Protein Alignment Hpr1 and Thoc1

DIOPT Version :10

• Sequence 1: NP_649594.1
• Gene: Hpr1 / 40723
• FlyBaseID: FBgn0037382
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_001404674.1
• Gene: Thoc1 / 225160
• MGIID: 1919668
• Length: 682
• Species: Mus musculus
• Alignment Length: 730
• Identity: 260/730 - (35%)
• Similarity: 379/730 - (51%)
• Gaps: 128/730 - (17%)

  Fly    19 FALQSA---FEKALELAITDGKVELLVKEYNRFPANTEHDKRLPMDHAFRVLLMKRL-----DED 75
            |:|..|   |.|:...|:.:..::.|:..:::.| .:|::|:..:|.|||.:|.:.:     .|:
Mouse     8 FSLPEARTRFTKSTREALNNKNIKPLLTAFSQLP-GSENEKKCTLDQAFRGVLEEEIINHSACEN 71

  Fly    76 VSRIGELVRLSVEAT---------RAEIVSNTI-------------PVVLLIDTFDVVTLDKCQK 118
            |..|..|....|..|         ...:.|:::             |.|||.|..|.:.||:|..
Mouse    72 VLAIISLAIGGVTETCPWILFLVLEGSVTSSSLIYTPFVGVCTASTPFVLLGDVLDCLPLDQCDT 136

  Fly   119 IFQFVEDMVEVWKEEIFFSSCKNNILRMCNDLLRRLSRTQNTVFCGRIQLFLSKFFPFSERSGLN 183
            ||.|||..|..||...|:|:.||.:||||||||||||::|||||||||||||::.||.||:||||
Mouse   137 IFTFVEKNVATWKSNTFYSAGKNYLLRMCNDLLRRLSKSQNTVFCGRIQLFLARLFPLSEKSGLN 201

  Fly   184 IVSEFNLDNFTEYGLDSKD--------HDESDNKELED---------TAEDIPLKIDYDLYCKFW 231
            :.|:|||:|.|.:..:.::        .|..:..::|:         |...||  |||:||.|||
Mouse   202 LQSQFNLENVTVFNTNEQESTLGQKHTEDREEGMDVEEGEMGDDEAPTTCSIP--IDYNLYRKFW 264

  Fly   232 SLQDFFRNPNQCYNKPQWKMFQMHADNILQSFSSFKLEDV---RQSSNENASGTDQAMDVDEEAV 293
            ||||:||||.|||.|..||.|..:::.:|..|.|:||:|.   |:...|..:|.:..
Mouse   265 SLQDYFRNPVQCYEKISWKTFLKYSEEVLAVFKSYKLDDTQASRKKMEELKTGGEHV-------- 321

  Fly   294 DTTAVSSVIKANHFFAKFLTNPKLLALQLSDANFRRAVLVQFLILFQYLQVSVKFKSDTQTLTAD 358
                         :||||||:.||:.|||||:||||.:|:|:|||||||:..|||||....||.:
Mouse   322 -------------YFAKFLTSEKLMDLQLSDSNFRRHILLQYLILFQYLKGQVKFKSSNYVLTDE 373

  Fly   359 QADFIKETESRVYKLLEETPPYGKRFSRTVYHMLAREEMWNNWKNEGCKEFKKPEEPTLSEEDSK 423
            |:.:|::|...||:||.|.||.|:|||:.|.|:|..||.||:||||||..|.|..     ..|:|
Mouse   374 QSLWIEDTTKSVYQLLSENPPDGERFSKMVEHILNTEENWNSWKNEGCPSFVKER-----ASDTK 433

  Fly   424 PTPNKRPRRPLGDALRDASRSGKFYLGNDNLTRLWNYSPDNLQACKSEQRNFLPLLETYLETPHE 488
            ||...|.|....|.|...... |..:||:.||||||..|||::|||||.|.::|.||.:.|...|
Mouse   434 PTRVVRKRAAPEDFLGKGPNK-KILIGNEELTRLWNLCPDNMEACKSETREYMPTLEEFFEEAIE 497

  Fly   489 KVDPA--------------FEWRALRLLARQTPHFFTSLSQPSSKISDYLEQVRKRLIRDKEPKP 539
            :.||.              :.|||||||||::||||...:|....:.:|||.:..:|.::..|
Mouse   498 QADPENMVESEYKAVNNSNYGWRALRLLARRSPHFFQPTNQQFKSLPEYLENMVIKLAKELPP-- 560

  Fly   540 AALLSNNSSENNFGLSVNNVHTEGEQDATVALQDGEPEQDLEVEDNEPVVEEVDEVPAHEKPLMV 604
                   .||.                    ::.||.|.:   |||:.:::| :|.|...:...:
Mouse   561 -------PSEE--------------------IKTGEDEDE---EDNDALLKE-NESPDVRRDKPI 594

  Fly   605 TKEHIEEVAPLIGEPWMKVGKKIGFTNDELLFFQMEHPTANVACVKMLTNWISDDD-DATLENWA 668
            |.|.||..|..:||.|..:...:...:.::...:.:.....:...::|..|...:. .||.:|..
Mouse   595 TGEQIESFANKLGEQWKILAPYLEIKDSDIRQIECDSEDMKMRAKQLLVAWQDQEGVHATTDNLI 659

  Fly   669 YMLEGLEMNKAAEAV 683
            ..|....::..||::
Mouse   660 SALNKSGLSDLAESL 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hpr1	NP_649594.1	efThoc1	81..538	CDD:463412	214/512 (42%)
		Death	606..687	CDD:459845	15/79 (19%)
Thoc1	NP_001404674.1	efThoc1	113..564	CDD:463412	212/488 (43%)
		Death_NMPP84	590..675	CDD:260030	16/85 (19%)