Protein Alignment CG1213 and SLC2A4

DIOPT Version :10

• Sequence 1: NP_649599.1
• Gene: CG1213 / 40728
• FlyBaseID: FBgn0037387
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_001033.1
• Gene: SLC2A4 / 6517
• HGNCID: 11009
• Length: 509
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 144/488 - (29%)
• Similarity: 226/488 - (46%)
• Gaps: 63/488 - (12%)

  Fly    34 PEPVKSGRIFMAAVAANLSAFVVGTTLG----------------WTSPIGPKLKSEDTSDSPLSR 82
            |:...:|.:.:|..:|.|.:...|..:|                |....||        :.|.|.
Human    16 PQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGP--------EGPSSI 72

  Fly    83 PITSDEDAWISS--LIAVGALVAPFVAGPMADRIGRKWVLLSSSLFFVLA---FGLNMVASEVWI 142
            |..:....|..|  :.:||.:::.|:.|.::..:|||..:|.:::..||.   .||...|:...:
Human    73 PPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEM 137

  Fly   143 LYMSRLIQGFGVGFVMTVQPMYVGEISTDNVRGATGSLMQLFIVGGILYVYAIG-PYVSYQALQW 206
            |.:.|.:.|...|....:.|||||||:..::|||.|:|.||.||.|||....:| ..:...|..|
Human   138 LILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLW 202

  Fly   207 CCI----VVPVVFDLVFY-MMPESP-YFFAGKGRKSEALKSLQFLRG-QSAEGVHDEMAEIQANV 264
            ..:    |:|.:..||.. ..|||| |.:..:..:..|.|||:.|.| ....||..|:.:.:..:
Human   203 PLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKL 267

  Fly   265 EEAMASKGTVMDLFKNAGNRRALFICAGLISFQQLSGINVVLFNSQSIFASANTGLDPAIATIII 329
            |.....  :::.|..:..:|:.|.|...|...|||||||.|.:.|.|||.:|..| .||.|||..
Human   268 ERERPL--SLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVG-QPAYATIGA 329

  Fly   330 GCVQVGSSALTPLVADRLGRKVMLLTSSSVMSIGLAAL-GAFFYMQLVKGDISSVVWMPVPALII 393
            |.|....:.::.|:.:|.||:.:.|       :|||.: |....|     .::.::...|||:..
Human   330 GVVNTVFTLVSVLLVERAGRRTLHL-------LGLAGMCGCAILM-----TVALLLLERVPAMSY 382

  Fly   394 YNIVYCTGF--------GPLPWAVLGEMFPANIKSVASSVVASTCWTLGFLVTF-FYPSLDALGS 449
            .:||...||        ||:||.::.|:|....:..|.:|...:.||..|::.. |....:|:|.
Human   383 VSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGP 447

  Fly   450 YYAFWLFAVCMVVAFFFVLFVVMETKGLSLQQI 482
             |.|.||||.::..|.|....|.||:|.:..||
Human   448 -YVFLLFAVLLLGFFIFTFLRVPETRGRTFDQI 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1213	NP_649599.1	MFS_GLUT6_8_Class3_like	43..481	CDD:340916	140/476 (29%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269|PubMed:16647043	7..13
		MFS_GLUT_Class1	26..474	CDD:340989	139/471 (30%)
		Dileucine internalization motif. /evidence=ECO:0000269|PubMed:8300557	489..490