DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1208 and HXT14

DIOPT Version :9

Sequence 1:	NP_001097692.1	Gene:	CG1208 / 40727	FlyBaseID:	FBgn0037386	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_014081.1	Gene:	HXT14 / 855398	SGDID:	S000005262	Length:	540	Species:	Saccharomyces cerevisiae

Alignment Length:	537	Identity:	127/537 - (23%)
Similarity:	227/537 - (42%)	Gaps:	93/537 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TVSQEDGDSRNPITYDLLQENQSKTSKTRQYVAAMIICLGAVAAGTALSWTSPVFPQISAGNESS 80
            |:...|....|      ::...:|.|........:::||.....|....|..
Yeast    33 TIKYLDDKEEN------IEGQAAKISHNASLHIPVLLCLVISLGGFIFGWDI------------- 78

  Fly    81 FNSTTGGISNSTSNENDI-----------------RLTDSQKTLVGSMLPFGALFGALPSGYIAD 128
              .|.||::|..|.:...                 :|||.|..|:.|:.......|||....|.|
Yeast    79 --GTIGGMTNMVSFQEKFGTTNIIHDDETIFVSTKKLTDLQIGLIISIFNISCGVGALTLSKIGD 141

  Fly   129 RIGRR---YTAMVMDIPFILAWITLSFANSVGW--LYLGRFLIGIATGSFCVVAPMYISEIAETS 188
            .|||:   :.|:|:    ....||:...:...|  |.|||.:.||..|...|:.||::||.:...
Yeast   142 WIGRKGGIWFALVV----YCIGITIQILSYGRWYFLTLGRAVTGIGVGVTTVLVPMFLSENSPLK 202

  Fly   189 IRGSLGTLFQLLLTIGILFIYVVGAL-----------VSWKTLSLLCLIIPILLLVGLFIVPETP 242
            ||||:.:.:||::|.|||...::..:           ::|:....|..|..|::.:.|..|||:|
Yeast   203 IRGSMVSTYQLIVTFGILMGNILNFICERCYKDPTQNIAWQLPLFLGYIWAIIIGMSLVYVPESP 267

  Fly   243 VYL--LKNGKRSEANRALKWLWGDYCNTSNAIQAIQNDL------DQTGVDASVKDLFSNRASRN 299
            .||  :||...| |..:...:.|.....|..|:.|.:.|      ::|..::..:.|    ..||
Yeast   268 QYLAKIKNDVPS-AKYSFARMNGIPATDSMVIEFIDDLLENNYNNEETNNESKKQSL----VKRN 327

  Fly   300 -------------GMVISVLLMVFQQFSGINAVIFFMNEIFESSSTLNPNVCTIVVGVVQVIMTL 351
                         .::|.:::|.|||.||||...::...:|:.....:|.:.:|::..|..:.|:
Yeast   328 TFEFIMGKPKLWLRLIIGMMIMAFQQLSGINYFFYYGTSVFKGVGIKDPYITSIILSSVNFLSTI 392

  Fly   352 ASSLLIEKAGRKILLIFSSTIMTVCLAMLGAYNTINRHTDLSQSIGWLPLLCIVLFIVSFSVGYG 416
            .....:||.|.|..|::.||.:...:.......|..|.||.|..:..:...|   ||..|::..|
Yeast   393 LGIYYVEKWGHKTCLLYGSTNLLFYMMTYATVGTFGRETDFSNIVLIIVTCC---FIFWFAITLG 454

  Fly   417 PIPWMMMGELFMPDVKGIAVSLSVMMNWVCVSLVTWLFGVLNAGGADVPF---WFFSAWMGVATA 478
            |:.::::.|||....:.|::::...:||:...|::.|..::   .:.:.|   :.|:|.:.....
Yeast   455 PVTFVLVSELFPLRTRAISMAICTFINWMFNFLISLLTPMI---VSKIDFKLGYIFAACLLALII 516

  Fly   479 YVAIALQETKGKSASQI 495
            :..|.:.||:.|:..:|
Yeast   517 FSWILVPETRKKNEQEI 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1208	NP_001097692.1	MFS	96..482	CDD:119392	108/442 (24%)
CG1208	NP_001097692.1	MFS_1	96..443	CDD:284993	101/400 (25%)
HXT14	NP_014081.1	MFS_HXT	62..537	CDD:340914	122/502 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710