DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1208 and Slc2a1

DIOPT Version :9

Sequence 1:	NP_001097692.1	Gene:	CG1208 / 40727	FlyBaseID:	FBgn0037386	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_620182.1	Gene:	Slc2a1 / 24778	RGDID:	3704	Length:	492	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	145/490 - (29%)
Similarity:	236/490 - (48%)	Gaps:	79/490 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MIICLGAVAAGTALSWTSPVF--PQ--ISAGNESSFNSTTGGISNSTSNENDIRLTDSQKTLVGS 110
            |:...|||.......:.:.|.  ||  |......::|...|....||:      || :..:|..:
  Rat    13 MLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTT------LT-TLWSLSVA 70

  Fly   111 MLPFGALFGALPSGYIADRIGRRYTAMVMDIPFILAWITLSFA---NSVGWLYLGRFLIGIATGS 172
            :...|.:.|:...|...:|.|||.:.::|::...::.:.:.|:   .|...|.||||:||:..|.
  Rat    71 IFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGL 135

  Fly   173 FCVVAPMYISEIAETSIRGSLGTLFQLLLTIGILFIYVVG--ALVS----WKTLSLLCLIIPILL 231
            .....|||:.|::.|::||:||||.||.:.:|||...|.|  :::.    |..| |..:.||.||
  Rat   136 TTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLL-LSVIFIPALL 199

  Fly   232 -LVGLFIVPETPVYLLKNGKRSEANRA---LKWLWGDYCNTSNAIQAIQNDLDQTG------VDA 286
             .:.|...||:|.:||.|  |:|.|||   ||.|.|    |::..:.:| ::.:.|      ...
  Rat   200 QCILLPFCPESPRFLLIN--RNEENRAKSVLKKLRG----TADVTRDLQ-EMKEEGRQMMREKKV 257

  Fly   287 SVKDLFSNRASRNGMVISVLLMVFQQFSGINAVIFFMNEIFESSSTLNPNVCTIVVGVVQVIMTL 351
            ::.:||.:.|.|..::|:|:|.:.||.||||||.::...|||.:....|...||..|:|....|:
  Rat   258 TILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTV 322

  Fly   352 ASSLLIEKAGRKILLIFS-------STIMTVCLAMLGAYNTINRHTDLSQSIGWLPLLCIVL--- 406
            .|..::|:|||:.|.:..       :.:||:.||:|             :.:.|:..|.||.
  Rat   323 VSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALL-------------EQLPWMSYLSIVAIFG 374

  Fly   407 FIVSFSVGYGPIPWMMMGELFMPDVKGIAVSLSVMMNW-------VCVSLVTWLFGVLNAGGADV 464
            |:..|.||.|||||.::.|||....:..||:::...||       :|...|..|.|
  Rat   375 FVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCG--------- 430

  Fly   465 PFWF--FSAWMGVATAYVAIALQETKGKSASQIQS 497
            |:.|  |:..:.:...:....:.||||::..:|.|
  Rat   431 PYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIAS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1208	NP_001097692.1	MFS	96..482	CDD:119392	127/423 (30%)
CG1208	NP_001097692.1	MFS_1	96..443	CDD:284993	118/375 (31%)
Slc2a1	NP_620182.1	MFS_GLUT_Class1	14..458	CDD:340989	141/480 (29%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	282..288		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337925
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740