DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1213 and HXT1

DIOPT Version :9

Sequence 1:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_011962.1	Gene:	HXT1 / 856494	SGDID:	S000001136	Length:	570	Species:	Saccharomyces cerevisiae

Alignment Length:	536	Identity:	136/536 - (25%)
Similarity:	228/536 - (42%)	Gaps:	97/536 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 STFQIREGNTRTM-SPE--------------------PVKSGR-----IFMAAVAANLSAFVVGT 58
            :::::..|.::.| :||                    |..:|:     :.:..|......|:.|.
Yeast    17 NSYELESGRSKAMNTPEGKNESFHDNLSESQVQPAVAPPNTGKGVYVTVSICCVMVAFGGFIFGW 81

  Fly    59 TLGWTSPIGPK--------LKSEDTSDSPLSRPITSDEDAWISSLIAVGALVAPFVAGPMADRIG 115
            ..|..|....:        :|..|.|.. ||:..|    ..|.|:..:|..:...|...:.|..|
Yeast    82 DTGTISGFVAQTDFLRRFGMKHHDGSHY-LSKVRT----GLIVSIFNIGCAIGGIVLAKLGDMYG 141

  Fly   116 RKWVLLSSSLFFVLAFGLNMVASEVWILY-MSRLIQGFGVGFVMTVQPMYVGEISTDNVRGATGS 179
            |:..|:...:.:.:...:.:.:...|..| :.|:|.|.|||.:..:.||.:.|::...:||...|
Yeast   142 RRIGLIVVVVIYTIGIIIQIASINKWYQYFIGRIISGLGVGGITVLSPMLISEVAPSEMRGTLVS 206

  Fly   180 LMQLFIVGGILYVYA--IGPYVSYQALQWCCIVVPVVFDLVFYM------MPESPYFFAGKGRKS 236
            ..|:.|..||...|.  .|......::|| .:.:.:.|....:|      :||||.:....||..
Yeast   207 CYQVMITLGIFLGYCTNFGTKNYSNSVQW-RVPLGLCFAWALFMIGGMMFVPESPRYLVEAGRID 270

  Fly   237 EALKSLQFLRGQSAEG--VHDEMAEIQANVEEAMASKGTVM--DLF--KNAGNRRALFICAGLI- 294
            ||..||..:.....:.  :..|:..|:|:||| |.:.||..  :||  |.|..:|.:.   |::
Yeast   271 EARASLAKVNKCPPDHPYIQYELETIEASVEE-MRAAGTASWGELFTGKPAMFQRTMM---GIMI 331

  Fly   295 -SFQQLSGINVVLFNSQSIFASANTGLDPAIAT-IIIGCVQVGSSALTPLVADRLGRKVMLLTSS 357
             |.|||:|.|...:....:|.:  .||..:..| |:.|.|...|:..:....||.||:..|:..:
Yeast   332 QSLQQLTGDNYFFYYGTIVFQA--VGLSDSFETSIVFGVVNFFSTCCSLYTVDRFGRRNCLMWGA 394

  Fly   358 SVM--------SIGLAAL-----------GAFFYMQLVKGDISSVVWMPVPALIIYNIVYCTGFG 403
            ..|        |:|:..|           ||        |:...|.      ...|...:.|.:.
Yeast   395 VGMVCCYVVYASVGVTRLWPNGQDQPSSKGA--------GNCMIVF------ACFYIFCFATTWA 445

  Fly   404 PLPWAVLGEMFPANIKSVASSVVASTCWTLGFLVTFFYPSLDALGSYYAFWLFAVCMVVAFFFVL 468
            |:.:.|:.|.||..:||...|:.::..|..|||::||.|.:....::|..::|..|||.|:|:|.
Yeast   446 PIAYVVISECFPLRVKSKCMSIASAANWIWGFLISFFTPFITGAINFYYGYVFMGCMVFAYFYVF 510

  Fly   469 FVVMETKGLSLQQIQD 484
            |.|.|||||||:::.|
Yeast   511 FFVPETKGLSLEEVND 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1213	NP_001246937.1	SP	42..482	CDD:273317	129/484 (27%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	114/457 (25%)
HXT1	NP_011962.1	Sugar_tr	68..528	CDD:395036	130/485 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.710