DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2017 and cgp-1

DIOPT Version :9

Sequence 1:	NP_649603.3	Gene:	CG2017 / 40733	FlyBaseID:	FBgn0037391	Length:	643	Species:	Drosophila melanogaster
Sequence 2:	NP_503137.1	Gene:	cgp-1 / 178540	WormBaseID:	WBGene00000480	Length:	613	Species:	Caenorhabditis elegans

Alignment Length:	527	Identity:	197/527 - (37%)
Similarity:	306/527 - (58%)	Gaps:	24/527 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 LVNPSKQRFEHLVTQMKWRLREGNGEAIYEIGV----SDAGYLQGLSDKDMN-ASLTTLKQMAHS 180
            |:..:.:..|..:..::.:|.||.||.:.|:|.    :......|||::|:: |:...||.:...
Worm    40 LLRSTPEDVEKYMIHVRKQLMEGEGECLVELGAPINSNSKNPKSGLSEEDLDKAADAQLKILEKI 104

  Fly   181 LGASTSVLRRKTIAARRAVAEV-LVRKIPDDQHNIEVRVAVLGGADAGKSTLLGVLTQDELDNGH 244
            ....|.|:|||.........|| ::|..|.::..||.||||:|..||||||||||||...||:|.
Worm   105 PAVGTKVIRRKQTGGGSLFTEVWIIRDPPTEKDFIEARVAVVGNVDAGKSTLLGVLTHSALDDGR 169

  Fly   245 GRARLNMFRHMHEIQSGRTSCISHETLGFDALGNVVNY--KYNEMMTAEEISDRSSKLVTFMDLA 307
            |.||..:|||.||.:|||||.:.::.||||..||:||.  .:|..:...:|....:|||||:|||
Worm   170 GAARTKLFRHKHEFESGRTSSVGNDILGFDVHGNIVNKPDPHNHNLDWVQIGSDCAKLVTFIDLA 234

  Fly   308 GHRRYMRTTVQALSGYSPHYAMLVVSAGSGCNDTTEEHLAIVRALDMPFFVLVTKTDITSPDATV 372
            ||.:|::||:..::|:.|.|.||::.|..|...||:|||::..:|.:|.:::|||.|:...:...
Worm   235 GHEKYLKTTIFGMTGHMPDYTMLMIGANMGIIGTTKEHLSLALSLHVPVYLVVTKIDMCPANILE 299

  Fly   373 QELCNLLTTI-GCRKVPFVVTNTDEAISAGSNQISENIVPIFCVSNVTGTGLNLVTKFLYVLSPG 436
            :.:.|:...: ..:|:|.:|.|.|:.:.|..|..|:.:.|||.||||.||.|.|:.:||.::.
Worm   300 ETMKNITRLVRSAKKLPILVRNMDDVVHAAVNFPSKKVCPIFQVSNVEGTNLPLLRQFLNIVP-- 362

  Fly   437 ISNAEKDRLEQESCEFQVDEIFRVSDVGPVVGGLLVQGVLTENMAMKIGPLPDGSFHPVTVNTIH 501
               ..:...|.:...||:|:|:.|..||.:..|.|:.|.:..|..:.:||..:|.|.|:.:.:||
Worm   363 ---LRRQLNENDPAHFQIDDIYWVDGVGTIASGTLLSGTIRLNDILLLGPTSNGDFMPIPIKSIH 424

  Fly   502 RNKAPCRVVRAGQSASLSFSMDQDVP--TLRSGMVLLGDIGNSLDEPYGTFFFQAKVSVLFHATA 564
            |.:.|..:|:.|||||.:.   :.:|  .:|.||||:    :...:|..:..|:|::.||.|.|.
Worm   425 RKRMPVGIVKCGQSASFAL---KKIPKKDVRKGMVLV----DPKVKPVASMVFEAEILVLHHPTT 482

  Fly   565 IYVGFQTTVHIGSIRQTAVIRGIMGGERLGTNDCASVMFEFVGHPEYVRPGMRILFREGTSKGIG 629
            |...:|..:||||:||||.:.. ||.|.|.|.|...|.|:|:..|||:|||.:::||||.:|.:|
Worm   483 IKPNYQAMLHIGSVRQTATLVS-MGKEVLRTGDRDKVQFKFIRQPEYIRPGTKMVFREGRTKAVG 546

  Fly   630 VVTQVFP 636
            .|:.|.|
Worm   547 TVSSVVP 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2017	NP_649603.3	GTPBP1	100..635	CDD:227583	195/524 (37%)
		GTPBP1_like	217..436	CDD:206728	96/221 (43%)
		GTPBP_II	450..536	CDD:293895	31/87 (36%)
		GTPBP_III	547..634	CDD:294007	38/86 (44%)
cgp-1	NP_503137.1	GTPBP1	44..552	CDD:227583	194/520 (37%)
		GTPBP1_like	142..364	CDD:206728	96/226 (42%)
		GTPBP_II	373..459	CDD:293895	32/92 (35%)
		GTPBP_III	465..551	CDD:294007	38/86 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62195
OrthoDB	1	1.010	-	-		D305827at33208
OrthoFinder	1	1.000	-	-		FOG0002013
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100969
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820