DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1208 and Slc2a4

DIOPT Version :9

Sequence 1:	NP_001097692.1	Gene:	CG1208 / 40727	FlyBaseID:	FBgn0037386	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_036883.1	Gene:	Slc2a4 / 25139	RGDID:	2711	Length:	509	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	149/527 - (28%)
Similarity:	247/527 - (46%)	Gaps:	85/527 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MARWWQTVSQEDGD-SRNPITYDLLQENQSKTSKTRQYVAAMIICLGAVAAGTALSWTSPVFPQI 73
            |...:|.:..|||: .:..:|..|:             :|.....||::..|..:.       .|
  Rat     1 MPSGFQQIGSEDGEPPQQRVTGTLV-------------LAVFSAVLGSLQFGYNIG-------VI 45

  Fly    74 SAGN---ESSFNST------TGGISNSTSNENDIRLTDS--QKTLVG------SMLPFGALFGAL 121
            :|..   |.|:|:|      .||             .||  |.||..      ::...|.:..:.
  Rat    46 NAPQKVIEQSYNATWLGRQGPGG-------------PDSIPQGTLTTLWALSVAIFSVGGMISSF 97

  Fly   122 PSGYIADRIGRRYTAMVMDIPFILAWITLSFAN---SVGWLYLGRFLIGIATGSFCVVAPMYISE 183
            ..|.|:..:||:...:..::..:|....:..||   |...|.|||||||..:|....:.|||:.|
  Rat    98 LIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGE 162

  Fly   184 IAETSIRGSLGTLFQLLLTIGILFIYV------VGALVSWKTLSLLCLIIPILLLVGLFIVPETP 242
            ||.|.:||:||||.||.:.||||...|      :|....|..|..:.::..:|.|:.|...||:|
  Rat   163 IAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLAITVLPALLQLLLLPFCPESP 227

  Fly   243 --VYLLKNGKRSEANRALKWLWGDYCNTSNAIQAIQNDLDQTGVD--ASVKDLFSNRASRNGMVI 303
              :|:::| ....|.::||.|.| :.:.|:|:..::::..:...:  .|:..|..:|..|..::|
  Rat   228 RYLYIIRN-LEGPARKSLKRLTG-WADVSDALAELKDEKRKLERERPLSLLQLLGSRTHRQPLII 290

  Fly   304 SVLLMVFQQFSGINAVIFFMNEIFESSSTLNPNVCTIVVGVVQVIMTLASSLLIEKAGRKILLIF 368
            :|:|.:.||.||||||.::...|||.:....|...||..|||..:.||.|.||:|:|||:.|.:.
  Rat   291 AVVLQLSQQLSGINAVFYYSTSIFELAGVEQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLL 355

  Fly   369 S-------STIMTVCLAMLGAYNTINRHTDLSQSIGWLPLLCIVLFIVSFSVGYGPIPWMMMGEL 426
            .       :.:|||.|.:|          :...|:.::.::.|..|:..|.:|.|||||.::.||
  Rat   356 GLAGMCGCAILMTVALLLL----------ERVPSMSYVSIVAIFGFVAFFEIGPGPIPWFIVAEL 410

  Fly   427 FMPDVKGIAVSLSVMMNWVCVSLVTWLFG-VLNAGGADVPFWFFSAWMGVATAYVAIALQETKGK 490
            |....:..|::::...||.|..:|...|. |.:|.|..| |..|:..:.....:..:.:.||:|:
  Rat   411 FSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYV-FLLFAVLLLGFFIFTFLRVPETRGR 474

  Fly   491 SASQIQS 497
            :..||.:
  Rat   475 TFDQISA 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1208	NP_001097692.1	MFS	96..482	CDD:119392	125/414 (30%)
CG1208	NP_001097692.1	MFS_1	96..443	CDD:284993	114/374 (30%)
Slc2a4	NP_036883.1	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13		1/5 (20%)
		Sugar_tr	27..483	CDD:278511	142/488 (29%)
		MFS	78..447	CDD:119392	116/380 (31%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		4/5 (80%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337959
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740