Protein Alignment Rm62 and Ddx4

DIOPT Version :10

• Sequence 1: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: XP_011242920.1
• Gene: Ddx4 / 13206
• MGIID: 102670
• Length: 738
• Species: Mus musculus
• Alignment Length: 704
• Identity: 216/704 - (30%)
• Similarity: 321/704 - (45%)
• Gaps: 143/704 - (20%)

  Fly   105 KPDSDDYVDSIPKAEQRTRTRKSLFNDPDERTEEIKIEGVMAPHD-------------------- 149
            ||....||....|.:..:......||    ||....:...:...|
Mouse    12 KPHVSSYVPVFEKDKYSSGANGDTFN----RTSASSVLFALEMEDGPSGRDDFMRSGFPSGRSLG 72

  Fly   150 -RDFGHS------------GRGGRGGDRG------------------------------GDDRRG 171
             ||.|.|            |||...|:||                              |..:||
Mouse    73 SRDIGESSKKENTSTTGGFGRGKGFGNRGFLNNKFEEGDSSGFWKESNNDCEDNQTRSRGFSKRG 137

  Fly   172 GGGGGNRFGGG-----GGGGDYHGIRN----GRVEKRRDDRGGGNRFGGGGGFGDRR-------- 219
            |...||.....     ||.|.:.|.|.    ||.....|...|..|  |||.||.|:
Mouse   138 GCQDGNDSEASGPFRRGGRGSFRGCRGGFGLGRPNSESDQDQGTQR--GGGLFGSRKPAASDSVQ 200

  Fly   220 -------------GGGGGGSQDLPMRPVDFSNLAPFK------KNFYQEHPNVANRSP------- 258
                         |.|.||.:.|....|..|....:|      ::...:.|.|....|
Mouse   201 CLTGNGDTYQSRSGSGRGGYKGLNEEVVTGSGKNSWKSETEGGESSDSQGPKVTYIPPPPPEDED 265

  Fly   259 -----YEVQRYREEQE---ITVRG-QVPNPIQDFSEVHLPDYVMKEIRRQGYKAPTAIQAQGWPI 314
                 |:.....::.:   :.|.| ..|..|..|.|.:|...:...|.:.||...|.:|....||
Mouse   266 SIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPI 330

  Fly   315 AMSGSNFVGIAKTGSGKTLGYILPAIVHI-------NNQQPLQRGDGPIALVLAPTRELAQQIQQ 372
            .::|.:.:..|:||||||..::||.:.|:       :..:.||.   |..:::||||||..||..
Mouse   331 VLAGRDLMACAQTGSGKTAAFLLPILAHMMRDGITASRFKELQE---PECIIVAPTRELINQIYL 392

  Fly   373 VATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSAGSTNLKRCTYLVLDEA 437
            .|.:|...:.||...::||...|..:|.:.:||.|:.||||||:|.:......||:..|||||||
Mouse   393 EARKFSFGTCVRAVVIYGGTQFGHSVRQIVQGCNILCATPGRLMDIIGKEKIGLKQVKYLVLDEA 457

  Fly   438 DRMLDMGFEPQIRKIVS----QIRPDRQTLMWSATWPKEVKQLAEDFL-GNYIQINIGSLELSAN 497
            ||||||||.|:::|::|    ..:..||||::|||:|:|:::||.||| .:|:.:.:|.:. .|.
Mouse   458 DRMLDMGFGPEMKKLISCPGMPSKEQRQTLLFSATFPEEIQRLAGDFLKSSYLFVAVGQVG-GAC 521

  Fly   498 HNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHG 562
            .:::|.:....::||.|||..:|.:|.|.     :.::|||||::.|.:..|:....:...:|||
Mouse   522 RDVQQTILQVGQYSKREKLVEILRNIGDE-----RTMVFVETKKKADFIATFLCQEKISTTSIHG 581

  Fly   563 DKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSEDYIHRIGRTGRSNTK 627
            |:.|.||:..|.:||.||..:||||.|||||||::.:::|||||.|...::|:||||||||....
Mouse   582 DREQREREQALGDFRCGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNT 646

  Fly   628 GTSFAFF-TKNNAKQAKALVDVLREANQEINPALENLARNSRYDGGGGRSRYGG 680
            |.:.:|| |.::...|:.||.||.:|.|::...||.:|.::........|..||
Mouse   647 GRAISFFDTDSDNHLAQPLVKVLSDAQQDVPAWLEEIAFSTYVPPSFSSSTRGG 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	DEAD-like_helicase_N	231..669	CDD:475120	166/472 (35%)
Ddx4	XP_011242920.1	DEADc_DDX4	266..518	CDD:350810	91/254 (36%)
		SF2_C_DEAD	524..653	CDD:350174	55/133 (41%)