Protein Alignment Hpr1 and Thoc1

DIOPT Version :10

• Sequence 1: NP_649594.1
• Gene: Hpr1 / 40723
• FlyBaseID: FBgn0037382
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_001385566.1
• Gene: Thoc1 / 291797
• RGDID: 1308657
• Length: 657
• Species: Rattus norvegicus
• Alignment Length: 711
• Identity: 258/711 - (36%)
• Similarity: 380/711 - (53%)
• Gaps: 115/711 - (16%)

  Fly    19 FALQSA---FEKALELAITDGKVELLVKEYNRFPANTEHDKRLPMDHAFRVLLMKRLDEDV---- 76
            |:|..|   |.|:...|:.:..::.|:..:::.| .:|::|:..:|.|||.:    |:|::
  Rat     8 FSLPEARTRFTKSTREALNNKTIKPLLNAFSQLP-GSENEKKCTLDQAFRGV----LEEEIINHS 67

  Fly    77 --SRIGELVRLSVEATRAEIVSNTIPVVLLIDTFDVVTLDKCQKIFQFVEDMVEVWKEEIFFSSC 139
              ..:..::.|::......:.:.:.|.|||.|..|.:.||:|..||.|||..|..||...|:|:.
  Rat    68 ACENVLAIISLAIGGVTESVCTASTPFVLLGDVLDCLPLDQCDTIFTFVEKNVATWKSNTFYSAG 132

  Fly   140 KNNILRMCNDLLRRLSRTQNTVFCGRIQLFLSKFFPFSERSGLNIVSEFNLDNFTEYGLDSKD-- 202
            ||.:||||||||||||::|||||||||||||::.||.||:||||:.|:|||:|.|.:..:.::
  Rat   133 KNYLLRMCNDLLRRLSKSQNTVFCGRIQLFLARLFPLSEKSGLNLQSQFNLENITVFNTNEQEST 197

  Fly   203 ------HDESDNKELED---------TAEDIPLKIDYDLYCKFWSLQDFFRNPNQCYNKPQWKMF 252
                  .|..:..::|:         |...||  |||:||.|||||||:||||.|||.|..||.|
  Rat   198 LGQKHTEDREEGMDVEEGEMGDDEAPTTCSIP--IDYNLYRKFWSLQDYFRNPVQCYEKISWKTF 260

  Fly   253 QMHADNILQSFSSFKLEDV---RQSSNENASGTDQAMDVDEEAVDTTAVSSVIKANHFFAKFLTN 314
            ..:::.:|..|.|:||:|.   |:...|..:|.:..                     :||||||:
  Rat   261 LKYSEEVLAVFKSYKLDDTQASRKKMEELKTGGEHV---------------------YFAKFLTS 304

  Fly   315 PKLLALQLSDANFRRAVLVQFLILFQYLQVSVKFKSDTQTLTADQADFIKETESRVYKLLEETPP 379
            .||:.|||||:||||.:|:|:|||||||:..|||||....||.:|:.:|::|...||:||.|.||
  Rat   305 EKLMDLQLSDSNFRRHILLQYLILFQYLKGQVKFKSSNYVLTDEQSLWIEDTTKSVYQLLSENPP 369

  Fly   380 YGKRFSRTVYHMLAREEMWNNWKNEGCKEFKKPEEPTLSEEDSKPTPNKRPRRPLGDALRDASRS 444
            .|:|||:.|.|:|..||.||:||||||..|.|..     ..|:|||...|.|....|.|......
  Rat   370 DGERFSKMVEHILNTEENWNSWKNEGCPSFVKER-----ASDTKPTRVVRKRAAPEDFLGKGPNK 429

  Fly   445 GKFYLGNDNLTRLWNYSPDNLQACKSEQRNFLPLLETYLETPHEKVDPA--------------FE 495
             |..:||:.||||||..|||::|||||.|.::|.||.:.|...|:.||.              :.
  Rat   430 -KILIGNEELTRLWNLCPDNMEACKSETREYMPTLEEFFEEAIEQADPENMVESEYKAVNNSNYG 493

  Fly   496 WRALRLLARQTPHFFTSLSQPSSKISDYLEQVRKRLIRDKEPKPAALLSNNSSENNFGLSVNNVH 560
            |||||||||::||||...:|....:.:|||.:..:|.::..|         .||.
  Rat   494 WRALRLLARRSPHFFQPTNQQFKSLPEYLENMVIKLAKELPP---------PSEE---------- 539

  Fly   561 TEGEQDATVALQDGEPEQDLEVEDNEPVVEEVDEVP--AHEKPLMVTKEHIEEVAPLIGEPWMKV 623
                      ::.||.|.:   |||:.:::| :|.|  ..:|||  |.|.||..|..:||.|..:
  Rat   540 ----------IKTGEDEDE---EDNDALLKE-NESPDVRRDKPL--TGEQIESFANKLGEQWKIL 588

  Fly   624 GKKIGFTNDELLFFQMEHPTANVACVKMLTNWISDDD-DATLENWAYMLEGLEMNKAAEAV 683
            ...:...:.::...:.:.....:...::|..|...:. .||.:|....|....::..||::
  Rat   589 APYLEIKDSDIRQIECDSEDMKMRAKQLLVAWQDQEGVHATTDNLIGALNKSGLSDLAESL 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hpr1	NP_649594.1	efThoc1	81..538	CDD:463412	211/490 (43%)
		Death	606..687	CDD:459845	15/79 (19%)
Thoc1	NP_001385566.1	efThoc1	74..539	CDD:463412	213/502 (42%)
		Death_NMPP84	565..650	CDD:260030	19/87 (22%)