DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42675 and ZC2HC1C

DIOPT Version :9

Sequence 1:	NP_001262302.1	Gene:	CG42675 / 40722	FlyBaseID:	FBgn0261561	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_078919.2	Gene:	ZC2HC1C / 79696	HGNCID:	20354	Length:	456	Species:	Homo sapiens

Alignment Length:	342	Identity:	75/342 - (21%)
Similarity:	120/342 - (35%)	Gaps:	126/342 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 WAARRLMEALSHLPPSGNSSTNSAPMRFQQRTQQEQEVRRRELM------STKSSAENLATGAPS 96
            |...|.:||      :|.|              .|:|:||::::      .|:.....:.|....
Human   210 WVQIRRLEA------AGES--------------LEEEIRRKQILLRGKLKKTEEELRRIQTQKEQ 254

  Fly    97 AATTRLIGNGKVRQMFDERRRGAGIDRSNPL-KPIGTLPSPP-------------------AQTK 141
            |....   ||:::::...|.|..| ::||.: |||.   ||.                   :|..
Human   255 AKENE---NGELQKIILPRSRVKG-NKSNTMYKPIF---SPEFEFEEEFSRDRREDETWGRSQQN 312

  Fly   142 SRP----QPPMQRLVKGVADLTMRDAPNAPGRRITSDSNNNKFATPRGTLNRNLKPVVTRKTPPA 202
            |.|    ...:|||                 :|....::|||...|..      :|.|.:.:||:
Human   313 SGPFQFSDYRIQRL-----------------KRERLVASNNKIRDPVS------EPSVEKFSPPS 354

  Fly   203 QETTLHQRSPAPQRSPKIQATQRVSGGTGAAPTAGRLSPPFVRRAEPKSPVKKVNMDTTTAIPEG 267
            :......:..|...|..:......|.|:...|..|.
Human   355 ETPVGALQGSARNSSLSMAPDSSGSSGSIEEPQLGE----------------------------- 390

  Fly   268 TALCRYCGRHFNTDRLAKHEEVCQRMLTTKRKIFDASKQRIEGTEAAAF-NMKSKGNRNRSTYSS 331
               |.:|||.|.:.||.:|..:|.||..:|||:||:|:.|.:|||...: |.|...       |:
Human   391 ---CSHCGRKFLSFRLERHSNICSRMRGSKRKVFDSSRARAKGTELEQYLNWKGPA-------SA 445

  Fly   332 AAQQKGLTTGVKKNNWR 348
            .|:..      :|:|||
Human   446 KAEPP------QKSNWR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42675	NP_001262302.1	zf-C2HC_2	271..291	CDD:290624	8/19 (42%)
CG42675	NP_001262302.1	zf-C2HC_2	389..410	CDD:290624
ZC2HC1C	NP_078919.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..46
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..388		12/57 (21%)
		zf-C2HC_2	387..411	CDD:290624	9/55 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3940
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108928
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1390
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.670