DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2017 and gtpbp1

DIOPT Version :9

Sequence 1:	NP_649603.3	Gene:	CG2017 / 40733	FlyBaseID:	FBgn0037391	Length:	643	Species:	Drosophila melanogaster
Sequence 2:	NP_001072172.1	Gene:	gtpbp1 / 594925	XenbaseID:	XB-GENE-951182	Length:	666	Species:	Xenopus tropicalis

Alignment Length:	592	Identity:	239/592 - (40%)
Similarity:	344/592 - (58%)	Gaps:	40/592 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 PELNGNSSGGGSSSSDYETDANANECSVVSGMPTERGNLIFDFEQGMLPPEPQLGNVEYKLKLVN 123
            ||.|.:.|...:|....|.|...::|| :.|.|...|....|...              ||.||:
Frog     9 PERNQSDSPVPASMFSPEPDGEDSDCS-LDGEPLRNGEADIDLTS--------------KLVLVS 58

  Fly   124 PSKQRFEHLVTQMKWRLREGNGEAIYEIGVSDAGYLQGLSDKDMNASLTTLKQMAHSLGASTSVL 188
            ||.::::.|:.|::.|:.||.||.||.||....|...||::.||.||:.|:..||..:.|...:|
Frog    59 PSAEQYDSLLRQLRDRMDEGRGETIYVIGQGSDGTEYGLNEADMEASVATVTSMAEQIIADMILL 123

  Fly   189 RRKTIAARRAVAEVLVRKIPDDQHNIEVRVAVLGGADAGKSTLLGVLTQDELDNGHGRARLNMFR 253
            |....|..: |.:.||||...|...:||||||:|..||||||||||||..|||||.|.||..:||
Frog   124 REHQEAGGK-VRDYLVRKSVGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFR 187

  Fly   254 HMHEIQSGRTSCISHETLGFDALGNVVNY--KYNEMMTAEEISDRSSKLVTFMDLAGHRRYMRTT 316
            |.|||:|||||.:.::.||||:.|.|||.  .:...:...:|.::|||::||:|||||.:|::||
Frog   188 HKHEIESGRTSSVGNDILGFDSHGQVVNKPDSHGGSLEWTKICEKSSKIITFIDLAGHEKYLKTT 252

  Fly   317 VQALSGYSPHYAMLVVSAGSGCNDTTEEHLAIVRALDMPFFVLVTKTDITSPDATVQE----LCN 377
            |..::|:.|.:.||:|.:.:|....|:|||.:..||::|.||:|||.|: .|...:||    |..
Frog   253 VFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDM-CPANILQETLKLLQR 316

  Fly   378 LLTTIGCRKVPFVVTNTDEAISAGSNQISENIVPIFCVSNVTGTGLNLVTKFLYVLSPGISNAEK 442
            ||.:.||||:|.:|.|.|:.|...||..||.:.|||.:|||||..:.|:..||.:|||..|:.
Frog   317 LLKSPGCRKIPVLVQNKDDVIVTASNFSSERMCPIFQISNVTGENMELLKMFLNLLSPRSSSR-- 379

  Fly   443 DRLEQESCEFQVDEIFRVSDVGPVVGGLLVQGVLTENMAMKIGPLPDGSFHPVTVNTIHRNKAPC 507
               |:|..|||:|:.:.|..||.||.|..::|::..|..:.:||.|.|:|..:.|.:|||.:.|.
Frog   380 ---EEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDLLLLGPDPLGNFTSIAVKSIHRKRMPV 441

  Fly   508 RVVRAGQSASLSFSMDQDVPTLRSGMVLLGDIGNSLDEPYGTFFFQAKVSVLFHATAIYVGFQTT 572
            :.||.||:||.:....:. .::|.|||::....|    |..::.|:|::.||.|.|.|...:|..
Frog   442 KEVRGGQTASFALKKIKR-SSIRKGMVMVSPRLN----PQASWEFEAEILVLHHPTTISPRYQAM 501

  Fly   573 VHIGSIRQTAVIRGIMGGERLGTNDCASVMFEFVGHPEYVRPGMRILFREGTSKGIGVVTQV--- 634
            ||.|||||||.|.. |..:.|.|.|.|:|.|.|:..|||:....|::||||.:|.:|.:|::
Frog   502 VHCGSIRQTATILS-MSRDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQS 565

  Fly   635 ---FPVN 638
               .|:|
Frog   566 TNNLPMN 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2017	NP_649603.3	GTPBP1	100..635	CDD:227583	225/546 (41%)
		GTPBP1_like	217..436	CDD:206728	110/224 (49%)
		GTPBP_II	450..536	CDD:293895	32/85 (38%)
		GTPBP_III	547..634	CDD:294007	37/86 (43%)
gtpbp1	NP_001072172.1	SelB	65..563	CDD:332589	218/510 (43%)
gtpbp1	NP_001072172.1	GTPBP1_like	151..375	CDD:206728	110/224 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62195
OrthoDB	1	1.010	-	-		D305827at33208
OrthoFinder	1	1.000	-	-		FOG0002013
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020