DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1213 and ITR2

DIOPT Version :9

Sequence 1:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_014538.2	Gene:	ITR2 / 854050	SGDID:	S000005463	Length:	609	Species:	Saccharomyces cerevisiae

Alignment Length:	516	Identity:	131/516 - (25%)
Similarity:	232/516 - (44%)	Gaps:	74/516 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISREEETGVQYSYTEVSTFQIREGNTRTMSPEPVKSGRIFMAAVAANLSAFVVGTTLGWTSPIGP 68
            ::.|::|.|      :.||      .:::||      .|......|::|.|:.|...|:.|
Yeast    89 VNDEDDTSV------IITF------NQSISP------FIITLTFVASISGFMFGYDTGYIS---- 131

  Fly    69 KLKSEDTSDSPL--------SRPITSDEDAWISSLIAVGALVAPFVAGPMADRIGRKWVLLSSSL 125
                     |.|        ::.:|..|...|::..::|||:....||..||..||:..|:.|:|
Yeast   132 ---------SALISINRDLDNKVLTYGEKELITAATSLGALITSVGAGTAADVFGRRPCLMFSNL 187

  Fly   126 FFVLAFGLNMVASEVWILYMSRLIQGFGVGFVMTVQPMYVGEISTDNVRGATGSLMQLFIVGGIL 190
            .|::...|.:.|.:.|.:...|||.|||||....:.|:::.||:...:||....:..|::.||.|
Yeast   188 MFLIGAILQITAHKFWQMAAGRLIMGFGVGIGSLISPLFISEIAPKMIRGRLTVINSLWLTGGQL 252

  Fly   191 YVYAIGPYVSYQALQWCCIV----VPVVFDLVFY-MMPESPYFFAGKGRKSEALKSLQFLRGQSA 250
            ..|..|..:::....|..:|    :|.|....|: .:|::|.::..||....|...|:.....:.
Yeast   253 IAYGCGAGLNHVKNGWRILVGLSLIPTVLQFSFFCFLPDTPRYYVMKGDLKRAKMVLKRSYVNTE 317

  Fly   251 EGVHDEMAEIQANVEEAMASK-------GTVMDLFKNAGNRRALFICAGLISFQQLSGINVVLFN 308
            :.:.|:..|..:::.:::..|       ..|.:|.....|.|||.|..||.:.||.:|.|.:::.
Yeast   318 DEIIDQKVEELSSLNQSIPGKNPITKFWNMVKELHTVPSNFRALIIGCGLQAIQQFTGWNSLMYF 382

  Fly   309 SQSIFASANTGLDPAIATIIIGCVQVGSSALTPLVA----DRLGRKVMLLTSSSVMSIGLAALG- 368
            |.:||.:.......|::.|:     .|::.:..|:|    |::||:.:||.....|::.|....
Yeast   383 SGTIFETVGFKNSSAVSIIV-----SGTNFVFTLIAFFCIDKIGRRYILLIGLPGMTVALVICAI 442

  Fly   369 AFFYMQLVKGDISSVV-------W--MPVPALIIYNIVYCTGFGPLPWAVLGEMFPANIKSVASS 424
            ||.::.:......:||       |  :.:..:|:|...|..|.|.:||. ..|:||.|::.|.:|
Yeast   443 AFHFLGIKFNGADAVVASDGFSSWGIVIIVFIIVYAAFYALGIGTVPWQ-QSELFPQNVRGVGTS 506

  Fly   425 VVASTCWTLGFLV--TFFYPSLDALGSYYAFWLFAVCMVVAFFFVLFVVMETKGLSLQQIQ 483
            ...:|.|. |.||  :.|...|..:.....|..||....::..|..|...|..||.|:::|
Yeast   507 YATATNWA-GSLVIASTFLTMLQNITPTGTFSFFAGVACLSTIFCYFCYPELSGLELEEVQ 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1213	NP_001246937.1	SP	42..482	CDD:273317	123/475 (26%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	116/448 (26%)
ITR2	NP_014538.2	MFS_HMIT_like	115..556	CDD:340918	118/460 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9181
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810