DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2017 and Gtpbp2

DIOPT Version :9

Sequence 1:	NP_649603.3	Gene:	CG2017 / 40733	FlyBaseID:	FBgn0037391	Length:	643	Species:	Drosophila melanogaster
Sequence 2:	NP_001013243.2	Gene:	Gtpbp2 / 363195	RGDID:	1306367	Length:	602	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	289/593 - (48%)
Similarity:	391/593 - (65%)	Gaps:	40/593 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 PELNGN--SSGGGSSSSDYETDANANECSVVSGMPTERGNLIFDFEQG-------MLPPEPQLGN 114
            |.:.||  :.|.|.|||          |....|......|      :|       .||||.:.||
  Rat    19 PAMGGNLKARGAGGSSS----------CGGPKGKKKNGRN------RGGKANNPPYLPPEAEDGN 67

  Fly   115 VEYKLKLVNPSKQRFEHLVTQMKWRLREGNGEAIYEIGVSDAGYLQGLSDKDMNASLTTLKQMAH 179
            :||||||||||:.|||||||||||||:||.|||:|:|||.|.|.|.||::::|.|||.||.:||.
  Rat    68 IEYKLKLVNPSQYRFEHLVTQMKWRLQEGRGEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAE 132

  Fly   180 SLGASTSVLRRKTI----AARRAVAEVLVRKIPDDQHNIEVRVAVLGGADAGKSTLLGVLTQDEL 240
            .:||..:|||.:.:    ...|.:.||||||:||:|..:::||||||..|:|||||||||||.||
  Rat   133 KVGADITVLREREVDYDSDMPRKITEVLVRKVPDNQQFLDLRVAVLGNVDSGKSTLLGVLTQGEL 197

  Fly   241 DNGHGRARLNMFRHMHEIQSGRTSCISHETLGFDALGNVVNYKYNEMMTAEEISDRSSKLVTFMD 305
            |||.||||||:|||:|||||||||.||.|.|||::.|.|||  |::..|||||.:.|||::||:|
  Rat   198 DNGRGRARLNLFRHLHEIQSGRTSSISFEILGFNSKGEVVN--YSDSRTAEEICESSSKMITFID 260

  Fly   306 LAGHRRYMRTTVQALSGYSPHYAMLVVSAGSGCNDTTEEHLAIVRALDMPFFVLVTKTDI---TS 367
            ||||.:|:.||:..|:.|.|..|:|:|||.:|...||.|||.:..||.:|||::|:|.|:   |:
  Rat   261 LAGHHKYLHTTIFGLTSYCPDCALLLVSANTGIAGTTREHLGLALALKVPFFIVVSKVDLCAKTT 325

  Fly   368 PDATVQELCNLLTTIGCRKVPFVVTNTDEAISAGSN-QISENIVPIFCVSNVTGTGLNLVTKFLY 431
            .:.||::|..:|...||.|||.:||:.|:|::|... ..|.|:.|||.:|:|:|..|:|:..||.
  Rat   326 VERTVRQLERVLKQPGCHKVPMLVTSEDDAVTAAQQFAQSPNVTPIFTLSSVSGESLDLLKVFLN 390

  Fly   432 VLSPGISNAEKDRLEQESCEFQVDEIFRVSDVGPVVGGLLVQGVLTENMAMKIGPLPDGSFHPVT 496
            :|.|..::.|::.|.|:..|||||||:.|.:||.||||.|..|:..|...:.:||..||.|..:.
  Rat   391 ILPPLTNSKEQEELMQQLTEFQVDEIYTVPEVGTVVGGTLSSGICREGDQLVVGPTDDGCFLELR 455

  Fly   497 VNTIHRNKAPCRVVRAGQSASLSFSMDQDVPTLRSGMVLLGDIGNSLDEPYGTFFFQAKVSVLFH 561
            |.:|.||::.|||:||||:|:|:.. |.|...||.|||::....|    |.....|:|::.:|||
  Rat   456 VCSIQRNRSACRVLRAGQAATLALG-DFDRALLRKGMVMVSPEMN----PTICSVFEAEIVLLFH 515

  Fly   562 ATAIYVGFQTTVHIGSIRQTAVIRGIMGGERLGTNDCASVMFEFVGHPEYVRPGMRILFREGTSK 626
            ||....|||.|||:|::|||||:..|...::|.|.:.|.|.|.|:.||||::.|.::|||||.:|
  Rat   516 ATTFRRGFQVTVHVGNVRQTAVVEKIHAKDKLRTGEKAVVRFRFLKHPEYLKVGAKLLFREGVTK 580

  Fly   627 GIGVVTQV 634
            |||.||.|
  Rat   581 GIGHVTDV 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2017	NP_649603.3	GTPBP1	100..635	CDD:227583	278/550 (51%)
		GTPBP1_like	217..436	CDD:206728	120/222 (54%)
		GTPBP_II	450..536	CDD:293895	42/85 (49%)
		GTPBP_III	547..634	CDD:294007	42/86 (49%)
Gtpbp2	NP_001013243.2	GTPBP1	59..588	CDD:227583	276/535 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346779
Domainoid	1	1.000	135	1.000	Domainoid score	I4862
eggNOG	1	0.900	-	-		E1_COG5258
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10420
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1219
OMA	1	1.010	-	-		QHG62195
OrthoDB	1	1.010	-	-		D305827at33208
OrthoFinder	1	1.000	-	-		FOG0002013
OrthoInspector	1	1.000	-	-		oto98789
orthoMCL	1	0.900	-	-		OOG6_100969
Panther	1	1.100	-	-	LDO	PTHR43721
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5002
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.860