Protein Alignment Hpr1 and THOC1

DIOPT Version :10

• Sequence 1: NP_649594.1
• Gene: Hpr1 / 40723
• FlyBaseID: FBgn0037382
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: XP_011524074.1
• Gene: THOC1 / 9984
• HGNCID: 19070
• Length: 664
• Species: Homo sapiens
• Alignment Length: 705
• Identity: 260/705 - (36%)
• Similarity: 380/705 - (53%)
• Gaps: 96/705 - (13%)

  Fly    19 FALQSA---FEKALELAITDGKVELLVKEYNRFPANTEHDKRLPMDHAFRVLLMKRL--DEDVSR 78
            |:|..|   |.|:...|:.:..::.|:..:::.| .:|::|:..:|.|||.:|.:.:  ......
Human     8 FSLPEARTRFTKSTREALNNKNIKPLLSTFSQVP-GSENEKKCTLDQAFRGILEEEIINHSSCEN 71

  Fly    79 IGELVRLSVEATRAEIVSNTIPVVLLIDTFDVVTLDKCQKIFQFVEDMVEVWKEEIFFSSCKNNI 143
            :..::.|::......|.:.:.|.|||.|..|.:.||:|..||.|||..|..||...|:|:.||.:
Human    72 VLAIISLAIGGVTEGICTASTPFVLLGDVLDCLPLDQCDTIFTFVEKNVATWKSNTFYSAGKNYL 136

  Fly   144 LRMCNDLLRRLSRTQNTVFCGRIQLFLSKFFPFSERSGLNIVSEFNLDNFTEYGLD--------- 199
            ||||||||||||::|||||||||||||::.||.||:||||:.|:|||:|.|.:..:
Human   137 LRMCNDLLRRLSKSQNTVFCGRIQLFLARLFPLSEKSGLNLQSQFNLENVTVFNTNEQESTLGQK 201

  Fly   200 -SKDHDES-DNKELEDTAEDIP----LKIDYDLYCKFWSLQDFFRNPNQCYNKPQWKMFQMHADN 258
             ::|.:|. |.:|.|...|:.|    :.|||:||.|||||||:||||.|||.|..||.|..:::.
Human   202 HTEDREEGMDVEEGEMGDEEAPTTCSIPIDYNLYRKFWSLQDYFRNPVQCYEKISWKTFLKYSEE 266

  Fly   259 ILQSFSSFKLEDV---RQSSNENASGTDQAMDVDEEAVDTTAVSSVIKANHFFAKFLTNPKLLAL 320
            :|..|.|:||:|.   |:...|..:|.:..                     :||||||:.||:.|
Human   267 VLAVFKSYKLDDTQASRKKMEELKTGGEHV---------------------YFAKFLTSEKLMDL 310

  Fly   321 QLSDANFRRAVLVQFLILFQYLQVSVKFKSDTQTLTADQADFIKETESRVYKLLEETPPYGKRFS 385
            ||||:||||.:|:|:|||||||:..|||||....||.:|:.:|::|...||:||.|.||.|:|||
Human   311 QLSDSNFRRHILLQYLILFQYLKGQVKFKSSNYVLTDEQSLWIEDTTKSVYQLLSENPPDGERFS 375

  Fly   386 RTVYHMLAREEMWNNWKNEGCKEFKKPEEPTLSE--EDSKPTPNKRPRRPLGDALRDASRSGKFY 448
            :.|.|:|..||.||:||||||..|.|.....:.:  .|:|||...|.|....|.| ....:.|..
Human   376 KMVEHILNTEENWNSWKNEGCPSFVKESVCFVHDRTSDTKPTRIIRKRTAPEDFL-GKGPTKKIL 439

  Fly   449 LGNDNLTRLWNYSPDNLQACKSEQRNFLPLLETYLETPHEKVDPA--------------FEWRAL 499
            :||:.||||||..|||::|||||.|..:|.||.:.|...|:.||.              :.||||
Human   440 MGNEELTRLWNLCPDNMEACKSETREHMPTLEEFFEEAIEQADPENMVENEYKAVNNSNYGWRAL 504

  Fly   500 RLLARQTPHFFTSLSQPSSKISDYLEQVRKRLIRDKEPKPAALLSNNSSENNFGLSVNNVHTEGE 564
            |||||::||||...:|....:.:|||.:..:|.::..|         .||.
Human   505 RLLARRSPHFFQPTNQQFKSLPEYLENMVIKLAKELPP---------PSEE-------------- 546

  Fly   565 QDATVALQDGEPEQDLEVEDNEPVVEEVDEVPAHEKPLMVTKEHIEEVAPLIGEPWMKVGKKIGF 629
                  ::.||.|.:   |||:.:::| :|.|...:...||.|.||..|..:||.|..:...:..
Human   547 ------IKTGEDEDE---EDNDALLKE-NESPDVRRDKPVTGEQIEVFANKLGEQWKILAPYLEM 601

  Fly   630 TNDELLFFQMEHPTANVACVKMLTNWISDDD-DATLENWAYMLEGLEMNKAAEAV 683
            .:.|:...:.:.....:...::|..|...:. .||.||....|....::..||::
Human   602 KDSEIRQIECDSEDMKMRAKQLLVAWQDQEGVHATPENLINALNKSGLSDLAESL 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hpr1	NP_649594.1	efThoc1	81..538	CDD:463412	214/490 (44%)
		Death	606..687	CDD:459845	17/79 (22%)
THOC1	XP_011524074.1	efThoc1	74..546	CDD:463412	216/502 (43%)
		Death_NMPP84	572..657	CDD:260030	19/85 (22%)