DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1208 and Slc2a6

DIOPT Version :9

Sequence 1:	NP_001097692.1	Gene:	CG1208 / 40727	FlyBaseID:	FBgn0037386	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_766247.2	Gene:	Slc2a6 / 227659	MGIID:	2443286	Length:	497	Species:	Mus musculus

Alignment Length:	488	Identity:	141/488 - (28%)
Similarity:	248/488 - (50%)	Gaps:	41/488 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QENQSKTSKTRQYVAAMIICLGAVAAGTALSWTSPVFPQISAGNESSFNSTTGGISNSTSNENDI 98
            :|........|.::|.....||..:.|.||.:||||.|::                 ..|::..:
Mouse    26 RERAGALKNRRVFLATFAAVLGNFSFGYALVYTSPVIPEL-----------------KLSSDPAL 73

  Fly    99 RLTDSQKTLVGSMLPFGALFGALPSGYIADRIGRRYTAMVMDIPFILAWITLSFANSVGWLYLGR 163
            .|...|.:..||:...||..|.|.:..:.|.:||:.:.|...:|..:.:..::.|..:..|.|||
Mouse    74 HLDKIQASWFGSVFTLGAAAGGLSAMLLNDLLGRKLSIMFSAVPSAIGYAIMAGARGLWMLLLGR 138

  Fly   164 FLIGIATGSFCVVAPMYISEIAETSIRGSLGTLFQLLLTIGILFIYVVGALVSWKTLSLL---CL 225
            .|.|.|.|......|:|:||||...:||:||...||:...|.|.:|.:|.|:.|:.|::.   .:
Mouse   139 MLTGFAGGLTAACIPVYVSEIAPPDVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEGPV 203

  Fly   226 IIPILLLVGLFIVPETPVYLLKNGKRSEANRALKWLWGDYCNTSNAIQAIQNDLDQTGVDASVKD 290
            :|.|||   |..:|.:|.:||...:..||.:||.||..| .......:.||:::.:.....|..:
Mouse   204 LIMILL---LSFMPNSPRFLLSKSRDEEALQALTWLRAD-SEVHWEFEQIQDNVRRQSSRVSWAE 264

  Fly   291 LFSNRASRNGMVISVLLMVFQQFSGINAVIFFMNEIFESSSTLNPN-VCTIVVGVVQVIMTLASS 354
            ....|..| .::|:||:...||.:||..::.::..||:::|.:.|: ....:||.|:::..|.::
Mouse   265 AREPRVYR-PVLIAVLMRFLQQLTGITPILVYLQTIFDNTSVVLPSQQDAAIVGAVRLLSVLIAA 328

  Fly   355 LLIEKAGRKILLIFSSTIMTVCLAMLGAY-----------NTINRHTDLSQSIGWL---PLLCIV 405
            :.::.||||:||..|:::|......||.|           :|:...|....:..:|   |||..:
Mouse   329 VTMDLAGRKVLLYVSASVMFAANLTLGLYVQFVPRPLTPNSTVEIVTLGDTAFNYLTLIPLLATM 393

  Fly   406 LFIVSFSVGYGPIPWMMMGELFMPDVKGIAVSLSVMMNWVCVSLVT-WLFGVLNAGGADVPFWFF 469
            |||:.:::|:|||.|::|.|:.....:|:|..|.|:::|:...::| :....:||.|..|||:||
Mouse   394 LFIMGYAMGWGPITWLLMSEVLPLRARGVASGLCVLVSWLTAFVLTNYFLLAVNAFGLQVPFFFF 458

  Fly   470 SAWMGVATAYVAIALQETKGKSASQIQSWLSGR 502
            ||...::..:....:.||:|:|..||:::...|
Mouse   459 SAICLLSLLFTGCCVPETRGRSLEQIEAFFHTR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1208	NP_001097692.1	MFS	96..482	CDD:119392	120/404 (30%)
CG1208	NP_001097692.1	MFS_1	96..443	CDD:284993	108/364 (30%)
Slc2a6	NP_766247.2	Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS	38..483	CDD:391944	136/466 (29%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	284..290		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834421
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750