-GHSGRGGRGGDRGGDDRRGGGGGGNRFGGGGGGGDYHGIRN---GRVEKR 199
            .:.|.:    :|:. |:....||...|...|:               ..:.|.|:.   |.::||
  Rat   215 ERRERM----ERETNGNEDEEGRQKIREEKDK---------------SKELHAIKERYLGGIKKR 260

  Fly   200 RDDRGGGNRFGGGGGFGDRR----------------------------GGGGGGSQDLPMRPVD- 235
            |..|          ...||:                            |.|.....||..:..:
  Rat   261 RRTR----------HLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQ 315

  Fly   236 ---FSNLAPFKKNFYQEHPNVAN----RSPYEVQR---------------------YREEQEITV 272
               :.:|...::...::....|.    |.....||                     :||:..||.
  Rat   316 SRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITT 380

  Fly   273 R-GQVPNPIQDFSEVHLPDYVMKEIRRQGYKAPTAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYI 336
            : |::||||:.:.:..||.::::.|.:.|||.||.||.|..||.:...:.:|:|:||||||..::
  Rat   381 KGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFL 445

  Fly   337 LPAIVHINNQQPLQR----GDGPIALVLAPTRELAQQIQQVATEFGSSSYVRNTCVFGGAPKGGQ 397
            :|.:|.|.....:.|    ..||.|::|||||||||||::...:||....:|...|.||..:..|
  Rat   446 IPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQ 510

  Fly   398 MRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTYLVLDEADRMLDMGFEPQIRKI-----VSQIR 457
            ...|:.||||||||||||||.|......|.||||:||||||||:||||||.::||     ||..:
  Rat   511 GFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQK 575

  Fly   458 PD---------------------RQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSANHNIR 501
            ||                     |||:|::||.|..|::||..:|.....:.|||.. ..:..:.
  Rat   576 PDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAG-KPHERVE 639

  Fly   502 QVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHGDKSQ 566
            |.|.:..|..|.:||..:|...:|.     .|||||..|:..|.|.:.:...|.....:||.|.|
  Rat   640 QKVFLMSESEKRKKLLAILEQGFDP-----PIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQ 699

  Fly   567 SERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSNTKGTSF 631
            .:|:|.|...::|..:||||||||.||:|:..:..|:|:|..:|.||||||||||||:...|.:.
  Rat   700 EQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAI 764

  Fly   632 AFFTKNNA------KQAKALVDVLREANQEINPALEN 662
            .|.||.::      |||     :|........|.|.|
  Rat   765 TFLTKEDSAVFYELKQA-----ILESPVSSCPPELAN 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	DEAD-like_helicase_N	231..669	CDD:475120	178/498 (36%)
Ddx23	NP_001100263.2	SF-CC1	79..>207	CDD:273721	19/121 (16%)
		SrmB	391..782	CDD:440279	160/401 (40%)