DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hpr1 and thoc-1

DIOPT Version :9

Sequence 1:	NP_649594.1	Gene:	Hpr1 / 40723	FlyBaseID:	FBgn0037382	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_493796.2	Gene:	thoc-1 / 173460	WormBaseID:	WBGene00020172	Length:	665	Species:	Caenorhabditis elegans

Alignment Length:	742	Identity:	214/742 - (28%)
Similarity:	349/742 - (47%)	Gaps:	147/742 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EKALELAITDGKVELLVKEYNRFPANTEHDKRLPMDHAFRVLLMKRLDEDVSRIGELVRLSVEAT 90
            |..:|....||..|::..|           |:...|..| |||  ::|..:.:.|..|.....||
Worm     2 ETVIENRDLDGLKEVVKAE-----------KKTAKDDEF-VLL--KVDGFLKKRGFKVAEQPSAT 52

  Fly    91 RAEIV----------------SNTIPVVLLIDTFDVVTLDKCQKIFQFVEDMVEVWKEEIFFSSC 139
            :.|:.                |...|:..|.|..::.::::|::||..||:.:..:|:..|..:.
Worm    53 KEELARRHFHFVMNCSKLGLCSKNTPLSTLQDLLEMSSIEECKQIFSIVEENMNEFKQPGFIETA 117

  Fly   140 KNNILRMCNDLLRRLSRTQNTVFCGRIQLFLSKFFPFSERSGLNIVSEFNLDNFTEYGLDSKDHD 204
            :|||||.|||||||||||..|.|||||..|||:|.|.:|:||:|.:..||..|.|.|     |..
Worm   118 QNNILRFCNDLLRRLSRTAETSFCGRIMFFLSRFLPLTEKSGVNFMGHFNTLNVTNY-----DES 177

  Fly   205 ESDNKEL-----------------------EDTAEDIPLKIDYDLYCKFWSLQDFFRNPNQCYNK 246
            |:|.:.|                       ||.:::|  ::..::|.:|||||.|..|||..|.|
Worm   178 ETDGEALLAATSSAPTPTEGAEDMETGEIEEDNSKEI--QVTPEMYRQFWSLQKFMSNPNSIYEK 240

  Fly   247 PQWKMFQMHADNILQSFSSFKLEDVRQSSNENASGTDQAMDVDEEAVDTTAVSSVIKANHFFAKF 311
            .::..|:.....:|...:|.|||  :.||.|     ::|::..::.....:.:.|     ||.|:
Worm   241 EKFLTFKTDLTAVLTLMTSNKLE--KLSSEE-----EEALENRQKKQQKGSSNDV-----FFTKY 293

  Fly   312 LTNPKLLALQLSDANFRRAVLVQFLILFQYLQVSVKFK--SDTQTLTADQADFIKETESRVYKLL 374
            ||:||||||||:|::|||..|:|.:|:||||....:||  :....|..|||.::.|.|.:.|:||
Worm   294 LTSPKLLALQLNDSSFRRYFLMQAIIIFQYLTAESRFKPPAKKMVLNEDQAKYVSECEDKCYRLL 358

  Fly   375 EETPPYGKRFSRTVYHMLAREEMWNNWKNEGCKEFKKPEEPTLSEEDSKPTPNKRPRRPLGDALR 439
            .:|.|.|..|...:..::.||:.||.|||..|.:|.:.     :::.:.....||.|.|......
Worm   359 ADTMPRGTAFVAGLKRIMLREQEWNTWKNANCADFSEK-----ADKGAMQMYKKRQRIPFNPNSL 418

  Fly   440 DASRSGKFYLGNDNLTRLWNYSPDNLQACKSEQRNFLPLLETYLETPHEKVDP------------ 492
            |        ||...||:||...||.|:||||::|.|:|.|..::..|.:::||
Worm   419 D--------LGTPELTKLWTNEPDVLKACKSDKRKFIPKLPDFIRDPIDEMDPEQQVEEQYKQIN 475

  Fly   493 --AFEWRALRLLARQTPHFFT---SLSQPSSKISDYLEQVRKRLIRDKEPKPAALLSNNSSENNF 552
              ||:|||.|||..::|.:.|   :.:.|::.|.::||:              .:.:...:.|.|
Worm   476 DSAFQWRAARLLMHKSPGYVTKTDTKTDPTTNIKEFLER--------------NMYNAAKNFNEF 526

  Fly   553 GLSVNNVHTEGEQDATVALQDGEPEQDLEVE-DNEPVVEEVDEVPAHEKPLMVTKEHIEEVAPLI 616
            ..|:.| ..:.|.:|...:     |:.|:.: |:..|.......|......:::.||:.::|..:
Worm   527 KESIEN-REKKEAEARKKV-----EESLKRKLDSSKVKPSQTSSPNPYTDTILSDEHLTQLARDL 585

  Fly   617 GEPWMKVGKKIG-------FTNDELLFFQMEHPTANVACVKMLTNWISDD---DDATLENWAYML 671
            .:....:.|..|       .|:||.:            |.|:|.:|...:   ..:.|......|
Worm   586 SKFKSNLAKCFGTKLPADDVTSDEKI------------CFKILKSWAEKNGRSGRSLLNTLITDL 638

  Fly   672 EGLEMNKAAEAVKAIIEREKSGSTAAF 698
            :.:|:.:|:..|:...|:.|:.|..:|
Worm   639 DVIEVAQASMKVRFFSEKMKNFSEKSF 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hpr1	NP_649594.1	efThoc1	79..538	CDD:288785	169/516 (33%)
Hpr1	NP_649594.1	Death	606..687	CDD:278932	17/90 (19%)
thoc-1	NP_493796.2	efThoc1	63..492	CDD:288785	158/460 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156559
Domainoid	1	1.000	274	1.000	Domainoid score	I942
eggNOG	1	0.900	-	-		E1_KOG2491
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38012
Inparanoid	1	1.050	274	1.000	Inparanoid score	I1796
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58811
OrthoDB	1	1.010	-	-		D148325at33208
OrthoFinder	1	1.000	-	-		FOG0005707
OrthoInspector	1	1.000	-	-		oto17372
orthoMCL	1	0.900	-	-		OOG6_103415
Panther	1	1.100	-	-	LDO	PTHR13265
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1913
SonicParanoid	1	1.000	-	-		X4105
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800