DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rm62 and Ddx3x

DIOPT Version :9

Sequence 1:NP_524243.2 Gene:Rm62 / 40739 FlyBaseID:FBgn0003261 Length:719 Species:Drosophila melanogaster
Sequence 2:NP_034158.1 Gene:Ddx3x / 13205 MGIID:103064 Length:662 Species:Mus musculus


Alignment Length:655 Identity:253/655 - (38%)
Similarity:337/655 - (51%) Gaps:106/655 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 RTRTRKSLFNDPDERTEEIKIEGVMAPHDRDFGHSGRGGRGGDRGGDDRRGGGGGGNRFGGGGGG 185
            |.|.....|.|.|.       .|..:..|:| .:|..|.||..||.....|..|.|:|       
Mouse    44 RNREATKGFYDKDS-------SGWSSSKDKD-AYSSFGSRGDSRGKSSFFGDRGSGSR------- 93

  Fly   186 GDYHGIRNGRVEKRRDDRGGGNRFGGGGGFGDRRGGG----GGGS-------QDLPMRPVDFSNL 239
                    ||.    ||||.|: :.|.||.|||.|.|    ||.|       :|      |:|..
Mouse    94 --------GRF----DDRGRGD-YDGIGGRGDRSGFGKFERGGNSRWCDKSDED------DWSKP 139

  Fly   240 APFKKNFYQEHPNVANRSPYEVQRYREEQEITVRGQVPNPIQDFSEVHLPDYVMKEIRRQGYKAP 304
            .|..:...||..:..| :....::|.:..........|..|:.||:|.:.:.:|..|....|..|
Mouse   140 LPPSERLEQELFSGGN-TGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRP 203

  Fly   305 TAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHI-------------NNQQPLQRGDGPI 356
            |.:|....||.....:.:..|:||||||..::||.:..|             .|.:..:|...||
Mouse   204 TPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYADGPGEALRAMKENGRYGRRKQYPI 268

  Fly   357 ALVLAPTRELAQQIQQVATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSA 421
            :||||||||||.||.:.|.:|...|.||...|:|||..|.|:|||:|||.:::||||||:|.:..
Mouse   269 SLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGAEIGQQIRDLERGCHLLVATPGRLVDMMER 333

  Fly   422 GSTNLKRCTYLVLDEADRMLDMGFEPQIRKIVSQ--IRPD--RQTLMWSATWPKEVKQLAEDFLG 482
            |...|..|.||||||||||||||||||||:||.|  :.|.  |.|:|:|||:|||::.||.|||.
Mouse   334 GKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLD 398

  Fly   483 NYIQINIGSLELSANHNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLV 547
            .||.:.:|.:. |.:.||.|.|...:|..|    ::.|.|:.:.:......::|||||:..|:|.
Mouse   399 EYIFLAVGRVG-STSENITQKVVWVEEIDK----RSFLLDLLNATGKDSLTLVFVETKKGADSLE 458

  Fly   548 RFIRSFGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSE 612
            .|:...|..|.:||||:||.:|:..|.:||||||.|||||.|||||||:..:|:|||||.|.:.|
Mouse   459 DFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIE 523

  Fly   613 DYIHRIGRTGRSNTKGTSFAFFTKNNAKQAKALVDVLREANQEINPALENLA------------- 664
            :|:||||||||....|.:.:||.:.|....|.|:|:|.||.||:...|||:|             
Mouse   524 EYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAFEHHYKGSSRGRS 588

  Fly   665 RNSRYDGGGG---------------------RSRYGGGGGGGR--FGGGGFKKGSLSNGRGFGGG 706
            ::||:.||.|                     .||.||||.||.  |||||:  |...|..|:||.
Mouse   589 KSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGGSRGFGGGGY--GGFYNSDGYGGN 651

  Fly   707 GGGGG 711
            ....|
Mouse   652 YNSQG 656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rm62NP_524243.2 PTZ00424 280..656 CDD:185609 179/392 (46%)
DEADc 283..488 CDD:238167 104/221 (47%)
HELICc 499..633 CDD:238034 62/133 (47%)
Ddx3xNP_034158.1 Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000250|UniProtKB:O00571 2..139 39/128 (30%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:O00571 12..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 19..144 40/133 (30%)
Interaction with EIF4E. /evidence=ECO:0000250|UniProtKB:O00571 38..44 253/655 (39%)
PTZ00110 57..580 CDD:240273 224/562 (40%)
eIF-4B 80..>172 CDD:283846 31/118 (26%)
Interaction with GSK3B. /evidence=ECO:0000250|UniProtKB:O00571 100..662 230/572 (40%)
Interaction with IKBKE. /evidence=ECO:0000250|UniProtKB:O00571 100..110 4/10 (40%)
Interaction with CHUK. /evidence=ECO:0000250|UniProtKB:O00571 139..172 5/33 (15%)
Q motif 180..208 8/27 (30%)
DEADc 182..404 CDD:238167 104/221 (47%)
Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding. /evidence=ECO:0000250|UniProtKB:O00571 250..259 1/8 (13%)
DEAD box 347..350 2/2 (100%)
Helicase_C 426..536 CDD:278689 56/113 (50%)
Interaction with NXF1. /evidence=ECO:0000250|UniProtKB:O00571 536..661 40/123 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..633 8/31 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53695
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
43.880

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