DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1213 and SLC2A1

DIOPT Version :9

Sequence 1:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_006507.2	Gene:	SLC2A1 / 6513	HGNCID:	11005	Length:	492	Species:	Homo sapiens

Alignment Length:	486	Identity:	144/486 - (29%)
Similarity:	223/486 - (45%)	Gaps:	58/486 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MSPEPVK-SGRIFMAAVAANLSAFVVGTTLG----------------WTSPIGPKLKSEDTSDSP 79
            |.|...| :||:.:|...|.|.:...|...|                |....|         :|.
Human     1 MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYG---------ESI 56

  Fly    80 LSRPITSDEDAWISS--LIAVGALVAPFVAGPMADRIGRK-WVLLSSSLFFVLA--FGLNMVASE 139
            |...:|:   .|..|  :.:||.::..|..|...:|.||: .:|:.:.|.||.|  .|.:.:...
Human    57 LPTTLTT---LWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKS 118

  Fly   140 VWILYMSRLIQGFGVGFVMTVQPMYVGEISTDNVRGATGSLMQLFIVGGIL--YVYAIGPYVSYQ 202
            ..:|.:.|.|.|...|......||||||:|...:|||.|:|.||.||.|||  .|:.:...:..:
Human   119 FEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNK 183

  Fly   203 ALQW----CCIVVPVVFD-LVFYMMPESPYF-FAGKGRKSEALKSLQFLRGQSAEGVHDEMAEIQ 261
            .| |    ..|.:|.:.. :|....||||.| ...:..::.|...|:.||| :|:..|| :.|::
Human   184 DL-WPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRG-TADVTHD-LQEMK 245

  Fly   262 ANVEEAMASKG-TVMDLFKNAGNRRALFICAGLISFQQLSGINVVLFNSQSIFASANTGLDPAIA 325
            ....:.|..|. |:::||::...|:.:.|...|...|||||||.|.:.|.|||..|.. ..|..|
Human   246 EESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGV-QQPVYA 309

  Fly   326 TIIIGCVQVGSSALTPLVADRLGRKVMLLTSSSVMSIGLAAL-GAFFYMQLVKGDISSVVWMPVP 389
            ||..|.|....:.::..|.:|.||:.:.|       ||||.: |....|.:....:..:.||...
Human   310 TIGSGIVNTAFTVVSLFVVERAGRRTLHL-------IGLAGMAGCAILMTIALALLEQLPWMSYL 367

  Fly   390 ALI-IYNIV--YCTGFGPLPWAVLGEMFPANIKSVASSVVASTCWTLGFLVTFFYPSLDALGSYY 451
            ::: |:..|  :..|.||:||.::.|:|....:..|.:|...:.||..|:|...:..::.|...|
Human   368 SIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPY 432

  Fly   452 AFWLFAVCMVVAFFFVLFVVMETKGLSLQQI 482
            .|.:|.|.:|:.|.|..|.|.||||.:..:|
Human   433 VFIIFTVLLVLFFIFTYFKVPETKGRTFDEI 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1213	NP_001246937.1	SP	42..482	CDD:273317	138/473 (29%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	128/446 (29%)
SLC2A1	NP_006507.2	MFS_GLUT_Class1	14..458	CDD:340989	137/466 (29%)
		Monosaccharide binding. /evidence=ECO:0000269\|PubMed:24847886	282..288		5/5 (100%)
		Disordered. /evidence=ECO:0000305\|PubMed:30197081	468..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810