DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1213 and SLC2A6

DIOPT Version :9

Sequence 1:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_060055.2	Gene:	SLC2A6 / 11182	HGNCID:	11011	Length:	507	Species:	Homo sapiens

Alignment Length:	499	Identity:	147/499 - (29%)
Similarity:	229/499 - (45%)	Gaps:	57/499 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PEP--------VKSGRIFMAAVAANLSAFVVGTTLGWTSPIGPKLKSEDTSDSPLSRPITSDEDA 90
            |.|        :::.|:|:|..||.|..|..|..|.:|||:.|.|  |.:.|..|.  :|..:.:
Human    22 PSPGDRARVGTLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPAL--ERSLDPDLH--LTKSQAS 82

  Fly    91 WISSLIAVGALVAPFVAGPMADRIGRKWVLLSSSLFFVLAFGLNMVASEVWILYMSRLIQGFGVG 155
            |..|:..:||......|..:.|.:|||..::.|::.....:.|...|..:|:|.:.|.:.||..|
Human    83 WFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGG 147

  Fly   156 FVMTVQPMYVGEISTDNVRGATGSLMQLFIVGGILYVYAIGPYVSYQALQWCCIV--VPV-VFDL 217
            ......|:||.||:...||||.|:..||..|.|.|.:||:|..:.:   :|..:.  .|| :..|
Human   148 LTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALGLLLPW---RWLAVAGEAPVLIMIL 209

  Fly   218 VFYMMPESPYFFAGKGRKSEALKSLQFLRGQSAEGVHDEMAEIQANVEEAMASKGTVMDLFKNAG 282
            :...||.||.|...:||..|||::|.:|||...: ||.|..:||.||....:.        .:..
Human   210 LLSFMPNSPRFLLSRGRDEEALRALAWLRGTDVD-VHWEFEQIQDNVRRQSSR--------VSWA 265

  Fly   283 NRRALFICAGLI------SFQQLSGINVVLFNSQSIFASANTGLDPAIATIIIGCVQVGSSALTP 341
            ..||..:|..:.      ..|||:||..:|...||||.|....|.|.....|:|.|::.|..:..
Human   266 EARAPHVCRPITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAA 330

  Fly   342 LVADRLGRKVMLLTSSSVMSIGLAALGAFFYM----------------------QLVKGDISSVV 384
            |..|..||||:|..|:::|......||.:.:.                      |.:......:.
Human   331 LTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLT 395

  Fly   385 WMPVPALIIYNIVYCTGFGPLPWAVLGEMFPANIKSVASSVVASTCWTLGFLVT-FFYPSLDALG 448
            .:|:.|.:::.:.|..|:||:.|.::.|:.|...:.|||.:.....|...|::| .|.|.:...|
Human   396 LVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFG 460

  Fly   449 SYYAFWLFAVCMVVAFFFVLFVVMETKGLSLQQIQDRL-NGKRN 491
            ....|:.||...:|:..|....|.||||.||:||:... .|:|:
Human   461 LQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIESFFRTGRRS 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1213	NP_001246937.1	SP	42..482	CDD:273317	140/471 (30%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	129/444 (29%)
SLC2A6	NP_060055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		2/5 (40%)
		Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS_GLUT6_Class3	39..493	CDD:340992	140/469 (30%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	286..292		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820