DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1208 and ITR1

DIOPT Version :9

Sequence 1:	NP_001097692.1	Gene:	CG1208 / 40727	FlyBaseID:	FBgn0037386	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_010785.1	Gene:	ITR1 / 852108	SGDID:	S000002905	Length:	584	Species:	Saccharomyces cerevisiae

Alignment Length:	541	Identity:	142/541 - (26%)
Similarity:	242/541 - (44%)	Gaps:	80/541 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSEKVVRAMAR------WWQTVSQEDGDSRNPITYDLLQENQSKTSKTRQYVAAMIICLGAVAA 59
            ::|.::.||.|.      ..:.|:.|| |:...||:     |||        ::..||.|..||:
Yeast    44 LESHEIQRAPASDDEDRIQIKPVNDED-DTSVMITF-----NQS--------LSPFIITLTFVAS 94

  Fly    60 GTALSWTSPVFPQISAGNESSFNSTTGGISN---STSNENDIR-LTDSQKTLVGSMLPFGALFGA 120
            .:..                .|...||.||:   |...:.|.: ||..:|.:|.:....|||..:
Yeast    95 ISGF----------------MFGYDTGYISSALISIGTDLDHKVLTYGEKEIVTAATSLGALITS 143

  Fly   121 LPSGYIADRIGRRYTAMVMDIPFILAWITLSFANSVGWLYLGRFLIGIATGSFCVVAPMYISEIA 185
            :.:|..||..||:...|..::.|::..|....|::...:.:||.::|...|...::||::|||||
Yeast   144 IFAGTAADIFGRKRCLMGSNLMFVIGAILQVSAHTFWQMAVGRLIMGFGVGIGSLIAPLFISEIA 208

  Fly   186 ETSIRGSLGTLFQLLLTIGILFIYVVGALVS-----WKTLSLLCLIIPILLLVGLFIVPETPVYL 245
            ...|||.|..:..|.||.|.|..|..||.::     |:.|..|.||...:....|..:|:||.|.
Yeast   209 PKMIRGRLTVINSLWLTGGQLVAYGCGAGLNYVNNGWRILVGLSLIPTAVQFTCLCFLPDTPRYY 273

  Fly   246 LKNGKRSEANRALKWLWGDYCNTSNAI------------QAIQNDLDQTGVDASVKDLFSNRASR 298
            :..|..:.|...||   ..|.:||..|            |:|........|..::|:|.:..::.
Yeast   274 VMKGDLARATEVLK---RSYTDTSEEIIERKVEELVTLNQSIPGKNVPEKVWNTIKELHTVPSNL 335

  Fly   299 NGMVISVLLMVFQQFSGINAVIFFMNEIFESSSTLNPNVCTIVVGVVQVIMTLASSLLIEKAGRK 363
            ..::|...|...|||:|.|::::|...|||:....|.:..:|:|.....|.||.:...|:|.||:
Yeast   336 RALIIGCGLQAIQQFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFIFTLVAFFSIDKIGRR 400

  Fly   364 ILLIFSSTIMTVCLAMLG-AYNTINRHTDLSQSI---------GWLPLLCIVLFIVSFSVGYGPI 418
            .:|:.....||:.|.:.. |::.:....|.:.::         |.:.::.|::|...:::|.|.:
Yeast   401 TILLIGLPGMTMALVVCSIAFHFLGIKFDGAVAVVVSSGFSSWGIVIIVFIIVFAAFYALGIGTV 465

  Fly   419 PWMMMGELFMPDVKGIAVSLSVMMNW-----VCVSLVTWLFGVLNAGGADVPFWFFSAWMGVATA 478
            || ...|||..:|:||..|.:...||     :..:.:|.|..:..||    .|.||:....::|.
Yeast   466 PW-QQSELFPQNVRGIGTSYATATNWAGSLVIASTFLTMLQNITPAG----TFAFFAGLSCLSTI 525

  Fly   479 YVAIALQETKGKSASQIQSWL 499
            :......|..|....::|:.|
Yeast   526 FCYFCYPELSGLELEEVQTIL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1208	NP_001097692.1	MFS	96..482	CDD:119392	114/418 (27%)
CG1208	NP_001097692.1	MFS_1	96..443	CDD:284993	104/374 (28%)
ITR1	NP_010785.1	MFS_HMIT_like	92..533	CDD:340918	122/464 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2521
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13428
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X729
TreeFam	0	0.000	Not matched by this tool.
	5	4.760