Protein Alignment Rm62 and DDX5

DIOPT Version :9

• Sequence 1: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: NP_001307524.1
• Gene: DDX5 / 1655
• HGNCID: 2746
• Length: 614
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 316/556 - (56%)
• Similarity: 377/556 - (67%)
• Gaps: 56/556 - (10%)

  Fly   153 GHSGRGGRGGDRGGDDRRGGGGGGNRFGGGGGGGDYHGIRNGRVEKRRDDRGGGNRFGGGGGFGD 217
            |:|....||.||        |.|..||||.         |.|.:        .|.:||..|
Human     3 GYSSDRDRGRDR--------GFGAPRFGGS---------RAGPL--------SGKKFGNPG---- 38

  Fly   218 RRGGGGGGSQDLPMRPVDFSNLAPFKKNFYQEHPNVANRSPYEVQRYREEQEITVRG-QVPNPIQ 281
                     :.|..:..:...|..|:||||||||::|.|:..||:.||..:|||||| ..|.|:.
Human    39 ---------EKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVL 94

  Fly   282 DFSEVHLPDYVMKEIRRQGYKAPTAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQ 346
            :|.|.:.|..||..|.||.:..||||||||||:|:||.:.||:|:|||||||.|:||||||||:|
Human    95 NFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQ 159

  Fly   347 QPLQRGDGPIALVLAPTRELAQQIQQVATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIAT 411
            ..|:||||||.||||||||||||:||||.|:..:..:::||::||||||.|:|||:||.||.|||
Human   160 PFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIAT 224

  Fly   412 PGRLIDFLSAGSTNLKRCTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQL 476
            ||||||||..|.|||:|.||||||||||||||||||||||||.|||||||||||||||||||:||
Human   225 PGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQL 289

  Fly   477 AEDFLGNYIQINIGSLELSANHNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKR 541
            |||||.:||.||||:|||||||||.|:||||.:..|:|||..|:.:|  .||...|.|:||||||
Human   290 AEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEI--MSEKENKTIVFVETKR 352

  Fly   542 RVDNLVRFIRSFGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFD 606
            |.|.|.|.:|..|.....|||||||.|||:||.||:.||:.||:|||||:|||||:.:|:|||:|
Human   353 RCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYD 417

  Fly   607 YPQNSEDYIHRIGRTGRSNTKGTSFAFFTKNNAKQAKALVDVLREANQEINPALENLARNSRYDG 671
            ||.:|||||||||||.||...||::.|||.||.||...|:.|||||||.|||.|..|..    |.
Human   418 YPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVE----DR 478

  Fly   672 GGGRSRYGGGGGG------GRFGGGGFKKGSLSNGR 701
            |.||||   |.||      .|:..|  |:|..:..|
Human   479 GSGRSR---GRGGMKDDRRDRYSAG--KRGGFNTFR 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	254/375 (68%)
		DEADc	283..488	CDD:238167	149/204 (73%)
		HELICc	499..633	CDD:238034	79/133 (59%)
DDX5	NP_001307524.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		18/73 (25%)
		PTZ00110	6..507	CDD:240273	313/549 (57%)
		Q motif	94..122		12/27 (44%)
		DEAD box	248..251		2/2 (100%)
		Transactivation domain	477..614		14/38 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..504		12/31 (39%)
		P68HR	498..532	CDD:400414	4/14 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1590
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100364
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R290
SonicParanoid	1	1.000	-	-		X504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.710