Protein Alignment Rm62 and DDX19B

DIOPT Version :10

• Sequence 1: NP_524243.2
• Gene: Rm62 / 40739
• FlyBaseID: FBgn0003261
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: NP_001350867.1
• Gene: DDX19B / 11269
• HGNCID: 2742
• Length: 484
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 132/493 - (26%)
• Similarity: 223/493 - (45%)
• Gaps: 74/493 - (15%)

  Fly   221 GGGGGSQDLPMR------PV-DFSNL-------------APFKKNFYQEHPNVANRSPYEVQRYR 265
            |..|..||..:|      || |.|||             |..|.|...|..:...:.....|...
Human     3 GAAGRVQDRALRRFPITLPVGDLSNLHLKEEKIKPDTNGAVVKTNANAEKTDEEEKEDRAAQSLL 67

  Fly   266 EE----------QEITVRGQVPN----PIQDFSEVHLPDYVMKEIRRQGYKAPTAIQAQGWPIAM 316
            .:          .::.|..:.||    .::.|.|:.|...:::.:...|:..|:.||....|:.:
Human    68 NKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLML 132

  Fly   317 S--GSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRGDGPIALVLAPTRELAQQIQQVATEFGS 379
            :  ..|.:..:::|:|||..::|..:..:   :|..:  .|..|.|:||.|||.|..:|..:.|
Human   133 AEPPQNLIAQSQSGTGKTAAFVLAMLSQV---EPANK--YPQCLCLSPTYELALQTGKVIEQMG- 191

  Fly   380 SSYVRNTCVFGGAPKGGQMRDLQRGC----EIVIATPGRLIDFLS-AGSTNLKRCTYLVLDEADR 439
            ..|......:  |.:|.:   |:||.    :|||.|||.::|:.| ....:.|:....||||||.
Human   192 KFYPELKLAY--AVRGNK---LERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADV 251

  Fly   440 ML-DMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFL--GNYIQINIGSLELSANHNIR 501
            |: ..|.:.|..:|...:..:.|.|::|||:...|.:.|:..:  .|.|::   ..|......|:
Human   252 MIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKL---KREEETLDTIK 313

  Fly   502 QVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVRFIRSFGVRCGAIHGDKSQ 566
            |...:|.  |::||.:. |.::|. :.:..:.:||..|::....|...:...|.:...:.|:...
Human   314 QYYVLCS--SRDEKFQA-LCNLYG-AITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMV 374

  Fly   567 SERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYP------QNSEDYIHRIGRTGRSN 625
            .:|..|:..||.||..:||.|:|.|||:||:.:..|||||.|      .::|.|:||||||||..
Human   375 EQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFG 439

  Fly   626 TKGTSFAFFTKNNAKQAKALVDVLREANQEINPALENL 663
            .:|.:.      |...:|..:::|....:..|..:|.|
Human   440 KRGLAV------NMVDSKHSMNILNRIQEHFNKKIERL 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	DEAD-like_helicase_N	231..669	CDD:475120	128/483 (27%)
DDX19B	NP_001350867.1	DEAD-like_helicase_N	80..308	CDD:475120	64/241 (27%)
		SF2_C_DEAD	312..448	CDD:350174	47/145 (32%)