DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1208 and SLC2A3

DIOPT Version :9

Sequence 1:	NP_001097692.1	Gene:	CG1208 / 40727	FlyBaseID:	FBgn0037386	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_008862.1	Gene:	SLC2A3 / 6515	HGNCID:	11007	Length:	496	Species:	Homo sapiens

Alignment Length:	499	Identity:	143/499 - (28%)
Similarity:	232/499 - (46%)	Gaps:	72/499 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 TRQYVAAMIICLGAVAAGTALSWTSPVFPQISAGNESSFNSTTGGIS----------NSTSNE-- 95
            |::...|:|..:.....|:                 ..|...||.|:          |.|..:
Human     3 TQKVTPALIFAITVATIGS-----------------FQFGYNTGVINAPEKIIKEFINKTLTDKG 50

  Fly    96 ----NDIRLTDSQKTLVGSMLPFGALFGALPSGYIADRIGRRYTAMVMDIPFILAWITLSF---A 153
                :::.|| |..:|..::...|.:.|:...|...:|.|||.:.:::::..:.....:..   |
Human    51 NAPPSEVLLT-SLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVA 114

  Fly   154 NSVGWLYLGRFLIGIATGSFCVVAPMYISEIAETSIRGSLGTLFQLLLTIGILFI------YVVG 212
            .||..|.|||.:||:..|......||||.||:.|::||:.|||.||.:.:|||..      :::|
Human   115 KSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILG 179

  Fly   213 ALVSWKTLSLLCLIIPILLLVGLFIVPETPVYLLKNGKRSE-ANRALKWLWGDYCNTSNAIQAIQ 276
            :...|..|....::..||....|...||:|.:||.|.|..| |.:.|:.|||    |.:..|.||
Human   180 SEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWG----TQDVSQDIQ 240

  Fly   277 NDLDQTG-----VDASVKDLFSNRASRNGMVISVLLMVFQQFSGINAVIFFMNEIFESSSTLNPN 336
            ...|::.     ...:|.:||...:.|..::||::|.:.||.||||||.::...||:.:....|.
Human   241 EMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPI 305

  Fly   337 VCTIVVGVVQVIMTLASSLLIEKAGRKIL-------LIFSSTIMTVCLAMLGAYNTINRHTDLSQ 394
            ..||..|||..|.|:.|..|:|:|||:.|       :.|.||:|||.|.:...||
Human   306 YATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYN---------- 360

  Fly   395 SIGWLPLLCIVLFIVSFSVGYGPIPWMMMGELFMPDVKGIAVSLSVMMNWVCVSLVTWLF-GVLN 458
            .:.::.:..|::|:..|.:|.|||||.::.|||....:..|::::...||....||..|| ...:
Human   361 GMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAH 425

  Fly   459 AGGADVPFWFFSAWMGVATAYVAIALQETKGKSASQIQSWLSGR 502
            ..||.| |..|:.::....|:....:.||:|::...|.....|:
Human   426 YLGAYV-FIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQ 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1208	NP_001097692.1	MFS	96..482	CDD:119392	128/408 (31%)
CG1208	NP_001097692.1	MFS_1	96..443	CDD:284993	116/368 (32%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	137/476 (29%)
		Important for selectivity against fructose. /evidence=ECO:0000269\|PubMed:26176916	277..279		0/1 (0%)
		Monosaccharide binding. /evidence=ECO:0000269\|PubMed:26176916	280..286		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740