DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rm62 and ddx46

DIOPT Version :9

Sequence 1:	NP_524243.2	Gene:	Rm62 / 40739	FlyBaseID:	FBgn0003261	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	XP_002935944.1	Gene:	ddx46 / 100145307	XenbaseID:	XB-GENE-5787809	Length:	1049	Species:	Xenopus tropicalis

Alignment Length:	486	Identity:	194/486 - (39%)
Similarity:	291/486 - (59%)	Gaps:	27/486 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 MRPVDFSNL--APFKKNFYQEHPNVANRSPYEVQRYREEQE-ITVRGQ-VPNPIQDFSEVHLPDY 291
            :.|||...:  ..::||||.|.|.:|..:..||..||.|.| |||:|: .|.||:.:.:..:...
Frog   317 LEPVDHGKIEYESYRKNFYVEVPELAKMTTEEVNSYRLELEGITVKGKNCPKPIKSWVQCGISMK 381

  Fly   292 VMKEIRRQGYKAPTAIQAQGWPIAMSGSNFVGIAKTGSGKTLGYILPAIVHINNQQPLQRGDGPI 356
            ::..:::..|:.||.||||..|..|||.:.:||||||||||:.::||...||.:|:||:.|:|||
Frog   382 ILNSLKKHAYEKPTPIQAQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRPLEEGEGPI 446

  Fly   357 ALVLAPTRELAQQIQQVATEFGSSSYVRNTCVFGGAPKGGQMRDLQRGCEIVIATPGRLIDFLSA 421
            |:::.||||||.||.:...:|..:..:|..||:||.....|:.:|:||.||::.||||:||.|:|
Frog   447 AVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAA 511

  Fly   422 GS---TNLKRCTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVKQLAEDFLGN 483
            .:   |||:|.||:||||||||.|||||||:.:|:..|||||||:|:|||:|:.::.||...|..
Frog   512 NNGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNIRPDRQTVMFSATFPRAMEALARRILSK 576

  Fly   484 YIQINIGSLELSANHNIRQVVDVCDEFSKEEKLKTLLSDIYDTSESPGKIIIFVETKRRVDNLVR 548
            .|::.:|...:..: ::.|.|.|.:|..|..||..||...    :..|.:||||:.:...|.|::
Frog   577 PIEVQVGGRSVVCS-DVEQHVIVIEEEKKFLKLLELLGHY----QEKGAVIIFVDKQEHADGLLK 636

  Fly   549 FIRSFGVRCGAIHGDKSQSERDFVLREFRSGKSNILVATDVAARGLDVDGIKYVINFDYPQNSED 613
            .:......|.::||...|.:||.::.:|::|...:||||.||||||||..:..|||:..|.:.||
Frog   637 DLMRASYPCLSLHGGIDQYDRDSIINDFKNGVCKLLVATSVAARGLDVKQLILVINYACPNHYED 701

  Fly   614 YIHRIGRTGRSNTKGTSFAFFTKNNAKQAKALVDVLREANQEINPALENL----ARNSRYDGGGG 674
            |:||.|||||:..||.:|.|.|::.|:.|..::..|..:...:...||.|    ....:.:|...
Frog   702 YVHRAGRTGRAGNKGYAFTFITEDQARYAGDIIKALELSGTAVPAELEQLWNEFKEQQKAEGKII 766

  Fly   675 RSRYGGGGGGGRFGGGGFK----KGSLSNGR 701
            :...|       |.|.|||    :.:|:|.|
Frog   767 KKTSG-------FSGKGFKFDETEQALANER 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rm62	NP_524243.2	PTZ00424	280..656	CDD:185609	159/378 (42%)
		DEADc	283..488	CDD:238167	99/207 (48%)
		HELICc	499..633	CDD:238034	53/133 (40%)
ddx46	XP_002935944.1	DEADc_DDX46	360..581	CDD:350711	105/220 (48%)
ddx46	XP_002935944.1	SrmB	367..825	CDD:223587	174/436 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010