DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2017 and gtpbp2b

DIOPT Version :9

Sequence 1:	NP_649603.3	Gene:	CG2017 / 40733	FlyBaseID:	FBgn0037391	Length:	643	Species:	Drosophila melanogaster
Sequence 2:	NP_001338603.1	Gene:	gtpbp2b / 570143	ZFINID:	ZDB-GENE-050208-373	Length:	605	Species:	Danio rerio

Alignment Length:	597	Identity:	286/597 - (47%)
Similarity:	390/597 - (65%)	Gaps:	54/597 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 ANECSVVSGMP---------------------TERGNLIFDFEQG-------------MLPPEPQ 111
            ||.||:.|...                     |.||      ::|             .||||.:
Zfish     6 ANHCSIKSAAKPSSPQKAAESGTETAPKKKSRTRRG------KRGKRRRGKKANEPPPFLPPEAE 64

  Fly   112 LGNVEYKLKLVNPSKQRFEHLVTQMKWRLREGNGEAIYEIGVSDAGYLQGLSDKDMNASLTTLKQ 176
            .||:|||||||||::.|||||.||:||||:||.|||:|:|||.|.|.|.||:::||.|||.||::
Zfish    65 EGNIEYKLKLVNPTQYRFEHLATQLKWRLQEGRGEAVYQIGVEDNGLLVGLTEEDMKASLKTLRR 129

  Fly   177 MAHSLGASTSVLRRKTI---AARRAVAEVLVRKIPDDQHNIEVRVAVLGGADAGKSTLLGVLTQD 238
            ||..:||..::||.:.:   .|||.:|||||||:||||..:::||||||..|:|||||||||||.
Zfish   130 MAEKVGADITLLREREVDCDRARRKIAEVLVRKVPDDQQFLDLRVAVLGNVDSGKSTLLGVLTQG 194

  Fly   239 ELDNGHGRARLNMFRHMHEIQSGRTSCISHETLGFDALGNVVNYKYNEMMTAEEISDRSSKLVTF 303
            |||||.||||||:|||:||||:||||.||.|.|||::.|.|||  |::..|||||.:.|||::||
Zfish   195 ELDNGRGRARLNLFRHLHEIQTGRTSSISFEILGFNSKGEVVN--YSDSRTAEEICESSSKMITF 257

  Fly   304 MDLAGHRRYMRTTVQALSGYSPHYAMLVVSAGSGCNDTTEEHLAIVRALDMPFFVLVTKTDI--- 365
            :|||||.:|::||:..|:.|.|.:|||||.|.:|...||.|||.:..||.:|.|::|:|.|:
Zfish   258 IDLAGHYKYLKTTIFGLTSYCPDFAMLVVGANTGIAGTTREHLGLAMALKVPIFIVVSKVDLCGK 322

  Fly   366 TSPDATVQELCNLLTTIGCRKVPFVVTNTDEAISAGSN-QISENIVPIFCVSNVTGTGLNLVTKF 429
            ::.:.||::|..:|...||.|:|.||.|.|:|::|... ..|.::.|||.:|:|:|..|:|:..|
Zfish   323 STVEKTVRQLERVLKQPGCNKIPMVVANPDDAVTAAQQFAQSSSVTPIFTLSSVSGENLDLLKVF 387

  Fly   430 LYVLSPGISNAEKDRLEQESCEFQVDEIFRVSDVGPVVGGLLVQGVLTENMAMKIGPLPDGSFHP 494
            ..:|.|..::.|::.|.|:..|||||||:.|.|||.||||.|..||..|...:.:||..||.|..
Zfish   388 FNILPPLSNSKEQEELMQQLTEFQVDEIYSVPDVGTVVGGTLYSGVCREGDRLVVGPTDDGKFLR 452

  Fly   495 VTVNTIHRNKAPCRVVRAGQSASLSFSMDQDVPTLRSGMVLLGDIGNSLDEPYGTFFFQAKVSVL 559
            :.|.:||||::.|||:||||:|:|:.. :.|...||.|||::....|    |...:.|:|.:.:|
Zfish   453 LKVCSIHRNRSGCRVLRAGQAATLALG-NFDRSLLRKGMVMVSPKMN----PTICWQFEAAIVLL 512

  Fly   560 FHATAIYVGFQTTVHIGSIRQTAVIRGIMGGERLGTNDCASVMFEFVGHPEYVRPGMRILFREGT 624
            |||.....|||.|||||::||||.:..::|.|.|.|.:.|.|.|.|:.||||:|.|.::|||||.
Zfish   513 FHAKTFRRGFQVTVHIGNVRQTATVECLLGKEELRTGERAVVCFRFLKHPEYLRVGAKLLFREGV 577

  Fly   625 SKGIGVVTQVFP 636
            :||||.||.:.|
Zfish   578 TKGIGHVTHLLP 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2017	NP_649603.3	GTPBP1	100..635	CDD:227583	277/554 (50%)
		GTPBP1_like	217..436	CDD:206728	116/222 (52%)
		GTPBP_II	450..536	CDD:293895	44/85 (52%)
		GTPBP_III	547..634	CDD:294007	43/86 (50%)
gtpbp2b	NP_001338603.1	SelB	59..585	CDD:332589	274/532 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588228
Domainoid	1	1.000	142	1.000	Domainoid score	I4634
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10420
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1186
OMA	1	1.010	-	-		QHG62195
OrthoDB	1	1.010	-	-		D305827at33208
OrthoFinder	1	1.000	-	-		FOG0002013
OrthoInspector	1	1.000	-	-		oto41609
orthoMCL	1	0.900	-	-		OOG6_100969
Panther	1	1.100	-	-	O	PTHR43721
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3896
SonicParanoid	1	1.000	-	-		X5002
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	14.030