Protein Alignment Hpr1 and thoc1

DIOPT Version :10

• Sequence 1: NP_649594.1
• Gene: Hpr1 / 40723
• FlyBaseID: FBgn0037382
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_958481.1
• Gene: thoc1 / 373077
• ZFINID: ZDB-GENE-030826-9
• Length: 655
• Species: Danio rerio
• Alignment Length: 705
• Identity: 259/705 - (36%)
• Similarity: 387/705 - (54%)
• Gaps: 90/705 - (12%)

  Fly    11 APEKLANYFALQSAFEKALELAITDGKVELLVKEYNRFPANTEHDKRLPMDHAFRVLLMKRLDED 75
            :|....::...:..|..|.:.|:.....:.|...::..|.| |.:|:..:|.|.|.:|.:::...
Zfish     2 SPPSHFDFIEARDKFTVATKNAVDTRNCKPLTTAFSHLPGN-ETEKKATLDQALRGVLEEQIVNQ 65

  Fly    76 VSRIGE---LVRLSVEATRAEIVSNTIPVVLLIDTFDVVTLDKCQKIFQFVEDMVEVWKEEIFFS 137
            ...:.:   |:.:|::.....|.|.|.|.:||.|..|.:.||:|.|||.|||:.|..||...|:|
Zfish    66 KVNVDDFLSLIYISIDGVTEGICSATTPFLLLGDVLDCLPLDQCDKIFSFVEENVSTWKSNTFYS 130

  Fly   138 SCKNNILRMCNDLLRRLSRTQNTVFCGRIQLFLSKFFPFSERSGLNIVSEFNLDNFTEYGLDSKD 202
            :.||.:||||||||||||::|||||||||||||::.||.||:||||:.|:|||||.|.:..:.:|
Zfish   131 AGKNYLLRMCNDLLRRLSKSQNTVFCGRIQLFLARLFPLSEKSGLNLQSQFNLDNITVFNKNEQD 195

  Fly   203 ------HDE-----SDNKELEDTAEDIP----LKIDYDLYCKFWSLQDFFRNPNQCYNKPQWKMF 252
                  |.|     .|.:|.|...||.|    :.|||:||.|||:|||:||||.|||:|..|..|
Zfish   196 STLGQQHTEVKEEGMDVEEGEMGDEDAPAPSSIPIDYNLYRKFWTLQDYFRNPVQCYDKFSWMTF 260

  Fly   253 QMHADNILQSFSSFKLEDVRQSSNENASGTDQAMDVDEEAVDTTAVSSVIKANHFFAKFLTNPKL 317
            ..::|..|..|.||||:|::.|..:            .|.:.|::...|     :||||||:.||
Zfish   261 IKYSDEALAVFKSFKLDDMQASKKK------------LEEMRTSSGDHV-----YFAKFLTSEKL 308

  Fly   318 LALQLSDANFRRAVLVQFLILFQYLQVSVKFKSDTQTLTADQADFIKETESRVYKLLEETPPYGK 382
            :.|||||:||||.:|:|:|||||||:..|||||.:..|..||:.:|::|...||:||:|.||.|.
Zfish   309 MDLQLSDSNFRRHILLQYLILFQYLKGQVKFKSSSCVLNDDQSLWIEDTTKLVYQLLKEIPPDGD 373

  Fly   383 RFSRTVYHMLAREEMWNNWKNEGCKEFKKPEEPTLSEEDSKPTPNKRPRRPLGDAL-RDASRSGK 446
            :|...|.|:|..||.||:||||||..|.| |.|.    ::||....|.|:...|.| :...|  |
Zfish   374 KFGSMVEHILNTEENWNSWKNEGCPSFVK-ERPA----ETKPIRPSRKRQAPEDFLGKGPDR--K 431

  Fly   447 FYLGNDNLTRLWNYSPDNLQACKSEQRNFLPLLETYLETPHEKVDPA--------------FEWR 497
            ..:|||.||||||.:|||::|||||.|.|:|.||.:.|...|:.|||              :.||
Zfish   432 ILMGNDELTRLWNLNPDNMEACKSENREFMPSLEDFFEEAIEQADPANMVEDEYKVVRNSNYGWR 496

  Fly   498 ALRLLARQTPHFFTSLSQPSSKISDYLEQVRKRLIRDKEPKPAALLSNNSSENNFGLSVNNVHTE 562
            |||||:|::||||...:|....::||||.:..:|.::. ||                   ::.:|
Zfish   497 ALRLLSRRSPHFFQPTNQQFKSLADYLENMVIKLAKEL-PK-------------------DIPSE 541

  Fly   563 GEQDATVALQDGEPEQDLEVEDNEPVVEEVDEVPAHEKPLMVTKEHIEEVAPLIGEPWMKVGKKI 627
                   .::.||.:.|   |:.:.::::.::.|:.:.. .||...::|:|..:|..|..:...:
Zfish   542 -------EIKTGEEDDD---ENGDNLLKDSNDSPSIQSK-AVTNSQMDEIAAKLGSQWKTLADHL 595

  Fly   628 GFTNDELLFFQMEHPTANVACVKMLTNWIS-DDDDATLENWAYMLEGLEMNKAAE 681
            ..::.|:...:.:....::....:|..|.. :...||:|:....|.....|..|:
Zfish   596 EMSDKEIRVIESDSEDVDLQAKMLLVAWQDREGSQATMESLVTALNAAGFNNIAD 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hpr1	NP_649594.1	efThoc1	81..538	CDD:463412	223/489 (46%)
		Death	606..687	CDD:459845	13/77 (17%)
thoc1	NP_958481.1	efThoc1	71..537	CDD:463412	225/509 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	403..427		8/27 (30%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q96FV9	415..431		5/17 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	539..574		7/45 (16%)
		Death_NMPP84	568..653	CDD:260030	15/84 (18%)