DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1213 and HXT3

DIOPT Version :9

Sequence 1:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_010632.1	Gene:	HXT3 / 851946	SGDID:	S000002753	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	531	Identity:	144/531 - (27%)
Similarity:	236/531 - (44%)	Gaps:	75/531 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSISRE-----EETGVQYSYTEVSTFQIREGNTRTMSPEPVKSG--RIFMAAVAANLSAFVVGT 58
            :||.|.:     ||.|||      ..||.......| :|...|..  .:.:..|......||.|.
Yeast    21 LPSNSSQVMNMPEEKGVQ------DDFQAEADQVLT-NPNTGKGAYVTVSICCVMVAFGGFVFGW 78

  Fly    59 TLGWTSPIGPK--------LKSEDTSDSPLSRPITSDEDAWISSLIAVGALVAPFVAGPMADRIG 115
            ..|..|....:        :|.:|.| ..||:..|    ..|.|:..:|..:...:...:.|..|
Yeast    79 DTGTISGFVAQTDFLRRFGMKHKDGS-YYLSKVRT----GLIVSIFNIGCAIGGIILAKLGDMYG 138

  Fly   116 RKWVLLSSSLFFVLAFGLNMVASEVWILY-MSRLIQGFGVGFVMTVQPMYVGEISTDNVRGATGS 179
            ||..|:...:.:::...:.:.:...|..| :.|:|.|.|||.:..:.||.:.|::...:||...|
Yeast   139 RKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVAPKEMRGTLVS 203

  Fly   180 LMQLFIVGGILYVYA--IGPYVSYQALQWCCIVVPVVFDLVFYM------MPESPYFFAGKGRKS 236
            ..||.|..||...|.  .|......::|| .:.:.:.|....:|      :||||.:....|:..
Yeast   204 CYQLMITLGIFLGYCTNFGTKNYSNSVQW-RVPLGLCFAWALFMIGGMTFVPESPRYLVEAGQID 267

  Fly   237 EALKSLQFLRGQSAEG--VHDEMAEIQANVEEAMASKGTVM--DLF--KNAGNRRALFICAGLI- 294
            ||..||..:...:.:.  :..|:..|:|:||||.|: |:..  :||  |.|..:|.:.   |::
Yeast   268 EARASLSKVNKVAPDHPFIQQELEVIEASVEEARAA-GSASWGELFTGKPAMFKRTMM---GIMI 328

  Fly   295 -SFQQLSGINVVLFNSQSIFASANTGLDPAIAT-IIIGCVQVGSSALTPLVADRLGRKVMLLTSS 357
             |.|||:|.|...:...::|.:  .|:..:..| |:.|.|...|:..:....||.||:..||..
Yeast   329 QSLQQLTGDNYFFYYGTTVFNA--VGMSDSFETSIVFGVVNFFSTCCSLYTVDRFGRRNCLLYG- 390

  Fly   358 SVMSIGL-------AALGAFFYMQLVKGDISS-------VVWMPVPALIIYNIVYCTGFGPLPWA 408
               :||:       |::|........:|:.||       :|:     ...|...:.|.:.|:.:.
Yeast   391 ---AIGMVCCYVVYASVGVTRLWPNGEGNGSSKGAGNCMIVF-----ACFYIFCFATTWAPIAYV 447

  Fly   409 VLGEMFPANIKSVASSVVASTCWTLGFLVTFFYPSLDALGSYYAFWLFAVCMVVAFFFVLFVVME 473
            |:.|.||..:||.|.|:..:..|..|||:.||.|.:....::|..::|..|||.|:|:|.|.|.|
Yeast   448 VISETFPLRVKSKAMSIATAANWLWGFLIGFFTPFITGAINFYYGYVFMGCMVFAYFYVFFFVPE 512

  Fly   474 TKGLSLQQIQD 484
            ||||:|:::.|
Yeast   513 TKGLTLEEVND 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1213	NP_001246937.1	SP	42..482	CDD:273317	130/479 (27%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	116/452 (26%)
HXT3	NP_010632.1	Sugar_tr	65..525	CDD:395036	131/480 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.800