DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10979 and znf800a

DIOPT Version :9

Sequence 1:	NP_001262301.1	Gene:	CG10979 / 40720	FlyBaseID:	FBgn0037379	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001311478.1	Gene:	znf800a / 568719	ZFINID:	ZDB-GENE-041008-151	Length:	708	Species:	Danio rerio

Alignment Length:	767	Identity:	141/767 - (18%)
Similarity:	247/767 - (32%)	Gaps:	318/767 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DISLLQRPLRTAHTGFEEARRAYEDGTSEVRQLLSLECSLIYECKVCRNMFRSLANFISHKRVFC 88
            |..|||:.|:|:.:|..:....:..||::::|:|..|...|:|||:||::||.|.|.::||.::|
Zfish    50 DPPLLQQQLQTSKSGIHQIIECFRSGTAQLKQMLLKEVDTIFECKICRSLFRGLPNLVTHKELYC 114

  Fly    89 CVSARSANGSGYTDQNSTMIIQTGGGPSPQDIEHMLRSRSTGCSPVPRDVRPLRGGGGGGIRD-L 152
                       ::.|                               |:...|.:||....|:: |
Zfish   115 -----------FSQQ-------------------------------PQSDDPSKGGQSHAIKELL 137

  Fly   153 SGVIERLRREKATSQAKCSSPTVLQLESVPNSSQAVYQTIKV----------------------- 194
            ..:..:..:||.|          :|||::..:..||:|.:.:
Zfish   138 QAIYPQKEQEKQT----------IQLEAIETNPNAVFQHVSLGEIQDMPESPAPTTTAPAPVPEI 192

  Fly   195 ---------------------DHDDSIRTELDEVHRMLNPSETIVGPDGKALATVKLENNAGSDS 238
                                 |.:|.:.||::|     .|:..  ||  .....:|:|   |.:.
Zfish   193 LLPEKKNRRKSILAPKKVQQSDFEDEMETEVEE-----QPANE--GP--SCDEQMKIE---GEEE 245

  Fly   239 GEQSISDET-EPSIFCEICNLTFQTHKTLEVHIQKHH------------------SSSAFV---- 280
            .|:|.:.|. |..|.|.:|...|.:.:::..|.:|.|                  |..:.|
Zfish   246 EEESAASEVKELRISCCLCGKDFGSRRSVRRHCRKMHWQRMEELRKFTETRTVPISLLSVVKDKH 310

  Fly   281 ---------FQCPACSLTFLQAAAVIRHLSKDHKKPTRRIRMMRNTILKRRIQQGDV-------- 328
                     ..||.|..:|...|.|.||..:.|:.            |||.:...|:
Zfish   311 PVEPPPSPGKSCPVCKKSFATKANVRRHFDEVHRG------------LKRDLITPDIATRPGQPL 363

  Fly   329 -----QPKGPCRELKRLQLSDDVVGYVP-EPLDASGEHRKIMSL-CIYCEKSFERRAALSTHLLN 386
                 .|..|.:              || .||........:.|. |..|::.:..:..|..|:
Zfish   364 LLDTPSPPSPAK--------------VPSSPLKQEKPQYNLTSCRCKLCKRKYSSQLMLRRHM-- 412

  Fly   387 CRAKQEALAKPAPSVKKLKMKSNDSSVDAADEDPTTSIDLPKKKPIKTEEITLNEMFADLPEPND 451
                  .:....|:::....||. |..:..|           |..:|.|.::
Zfish   413 ------RIVHKIPTLENSSQKSK-SKQERRD-----------KVYVKKESLS------------- 446

  Fly   452 SFAPGLHTVSLDQLNLGNVSDSASDEASNTDDEHELTPGAGPESNADAEDVKGKAKKKRNVPVEK 516
                                 .||::..|               .:.:.|.|
Zfish   447 ---------------------KASEDDGN---------------QSVSFDFK------------- 462

  Fly   517 QLRCRCKICHKQFNALGNLRRHISMFH-----------YRARRFGCNLCEYRAFRRYDIVNHLGF 570
              |..|.:|.:||:...||.:||:..|           ||     |.:|.|.:.|:.|::.|:..
Zfish   463 --RIYCWLCKRQFSTSYNLGKHIAELHTDGNDSIYIKFYR-----CPICRYESRRKRDVIRHITV 520

  Fly   571 THKIEGDRDQLTEQYVSTHECEYSRDDVDGDIILLDKEEELTVMEKDA--KPPIKTYERRLKHLK 633
            .||       .:.:|::                     :.:..:|..|  ||.........|.:.
Zfish   521 VHK-------KSSRYLA---------------------KVMPALENQAVKKPADAILSSASKKIN 557

  Fly   634 TLTESVGEVQPKSPTAAIKEEPGQEPLEGTPTPSKKRRKSRTQISPESGEHS 685
            ...:..|:.:.:.|.|:....  |:.|..:|    |.:|..:|.||.:.:||
Zfish   558 AKEDGSGKHKTQDPPASPSSR--QQDLLVSP----KAKKQESQTSPNTRKHS 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10979	NP_001262301.1	C2H2 Zn finger	253..273	CDD:275368	4/19 (21%)
		C2H2 Zn finger	283..300	CDD:275368	7/16 (44%)
		C2H2 Zn finger	522..543	CDD:275368	8/20 (40%)
znf800a	NP_001311478.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587280
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	83	1.000	Inparanoid score	I5168
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007890
OrthoInspector	1	1.000	-	-		otm25313
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21020
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5550
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.020