DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1213 and Slc2a12

DIOPT Version :9

Sequence 1:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001100921.1	Gene:	Slc2a12 / 308028	RGDID:	1310175	Length:	621	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	133/540 - (24%)
Similarity:	232/540 - (42%)	Gaps:	110/540 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FMAAVAANLSAFVVGTTLGWTSPIGPKLKSEDTSDSPLSRPITSDEDAWISSLIAVGALVAPFVA 107
            |:.:|.|.:|..:||..||..|  |..|:....      ..:|..|...:.|.:.:||.:|....
  Rat    45 FLTSVTAAISGLLVGYELGLIS--GALLQIRTL------LALTCHEQEMVVSSLLIGAFLASLTG 101

  Fly   108 GPMADRIGRKWVLLSSSLFFVLAFGLNMVASEVWILYMSRLIQGFGVGFVMTVQPMYVGEISTDN 172
            |.:.||.||:..::.||....|...:.:::....:|...|:..|..:........:|:.||:..:
  Rat   102 GVLIDRYGRRLTIILSSCLLGLGSLVLILSLSYTLLITGRVAIGVSISLSSIATCVYIAEIAPQH 166

  Fly   173 VRGATGSLMQLFIVGGILYVYAIGPY----VSYQALQWCCIVVP--VVFDLVFYMMPESPYFFAG 231
            .||...||.:|.||.|||:.| |..|    :|........:|:|  |:..:..|.:|.||.|...
  Rat   167 RRGLLVSLNELMIVTGILFAY-ISNYAFANISNGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVM 230

  Fly   232 KGRKSEALKSLQFLR--GQSAEGVHDEMAEIQANVEEAMASKGTVMDLFKNAGNRRA-LFICAGL 293
            ||::..|.|.|:.||  ..:||    |:..|::::::..  :.:..|||::..|.|. :.|...|
  Rat   231 KGQEEAAGKVLRKLRVISDTAE----ELTLIKSSLKDEY--QYSFWDLFRSKDNMRTRILIGLTL 289

  Fly   294 ISFQQLSGINVVLFNSQSIFASANTGLDPA--IATIIIGCVQVGSSALTPLVADRLGRKVMLLTS 356
            :.|.|.:|...:||.:.::..|.....:.|  :|:..:|.|:|.|:....|:.|.:|.|..|...
  Rat   290 VFFVQTTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPATLLVDHVGSKTFLCIG 354

  Fly   357 SSVMSIGLAALG---------------------------AFF--------------YMQLV---- 376
            ||||:..|..:|                           .|:              :::.|
  Rat   355 SSVMAASLLTMGIVNLNINMNFTNICRSHSPLNQSLEELVFYATGNLSVSNSSLGEHLKRVTPYS 419

  Fly   377 -------------KGDIS--------------------SVV-----WMPVPALIIYNIVYCTGFG 403
                         ||:::                    :||     |:.:.:|::|...:..|.|
  Rat   420 KGLFIPLGNGMEPKGEMAFTSLPNAGLSRTDRQGVTDPAVVPAVYKWLSLASLLVYVAAFSIGLG 484

  Fly   404 PLPWAVLGEMFPANIKSVASSVVASTCWTLGFLVTF-FYPSLDALGSYYAFWLFAVCMVVAFFFV 467
            |:||.||.|:||..|:..|.::.:|..|.:..|::. |....|.:|..:..:::.|..:.:..||
  Rat   485 PMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLSWVCFIYTVMSLTSLAFV 549

  Fly   468 LFVVMETKGLSLQQIQDRLN 487
            :..:.||||.||:||...|:
  Rat   550 VLFIPETKGCSLEQISMELS 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1213	NP_001246937.1	SP	42..482	CDD:273317	130/533 (24%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	121/507 (24%)
Slc2a12	NP_001100921.1	MFS_GLUT12_Class3	46..564	CDD:340993	129/532 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820