Protein Alignment Rm62 and DDX25

DIOPT Version :10

• Sequence 1: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: NP_037396.3
• Gene: DDX25 / 29118
• HGNCID: 18698
• Length: 483
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 129/484 - (26%)
• Similarity: 215/484 - (44%)
• Gaps: 66/484 - (13%)

  Fly   221 GGGGGSQDLPMRPVDFSNLAPFKKNFYQEHPNVANRSPYEVQRYREEQEITVRGQVPN------- 278
            ||..|:.:.......||||:..:||.:.............:....|:.|..|.....|
Human     7 GGDAGAAESERLNSHFSNLSQPRKNLWGIKSTAVRNIDGSINNINEDDEEDVVDLAANSLLNKLI 71

  Fly   279 -----------------------PIQDFSEVHLPDYVMKEIRRQGYKAPTAIQAQGWP--IAMSG 318
                                   .::.|.|:.|.:.::|.|...|:..|:.||....|  :|...
Human    72 HQSLVESSHRVEVLQKDPSSPLYSVKTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLAHPP 136

  Fly   319 SNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRGDGPIALVLAPTRELAQQIQQVATEFGSSSY- 382
            .|.:..:::|:|||..::|..:..:|..:..     |..|.||||.|||.|..:|..:.|....
Human   137 QNLIAQSQSGTGKTAAFVLAMLSRVNALELF-----PQCLCLAPTYELALQTGRVVEQMGKFCVD 196

  Fly   383 ------VRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDF-LSAGSTNLKRCTYLVLDEADRM 440
                  :|...:    |:|   .|:.:  :|:|.|||.::|: ......:|.:....||||||.|
Human   197 VQVMYAIRGNRI----PRG---TDITK--QIIIGTPGTVLDWCFKLKLIDLTKIRVFVLDEADVM 252

  Fly   441 LD-MGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFLGNYIQINIGSLELSANHNIRQVV 504
            :| .||.....:|...:..:.|.|::|||:...|...||..:.:...|.:...||:.| ||||..
Human   253 IDTQGFSDHSIRIQRALPSECQMLLFSATFEDSVWHFAERIIPDPNVIKLRKEELTLN-NIRQYY 316

  Fly   505 DVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHGDKSQSER 569
            .:|:.  :::|.:. |.:||. |.:.|:.|||.:|:|....|...:...|.:...:.|:.:..:|
Human   317 VLCEH--RKDKYQA-LCNIYG-SITIGQAIIFCQTRRNAKWLTVEMIQDGHQVSLLSGELTVEQR 377

  Fly   570 DFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYP------QNSEDYIHRIGRTGRSNTKG 628
            ..:::.||.||..:|:.|:|.|||:||..:..|:|||.|      .:.|.|:||||||||...||
Human   378 ASIIQRFRDGKEKVLITTNVCARGIDVKQVTIVVNFDLPVKQGEEPDYETYLHRIGRTGRFGKKG 442

  Fly   629 TSFAFFTKNNAKQAKALVDVLREANQEIN 657
            .:|.....:.......:.|....:.:::|
Human   443 LAFNMIEVDELPSLMKIQDHFNSSIKQLN 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	DEAD-like_helicase_N	231..669	CDD:475120	126/474 (27%)
DDX25	NP_037396.3	Nuclear export signal. /evidence=ECO:0000250	61..74		1/12 (8%)
		DEADc_DDX25	80..308	CDD:350806	62/241 (26%)
		Q motif	97..125		8/27 (30%)
		Nuclear localization signal. /evidence=ECO:0000250	100..114		4/13 (31%)
		DEAD box	247..250		2/2 (100%)
		SF2_C_DEAD	312..448	CDD:350174	49/139 (35%)