DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1213 and AZR1

DIOPT Version :9

Sequence 1:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_011740.3	Gene:	AZR1 / 853139	SGDID:	S000003456	Length:	613	Species:	Saccharomyces cerevisiae

Alignment Length:	493	Identity:	88/493 - (17%)
Similarity:	171/493 - (34%)	Gaps:	130/493 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSISREEETGVQYSYTEVSTFQIREGNTRTMSPEPV---------------KSGRIFMAAVAAN 50
            |..:|...|...|.:..:...:.:|..:|::.|.:.|               |...::.:.:|..
Yeast    10 MSDLSYYGEKAQQQNEKQQKQYVVRRNSTQSTSKQNVSVVLEDNASESNELPKGFILYASLIALA 74

  Fly    51 LSAFVVGTTLGWTSPIGPKLKSEDTSDSPLSRPITSDEDAWISSLIAVGALVAPFVAGPMADRIG 115
            ||.|:....:...|.|..::..:..|.|         |..|:.:..::...:...:.|.:|..||
Yeast    75 LSLFLAALDIMIVSTIIEEVAKQFGSYS---------EIGWLFTGYSLPNALLALIWGRIATPIG 130

  Fly   116 RKWVLLSSSLFFVLAFGLNMVASEVWILYMSRLIQGFGVGFVMTVQPMYVGEISTDNVRGATGSL 180
            .|..:|.:.:.|.:...::.:|:.:.:|...|:|.|.|...:.::..:....:..::.||...::
Yeast   131 FKETMLFAIVIFEIGSLISALANSMSMLIGGRVIAGVGGCGIQSLSFVIGSTLVEESQRGILIAV 195

  Fly   181 MQL-FIVGGILYVYAIGPYVSYQALQWCCIVVPVVFDLVFYMMPESPYFFAGKGRKS--EALKSL 242
            :.. |.:..::..:..|.:.|....:||..|...:..|.|::.    .||...|..:  |.:.::
Yeast   196 LSCSFAIASVVGPFLGGVFTSSVTWRWCFYVNLPIGGLAFFLF----LFFYNPGLSTFQETMDNI 256

  Fly   243 QFLRGQSAEGVHD----------------------EMAEIQANVEEAMASKG--TVMDLFKNAGN 283
            :....|..|.|.:                      |:..:...:|....|.|  .::..|...||
Yeast   257 RKFPSQFIEIVRNVAYHLLKIKGFSKLNGWRKPFMELIFMYDIIEFVFCSAGFTCILLAFTFGGN 321

  Fly   284 RRA---------------LFICAGLISFQQLSGINVVLF--NSQSIFASANTGLDPAIATIIIGC 331
            |.|               |.:.||:..|......|:|..  :.|.:.:..|. ..|.|.|:.|
Yeast   322 RYAWNSASIIILFIIGIVLVVLAGIYDFLVFPKFNIVKATPHYQPLMSWTNI-KKPGIFTVNI-- 383

  Fly   332 VQVGSSALTPLVADRLGRKVMLLTSSSVMSIGLAALGAFFYM----QLVKGD------------- 379
                               .:.||.:..:|       .|.|:    ||:..|
Yeast   384 -------------------ALFLTCAGYIS-------QFTYIVQYFQLIYNDSAWRAAVHLVACI 422

  Fly   380 ISSVVWMPV------------PALIIYNIVYCTGFGPL 405
            ||:||...:            |.::|.:|....|.|.|
Yeast   423 ISTVVTAILCGAITDKTRQIKPIIVISSIFGVVGAGIL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1213	NP_001246937.1	SP	42..482	CDD:273317	79/437 (18%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	79/432 (18%)
AZR1	NP_011740.3	MFS_Azr1_MDR_like	83..540	CDD:341045	75/420 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900