DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1208 and VPS73

DIOPT Version :9

Sequence 1:	NP_001097692.1	Gene:	CG1208 / 40727	FlyBaseID:	FBgn0037386	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_011411.3	Gene:	VPS73 / 852774	SGDID:	S000003072	Length:	486	Species:	Saccharomyces cerevisiae

Alignment Length:	493	Identity:	122/493 - (24%)
Similarity:	230/493 - (46%)	Gaps:	65/493 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QENQSKTSKTRQYVAAMIICLGAVAAGTALSWTSPVFPQISAGNE----SSFNSTTGGIS----- 89
            ::|:.|.:|...| |.::..:|::..|..||       :::|..:    |.|:....|..
Yeast    18 RQNKHKITKALCY-AIIVASIGSIQFGYHLS-------ELNAPQQVLSCSEFDIPMEGYPYDRTW 74

  Fly    90 -NSTSNENDIRLTDSQKTLVGSMLPFGALFGALPSGYIADRIGRRYTAMVMDIPFILAWITLSFA 153
             .....:..|.|.|.|..:|.|:...|.:.|:..:..:|:..||::::::.....|:..:.:..:
Yeast    75 LGKRGYKQCIPLNDEQIGIVTSVFCIGGILGSYFATSLANIYGRKFSSLINCTLNIVGSLIIFNS 139

  Fly   154 NSVGWLYLGRFLIGIATGSFCVVAPMYISEIAETSIRGSLGTLFQLLLTIGILFIYVVGALVS-- 216
            ||...|.:||.|:||:.||..|:.|::|.|:|.:...|.||::.|:.:.:|:|....:...::
Yeast   140 NSYRGLIIGRILVGISCGSLIVIIPLFIKEVAPSGWEGLLGSMTQICIRLGVLLTQGIALPLTDS 204

  Fly   217 --WKTLSLLCLIIPILLLVGLFIVPETPVYLLKNGKRSEANRALKWLWGDYCNTSNAIQAIQN-D 278
              |:.:.....:|.:|.....|||.|:|.:||.:|:.::|..:|..|.|  .....|.|.||: .
Yeast   205 YRWRWILFGSFLIAVLNFFMWFIVDESPKWLLAHGRVTDAKLSLCKLRG--VTFDEAAQEIQDWQ 267

  Fly   279 LDQTGVDASVKDLFSNRAS---------------RNGMVISVLLMVFQQFSGINAVIFFMNEIFE 328
            |.....|..::...:|..|               ::..||:|||. .|||.|||:::.:..:|.
Yeast   268 LQIESGDPLIEPTTTNSISGSNSLWKYLRDRTNVKSRHVITVLLF-GQQFCGINSIVLYGTKII- 330

  Fly   329 SSSTLNPNVC---TIVVGVVQVIMTLASSLLIEKAGRKILLIFSSTIMTVCLAMLGA---YNTIN 387
              |.|.|...   ...:.:|.|::|:..||||....||.||:.|:.:::|...::|.   :|.:|
Yeast   331 --SQLYPQHAIRINFFISMVNVLVTILVSLLIHSLPRKPLLMTSTVLVSVTAFIMGIAMNHNKMN 393

  Fly   388 RHTDLSQSIGWLPLLCIVLFIVS--FSVGYGPIPWMMMGELFMPDVKGIAVSLSVMMNWVCVSLV 450
                         ||.:..||..  |::|..|:|:::|.|:..|....:|.....:.|||...::
Yeast   394 -------------LLIVFSFIYMGVFTMGLNPLPFIIMREVSKPQDMVLAQRYGTICNWVGTFII 445

  Fly   451 TWLFGVLNAGGADVPFWFFSAWMGVATAYVAIALQETK 488
            .:.|.:::...:...|..|:......:|::...:.|||
Yeast   446 AYTFPIIHDVLSGYVFIIFAIIACSISAFIWKKVPETK 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1208	NP_001097692.1	MFS	96..482	CDD:119392	106/413 (26%)
CG1208	NP_001097692.1	MFS_1	96..443	CDD:284993	99/374 (26%)
VPS73	NP_011411.3	MFS_GLUT_Class1_2_like	31..484	CDD:340915	118/479 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	174	1.000	Inparanoid score	I987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860