DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2017 and HBS1

DIOPT Version :9

Sequence 1:	NP_649603.3	Gene:	CG2017 / 40733	FlyBaseID:	FBgn0037391	Length:	643	Species:	Drosophila melanogaster
Sequence 2:	NP_013010.3	Gene:	HBS1 / 853959	SGDID:	S000001792	Length:	611	Species:	Saccharomyces cerevisiae

Alignment Length:	686	Identity:	138/686 - (20%)
Similarity:	242/686 - (35%)	Gaps:	188/686 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DGFEEEPELNGNSSGGGSSSSDYETDANANECSVVSGMPTERGNLIFDFEQGMLPPEPQLGNVEY 117
            ||.::.|:.:        ...:::...|.:|..::        |.:|...:..|.......|:..
Yeast     8 DGADDMPDFH--------DEGEFDDYLNDDEYDLM--------NEVFPTLKAQLQDYQGWDNLSL 56

  Fly   118 KLKLVNPSKQRFEHLVTQMKWRLRE----------GNGEAIYEIGVSDAGYLQGLSDKDMNASLT 172
            ||.|.: :....|..:.::|..|::          .||.|             .::.|..|.|::
Yeast    57 KLALFD-NNFDLESTLAELKKTLKKKKTPKKPIAAANGSA-------------NVTQKLANISIS 107

  Fly   173 TLK---QMAHSLGASTSVLRR--------KTIAARRAVAEVLVRKIPDDQHNIEVRV-------- 218
            ..:   ::...|....|...|        ||:   :...:..|...|...|:|...|
Yeast   108 QQRPNDRLPDWLDEEESEGERNGEEANDEKTV---QRYYKTTVPTKPKKPHDISAFVKSALPHLS 169

  Fly   219 -AVLGGADAGKSTLLGVLTQDELDNGHGRARLNMFRHMHEIQSGRTSCISHETLGFDALGNVVNY 282
             .|||..|||||||:|.|..|          ||:.......:..|.|    ||:|..      ::
Yeast   170 FVVLGHVDAGKSTLMGRLLYD----------LNIVNQSQLRKLQRES----ETMGKS------SF 214

  Fly   283 KYNEMM--TAEE------ISDRSSKL------VTFMDLAGHRRYMRTTVQALSGYSPHYAMLVV- 332
            |:..:|  |.||      :|..:|..      .|.:|..|||.::...:..:|  ....|:|.|
Yeast   215 KFAWIMDQTNEERERGVTVSICTSHFSTHRANFTIVDAPGHRDFVPNAIMGIS--QADMAILCVD 277

  Fly   333 ------SAGSGCNDTTEEHLAIVRALDM-PFFVLVTKTDITSPDATVQELCNLLTTIGCRKVPFV 390
                  .:|...:..|:||:.:..:|.: ...:.:.|.|  :.|.:.|.    ...|..:.:|::
Yeast   278 CSTNAFESGFDLDGQTKEHMLLASSLGIHNLIIAMNKMD--NVDWSQQR----FEEIKSKLLPYL 336

  Fly   391 VTNTDEAISAGSNQISENIVPIFCVSNVTGTGLNLVTKFLYV-----------LSPGISNAE-KD 443
            |       ..|..:.:.|.|||   |..:|.|   |.|..|.           |...:.||. |.
Yeast   337 V-------DIGFFEDNINWVPI---SGFSGEG---VYKIEYTDEVRQWYNGPNLMSTLENAAFKI 388

  Fly   444 RLEQESCEFQVDEIFRVSDVGPVVGGLLVQGVLTENMAMKIGPLPDGSFHPVTVNTIHRNKAPCR 508
            ..|.|........:|.|.::.|       ....:.::|:..|.|..||..|....||:.::..|.
Yeast   389 SKENEGINKDDPFLFSVLEIIP-------SKKTSNDLALVSGKLESGSIQPGESLTIYPSEQSCI 446

  Fly   509 V--VRAGQSASLSFSMDQDVPTLRSGMVLL------------GDIGNSLDEPYGTFFFQAKVSVL 559
            |  ::.|.....|.:.::....::...|.|            ||:..|:|  |.: ...|:..||
Yeast   447 VDKIQVGSQQGQSTNHEETDVAIKGDFVTLKLRKAYPEDIQNGDLAASVD--YSS-IHSAQCFVL 508

  Fly   560 FHAT-----AIYVGFQTTVHIGSIRQTAVIRGIMGG------------ERLGTNDCASVMFEFVG 607
            ...|     .:..|....:.||...|.|.|:.::..            ..||:...|.|..|.:.
Yeast   509 ELTTFDMNRPLLPGTPFILFIGVKEQPARIKRLISFIDKGNTASKKKIRHLGSKQRAFVEIELIE 573

  Fly   608 HPEYV---------RPGMRILFREGTSKGIGVVTQV 634
            ...::         |.|..:|.::|.:...|.::::
Yeast   574 VKRWIPLLTAHENDRLGRVVLRKDGRTIAAGKISEI 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2017	NP_649603.3	GTPBP1	100..635	CDD:227583	131/639 (21%)
		GTPBP1_like	217..436	CDD:206728	61/260 (23%)
		GTPBP_II	450..536	CDD:293895	16/87 (18%)
		GTPBP_III	547..634	CDD:294007	21/112 (19%)
HBS1	NP_013010.3	HBS1_N	11..73	CDD:401037	11/78 (14%)
HBS1	NP_013010.3	TEF1	161..611	CDD:227581	108/500 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2520
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950