Protein Alignment Hpr1 and thoc1

DIOPT Version :9

• Sequence 1: NP_649594.1
• Gene: Hpr1 / 40723
• FlyBaseID: FBgn0037382
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_958481.1
• Gene: thoc1 / 373077
• ZFINID: ZDB-GENE-030826-9
• Length: 655
• Species: Danio rerio
• Alignment Length: 705
• Identity: 259/705 - (36%)
• Similarity: 387/705 - (54%)
• Gaps: 90/705 - (12%)

  Fly    11 APEKLANYFALQSAFEKALELAITDGKVELLVKEYNRFPANTEHDKRLPMDHAFRVLLMKRLDED 75
            :|....::...:..|..|.:.|:.....:.|...::..|.| |.:|:..:|.|.|.:|.:::...
Zfish     2 SPPSHFDFIEARDKFTVATKNAVDTRNCKPLTTAFSHLPGN-ETEKKATLDQALRGVLEEQIVNQ 65

  Fly    76 VSRIGE---LVRLSVEATRAEIVSNTIPVVLLIDTFDVVTLDKCQKIFQFVEDMVEVWKEEIFFS 137
            ...:.:   |:.:|::.....|.|.|.|.:||.|..|.:.||:|.|||.|||:.|..||...|:|
Zfish    66 KVNVDDFLSLIYISIDGVTEGICSATTPFLLLGDVLDCLPLDQCDKIFSFVEENVSTWKSNTFYS 130

  Fly   138 SCKNNILRMCNDLLRRLSRTQNTVFCGRIQLFLSKFFPFSERSGLNIVSEFNLDNFTEYGLDSKD 202
            :.||.:||||||||||||::|||||||||||||::.||.||:||||:.|:|||||.|.:..:.:|
Zfish   131 AGKNYLLRMCNDLLRRLSKSQNTVFCGRIQLFLARLFPLSEKSGLNLQSQFNLDNITVFNKNEQD 195

  Fly   203 ------HDE-----SDNKELEDTAEDIP----LKIDYDLYCKFWSLQDFFRNPNQCYNKPQWKMF 252
                  |.|     .|.:|.|...||.|    :.|||:||.|||:|||:||||.|||:|..|..|
Zfish   196 STLGQQHTEVKEEGMDVEEGEMGDEDAPAPSSIPIDYNLYRKFWTLQDYFRNPVQCYDKFSWMTF 260

  Fly   253 QMHADNILQSFSSFKLEDVRQSSNENASGTDQAMDVDEEAVDTTAVSSVIKANHFFAKFLTNPKL 317
            ..::|..|..|.||||:|::.|..:            .|.:.|::...|     :||||||:.||
Zfish   261 IKYSDEALAVFKSFKLDDMQASKKK------------LEEMRTSSGDHV-----YFAKFLTSEKL 308

  Fly   318 LALQLSDANFRRAVLVQFLILFQYLQVSVKFKSDTQTLTADQADFIKETESRVYKLLEETPPYGK 382
            :.|||||:||||.:|:|:|||||||:..|||||.:..|..||:.:|::|...||:||:|.||.|.
Zfish   309 MDLQLSDSNFRRHILLQYLILFQYLKGQVKFKSSSCVLNDDQSLWIEDTTKLVYQLLKEIPPDGD 373

  Fly   383 RFSRTVYHMLAREEMWNNWKNEGCKEFKKPEEPTLSEEDSKPTPNKRPRRPLGDAL-RDASRSGK 446
            :|...|.|:|..||.||:||||||..|.| |.|.    ::||....|.|:...|.| :...|  |
Zfish   374 KFGSMVEHILNTEENWNSWKNEGCPSFVK-ERPA----ETKPIRPSRKRQAPEDFLGKGPDR--K 431

  Fly   447 FYLGNDNLTRLWNYSPDNLQACKSEQRNFLPLLETYLETPHEKVDPA--------------FEWR 497
            ..:|||.||||||.:|||::|||||.|.|:|.||.:.|...|:.|||              :.||
Zfish   432 ILMGNDELTRLWNLNPDNMEACKSENREFMPSLEDFFEEAIEQADPANMVEDEYKVVRNSNYGWR 496

  Fly   498 ALRLLARQTPHFFTSLSQPSSKISDYLEQVRKRLIRDKEPKPAALLSNNSSENNFGLSVNNVHTE 562
            |||||:|::||||...:|....::||||.:..:|.::. ||                   ::.:|
Zfish   497 ALRLLSRRSPHFFQPTNQQFKSLADYLENMVIKLAKEL-PK-------------------DIPSE 541

  Fly   563 GEQDATVALQDGEPEQDLEVEDNEPVVEEVDEVPAHEKPLMVTKEHIEEVAPLIGEPWMKVGKKI 627
                   .::.||.:.|   |:.:.::::.::.|:.:.. .||...::|:|..:|..|..:...:
Zfish   542 -------EIKTGEEDDD---ENGDNLLKDSNDSPSIQSK-AVTNSQMDEIAAKLGSQWKTLADHL 595

  Fly   628 GFTNDELLFFQMEHPTANVACVKMLTNWIS-DDDDATLENWAYMLEGLEMNKAAE 681
            ..::.|:...:.:....::....:|..|.. :...||:|:....|.....|..|:
Zfish   596 EMSDKEIRVIESDSEDVDLQAKMLLVAWQDREGSQATMESLVTALNAAGFNNIAD 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hpr1	NP_649594.1	efThoc1	79..538	CDD:288785	223/491 (45%)
		Death	606..687	CDD:278932	13/77 (17%)
thoc1	NP_958481.1	efThoc1	74..544	CDD:288785	226/520 (43%)
		Death_NMPP84	568..653	CDD:260030	15/84 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574585
Domainoid	1	1.000	398	1.000	Domainoid score	I713
eggNOG	1	0.900	-	-		E1_KOG2491
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38012
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1767
OMA	1	1.010	-	-		QHG58811
OrthoDB	1	1.010	-	-		D148325at33208
OrthoFinder	1	1.000	-	-		FOG0005707
OrthoInspector	1	1.000	-	-		oto39322
orthoMCL	1	0.900	-	-		OOG6_103415
Panther	1	1.100	-	-	LDO	PTHR13265
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1913
SonicParanoid	1	1.000	-	-		X4105
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800