DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10979 and Zfp800

DIOPT Version :9

Sequence 1:	NP_001262301.1	Gene:	CG10979 / 40720	FlyBaseID:	FBgn0037379	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	XP_038964031.1	Gene:	Zfp800 / 500057	RGDID:	1560157	Length:	717	Species:	Rattus norvegicus

Alignment Length:	849	Identity:	171/849 - (20%)
Similarity:	289/849 - (34%)	Gaps:	262/849 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRKRSSRCNSDTFKEEQMDHNG----------DDISLLQRPLRTAHTGFEEARRAYEDGTSEVRQ 55
            |..|...|.:|      ..|:|          .|..|||:|::|:.:|.::....:..||.:::.
  Rat     1 MPLRDKYCQTD------HHHHGCCEPVYILEPGDPPLLQQPVQTSKSGIQQIIECFRSGTKQLKH 59

  Fly    56 LLSLECSLIYECKVCRNMFRSLANFISHKRVFCCVSAR-SANGSGYTDQNSTMI--IQTGGGPSP 117
            :|..:...|:|||:||::||.|.|.|:||:.:|..|.: ..|.....|:.|..|  :.....|..
  Rat    60 ILLKDVDTIFECKLCRSLFRGLPNLITHKKFYCPPSLQMDDNLPDVNDKQSQAISDLLEAIYPRV 124

  Fly   118 QDIEHMLRSRSTGCSPVPRDVRPLRGGGGGGIRDLSGVIERLRREKATSQAKCSSPTVLQLE--- 179
            ...|::::            :.|:.       .:.:.|.:.:.|....::...||.|..|.|
  Rat   125 DKREYIIK------------LEPIE-------TNQNAVFQYISRTDNPAEVTESSSTPEQTEVQI 170

  Fly   180 ---------SVPNSSQAVYQTIKVDHDDSIRTELDEVHRMLNPSETIVGPDGKALATVKLENNAG 235
                     :||.:...|.:.|:   ...:.|..||.   ..|:|     :....:...||.:..
  Rat   171 QETSSEQPKAVPEADTEVEEAIE---PPPVETVADEA---TAPTE-----EQPQESQADLETSDS 224

  Fly   236 SDSGEQSISDETEPSIFCEICNLTFQTHKTLEVHIQKHH------------------------SS 276
            ||.|.|         :.|.:|...|.:.:.:..||:|.|                        |.
  Rat   225 SDLGHQ---------LICCLCRKEFNSRRGVRRHIRKVHKKKMEELKKYIETRKTPNQSSKGRSK 280

  Fly   277 SAFVF---QCPACSLTFLQAAAVIRHLSKDHKKPTRRIRMMRNTILKRRIQQGDVQPKGPCRELK 338
            ||.|.   .||.|..:|...|.|.||..:.|                              |.|:
  Rat   281 SALVSLSRSCPVCCKSFATKANVRRHFDEVH------------------------------RGLR 315

  Fly   339 RLQLSDDVVGYVPEPL-----------------DASGEHRKIMSLCIYCEKSFERRAALSTHLLN 386
            |..::.|:.....:||                 .:..|:......|:.|::.:..:..|..|:
  Rat   316 RDSITPDIATKPGQPLFLDSASPKKSFKTRKQKSSKAEYNLTACKCLLCKRKYSSQIMLKRHM-- 378

  Fly   387 CRAKQEALAKPAPSVKKLKMKSNDSSVDAADEDPTTSIDLPKKKPIKTEEITLNEMFADLPEPND 451
                        ..|.|:.:...:|..:....:...|.::..|                 .||.|
  Rat   379 ------------QIVHKITLSGANSKREKGPNNTANSSEVKVK-----------------VEPGD 414

  Fly   452 SFAPGLHTVSLDQLNLGNVSDSASDEASNTDDEHELTPGAGPESN---ADAEDVK-------GKA 506
            |.          :.:..:::.|..:|...|:..:|.......:.|   .|:|..|       |..
  Rat   415 SV----------ESSPPSITHSPQNELKGTNHSNEKKNTPATQKNKVKQDSESPKSASPSAAGGQ 469

  Fly   507 KKKRNVPVE-----KQLRCRCKICHKQFNALGNLRRHISMF----HYRARRFGCNLCEYRAFRRY 562
            :|.|...:.     |||  .||:|.:||.:..||.:||.:.    :...:.:.|.||.|...|:.
  Rat   470 QKTRKPKLSAGFDFKQL--YCKLCKRQFTSKQNLTKHIELHTDGNNIYVKFYKCPLCTYETRRKR 532

  Fly   563 DIVNHLGFTHKIEGDRDQLTEQYVSTHECEYSRDDVDGDIILLDKEEELTVMEKDAK-------- 619
            |::.|:...||   ...:...:..::.|....:..:|   .:|:|..:......:||
  Rat   533 DVIRHITVVHK---KSSRYLGKITASLEIRAIKKPID---FVLNKVAKRGPSRDEAKHNDSKHDG 591

  Fly   620 ---PPIKTYERRLKHLKTLTESVG-EVQ----------PKSPTAAIKEEPGQEPLEGTPTPSKKR 670
               .|.|.||         ...|| ||:          .|...|..|:...:.        .||.
  Rat   592 TSNSPSKKYE---------VADVGIEVKVTKNFSLHRCNKCGKAFAKKTYLEH--------HKKT 639

  Fly   671 RKSRTQISPESGEHSQEKRPIRKRVKAVNKDFVYDLVSFKPDGSCQQPPGA----QAVESMRAKL 731
            .|:....||| |..::.:....|.:..:.|.........:|      |.||    ||..|.||||
  Rat   640 HKANATTSPE-GNKTKGRSTRSKALVCLAKPSPRSAAILRP------PAGAVTTRQAASSCRAKL 697

  Fly   732 RRPA 735
            |..|
  Rat   698 RGAA 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10979	NP_001262301.1	C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..300	CDD:275368	7/16 (44%)
		C2H2 Zn finger	522..543	CDD:275368	9/24 (38%)
Zfp800	XP_038964031.1	zf-C2H2_11	355..383	CDD:406917	5/41 (12%)
		zf-C2H2_assoc2	391..485	CDD:406919	18/120 (15%)
		C2H2 Zn finger	488..508	CDD:275370	9/19 (47%)
		C2H2 Zn finger	521..540	CDD:275370	7/18 (39%)
		C2H2 Zn finger	618..640	CDD:275369	5/29 (17%)
		zf-C2H2	618..640	CDD:395048	5/29 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCDC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I4952
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007890
OrthoInspector	1	1.000	-	-		oto97369
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21020
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.940