DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1213 and Slc2a12

DIOPT Version :9

Sequence 1:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_849265.2	Gene:	Slc2a12 / 353169	MGIID:	3052471	Length:	622	Species:	Mus musculus

Alignment Length:	538	Identity:	133/538 - (24%)
Similarity:	230/538 - (42%)	Gaps:	107/538 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FMAAVAANLSAFVVGTTLGWTSPIGPKLKSEDTSDSPLSRPITSDEDAWISSLIAVGALVAPFVA 107
            |:.:|.|.:|..:||..||..|  |..|:....      ..:|..|...:.|.:.:||.:|....
Mouse    45 FLTSVTAAISGLLVGYELGLIS--GALLQIRTL------LALTCHEQEMVVSSLLIGAFLASLTG 101

  Fly   108 GPMADRIGRKWVLLSSSLFFVLAFGLNMVASEVWILYMSRLIQGFGVGFVMTVQPMYVGEISTDN 172
            |.:.||.||:..::.||....|...:.:::....:|.|.|:..|..:........:|:.||:..:
Mouse   102 GVLIDRYGRRLAIILSSCLLGLGSLVLIMSLSYTLLIMGRVAIGVSISLSSIATCVYIAEIAPQH 166

  Fly   173 VRGATGSLMQLFIVGGILYVYAIGPY----VSYQALQWCCIVVP--VVFDLVFYMMPESPYFFAG 231
            .||...||.:|.||.|||:.| |..|    :|........:|:|  |:..:..|.:|.||.|...
Mouse   167 RRGLLVSLNELMIVTGILFAY-ISNYAFANISNGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVM 230

  Fly   232 KGRKSEALKSLQFLRGQSAEGVHDEMAEIQANVEEAMASKGTVMDLFKNAGNRRA-LFICAGLIS 295
            ||::..|.|.|:.||..|  ...:|:..|::::::..  :.:..|||::..|.|. :.|...|:.
Mouse   231 KGQEESAGKVLRKLRVIS--DTTEELTLIKSSLKDEY--QYSFWDLFRSKDNMRTRILIGLTLVF 291

  Fly   296 FQQLSGINVVLFNSQSIFASANTGLDPA--IATIIIGCVQVGSSALTPLVADRLGRKVMLLTSSS 358
            |.|.:|...:||.:.::..|.....:.|  :|:..:|.|:|.|:....|:.|.:|.|..|...||
Mouse   292 FVQTTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPATLLVDHIGSKTFLCIGSS 356

  Fly   359 VMSIGLAALG---------------------------AFF------------------------- 371
            |||..|..:|                           .|:
Mouse   357 VMSASLLTMGIVNLNINMNFTNICRSHSLLNQSLEEFVFYATGNLSISNSSLREHFKRITPYSKG 421

  Fly   372 -YMQL-----VKGDI---------------------SSVV-----WMPVPALIIYNIVYCTGFGP 404
             :|.:     .||::                     ::||     |:.:.:|::|...:..|.||
Mouse   422 SFMPMGNGMEPKGEMTFTSSLPNAGLSRTEHQGVTDTAVVPAAYKWLSLASLLVYVAAFSIGLGP 486

  Fly   405 LPWAVLGEMFPANIKSVASSVVASTCWTLGFLVTF-FYPSLDALGSYYAFWLFAVCMVVAFFFVL 468
            :||.||.|:||..|:..|.::.:|..|.:..|::. |....|.:|..:..:::.:..:.:..||:
Mouse   487 MPWLVLSEIFPGGIRGRAMALTSSMNWGVNLLISLTFLTVTDLIGLSWVCFIYTIMSLASLAFVV 551

  Fly   469 FVVMETKGLSLQQIQDRL 486
            ..:.||||.||:||...|
Mouse   552 LFIPETKGCSLEQISVEL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1213	NP_001246937.1	SP	42..482	CDD:273317	130/532 (24%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	121/506 (24%)
Slc2a12	NP_849265.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Sugar_tr	48..569	CDD:278511	131/533 (25%)
		MFS	49..>367	CDD:119392	93/330 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3740
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.860