DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1208 and HXT6

DIOPT Version :9

Sequence 1:	NP_001097692.1	Gene:	CG1208 / 40727	FlyBaseID:	FBgn0037386	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_010630.1	Gene:	HXT6 / 851944	SGDID:	S000002751	Length:	570	Species:	Saccharomyces cerevisiae

Alignment Length:	520	Identity:	117/520 - (22%)
Similarity:	223/520 - (42%)	Gaps:	71/520 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DGDSRNPITYDLLQENQSKTSKTRQYVAAMIICLGAVAAGTALSWTSPVFPQISAGNESSFNSTT 85
            :|:...|:.       :........||...|:|:.....|....|        ..|..|.|.:.|
Yeast    44 EGEEHEPVV-------EIPKRPASAYVTVSIMCIMIAFGGFVFGW--------DTGTISGFINQT 93

  Fly    86 GGISNSTSNEND--IRLTDSQKTLVGSMLPFGALFGALPSGYIADRIGRRYTAMVMDIPFILAWI 148
            ..|........|  ..|:..:..|:.|:...|...|.:....:.|..||:...:|:.:.:|:. |
Yeast    94 DFIRRFGMKHKDGTNYLSKVRTGLIVSIFNIGCAIGGIILSKLGDMYGRKVGLIVVVVIYIIG-I 157

  Fly   149 TLSFANSVGW--LYLGRFLIGIATGSFCVVAPMYISEIAETSIRGSLGTLFQLLLTIGILFIYVV 211
            .:..|:...|  .::||.:.|:..|...|::||.|||::...:||:|.:.:||::|.||...|..
Yeast   158 IIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHLRGTLVSCYQLMITAGIFLGYCT 222

  Fly   212 -------GALVSWKTLSLLCLIIPILLLVGLFIVPETPVYLLKNGKRSEANRALKWLWGDYCNTS 269
                   ...|.|:....||....:.::.|:..|||:|.||.:.||..||.|::.        .|
Yeast   223 NFGTKNYSNSVQWRVPLGLCFAWALFMIGGMTFVPESPRYLAEVGKIEEAKRSIA--------VS 279

  Fly   270 NAIQAIQN--------------DLDQTGVDASVKDLFSNRAS-RNGMVISVLLMVFQQFSGINAV 319
            |.: |:.:              :.::...:||..:|||::.. ...:::..::...||.:|.|..
Yeast   280 NKV-AVDDPSVLAEVEAVLAGVEAEKLAGNASWGELFSSKTKVLQRLIMGAMIQSLQQLTGDNYF 343

  Fly   320 IFFMNEIFESSSTLNPNVCTIVVGVVQVIMTLASSLLIEKAGRKILLIFSSTIMTVCLAMLGAYN 384
            .::...||::....:....:||:|:|....|.....::|:.||:..|::.:..||.|:.:..:..
Yeast   344 FYYGTTIFKAVGLSDSFETSIVLGIVNFASTFVGIYVVERYGRRTCLLWGAASMTACMVVYASVG 408

  Fly   385 TI-----NRHTDLSQSIGWLPLLCIVLFIVSFSVGYGPIPWMMMGELFMPDVKGIAVSLSVMMNW 444
            ..     .:....|:..|...::....:|..|:..:.|||::::.|.|...||..|:|::...||
Yeast   409 VTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFATTWAPIPYVVVSETFPLRVKSKAMSIATAANW 473

  Fly   445 VCVSLV----TWLFGVLNAGGADVPFWFFSAWMGVAT---AYVAIALQETKGKSASQIQS-WLSG 501
            :...|:    .::.|.:|       |::...:||...   .||.:.:.||||.:..::.: |..|
Yeast   474 LWGFLIGFFTPFITGAIN-------FYYGYVFMGCLVFMFFYVLLVVPETKGLTLEEVNTMWEEG 531

Fly 502 501
Yeast 532 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1208	NP_001097692.1	MFS	96..482	CDD:119392	98/423 (23%)
CG1208	NP_001097692.1	MFS_1	96..443	CDD:284993	88/377 (23%)
HXT6	NP_010630.1	Sugar_tr	68..528	CDD:278511	110/484 (23%)
HXT6	NP_010630.1	MFS	69..514	CDD:119392	106/469 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342852
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.640