DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10979 and CG18265

DIOPT Version :9

Sequence 1:	NP_001262301.1	Gene:	CG10979 / 40720	FlyBaseID:	FBgn0037379	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001261984.1	Gene:	CG18265 / 39947	FlyBaseID:	FBgn0036725	Length:	1322	Species:	Drosophila melanogaster

Alignment Length:	1108	Identity:	210/1108 - (18%)
Similarity:	340/1108 - (30%)	Gaps:	391/1108 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 CKVCRNMFRSLANFISHKR----VFCCV-SARSANGSGYTDQNSTMII----QTGGGPSPQDIEH 122
            |::|...|.:.....:||.    :|..| .:.|:|.|.:.:.|:..|.    .|.|.|:|.
  Fly   378 CELCNKEFCNKYFLKTHKANKHGIFDPVGESSSSNTSSHHNNNNNNITSSNNNTSGHPNPS---- 438

  Fly   123 MLRSRSTGCSPVPRDVRPLRGG---GGGGIRDLSGV-----------IERLRREK-------ATS 166
              .|..:....:.||.:..:..   .||....::.|           |..:||.:       |.:
  Fly   439 --MSSMSQMFQLQRDAQVAKQDPTPAGGASNPVASVHCDICSKRFTNIFAMRRHRAKQHEAQAAA 501

  Fly   167 QAKCSSPTVLQLESVPNSSQAVYQ-TIK--VDHDDSIRT-ELDEVHR---MLNPSE-TIVGPDGK 223
            |...:|.|.:|.:|...|.....| |||  :..|..|:. :|.|..|   .|...| :.|.|..|
  Fly   502 QVSPNSQTPMQSQSHRGSPNEPSQPTIKQEMSQDAEIKPYQLPEGFREDFTLEQEELSFVPPPRK 566

  Fly   224 A---LATVKLENNAGSDS----GEQSISDETEPSIFCEICNLTFQTHKTLEVHIQKHHS------ 275
            .   |.....::|...|.    |.|.      |..|||:|...:.....|..|..|.|.
  Fly   567 LPSHLQQQAKDSNFNPDKLRRLGVQF------PDFFCELCCREYANRYFLRTHKWKRHGLFVPPE 625

  Fly   276 --------------SSAFVFQCPACSLTFLQAAAVIR---------HLSKDHKKPTRRIRMMRNT 317
                          :||:.|.  ..:|...:|||...         .:..|.::|::||
  Fly   626 DVAPQPGSKDEAQMASAWPFM--PLNLMLAKAAAATMDQQEQEREPEVETDSEQPSKRI------ 682

  Fly   318 ILKRRIQQGDVQPKG-----------PCRELKRLQLS----DDVVGYVPEPLDASGEHRKIMSLC 367
                :::||...|:|           ..:.|::||..    :|:.|..|.|             |
  Fly   683 ----KLEQGQTPPEGYDEDKLNGSVVGLQNLQKLQSMLQQLNDINGKRPLP-------------C 730

  Fly   368 IYCEKSFERRAALSTHLLNCRAKQEALAKPAPSVKKLKMKSNDSSVDAADED---PTTSI----D 425
            ..|.:..|.:..|..||:...|.|..:..|.|             :...|:.   |..|:    .
  Fly   731 HLCGQEQENQYTLRAHLMTEHAGQMQMPMPIP-------------IPLPDQQAPHPMASLYHGQG 782

  Fly   426 LPKKKPIKTE------EITLNEMFADLPEPNDSFAPGLHTVSLDQLNLGNVSDSASDEASNTDDE 484
            .|:..|....      ::...:...|...|.: |...:..|.|.:  .|.:|.|...|...| .|
  Fly   783 NPQTPPAPGARSPPGCDLRCQQCDRDFATPQE-FKQHIAEVHLGR--NGGLSGSPLREGFFT-PE 843

  Fly   485 HELTPGAG-------PESNADAEDVKGKAKKKRNVPVEKQLRCRCKICHKQFNALGNLRRHISMF 542
            ..:.|.||       |.:|.....:         .|....    |:||:|:......::.|:...
  Fly   844 RPVAPSAGGPGTPVAPAANRPPYTL---------TPTSSY----CEICNKELCNKYFMKTHMQRM 895

  Fly   543 H----YRARRFG---CNLCEYRAFRRYDIVNHLGFTHKI----------EGDRDQLTEQYVSTHE 590
            |    ....:.|   ||:|......:|.:..|...||.|          .|......:...:...
  Fly   896 HGIEIENGAQIGGVVCNICNKELCSKYFLRVHKHNTHGIIEEGSPLPQPRGQNGVKADAAAAVAA 960

  Fly   591 CEYSRDDVDGDIILLDKEEELTVMEKDAKPP-----------------------IKTYE------ 626
            .:.|:...|.|:              :..||                       .::::
  Fly   961 SQPSQAQQDQDL--------------NVSPPTVEGSGGSSSNSAHEVCPLCSRQFRSFKWLRSHL 1011

  Fly   627 ---------RRLKHLKTLTESVGEVQPKSPTAAIKEEPGQEP-----LEGTPTPSKKRRKSRTQI 677
                     .||:.:.| |:|....:|.|||..|....|..|     ..|...|:..:.......
  Fly  1012 MNEHGTAGVERLREMDT-TQSSTRSKPNSPTLKIPNGSGSNPGAAGAGAGNTAPNLAQALQNLNA 1075

  Fly   678 SPESGEHSQEKRPIRKRVKAVNKDFVYDLVSFKPDGSCQQPPGAQAVESMRAKLRRPAPVGNDES 742
            ....|:..|::.|                         :.||           |..|...|...:
  Fly  1076 QHIFGQMQQQQIP-------------------------KMPP-----------LPLPGMFGEQSA 1104

  Fly   743 KAKQYEAYI------------TEEKKHLVFGITRRIMLELVSQGLAVSATLPELPSERPQIRPRL 795
            :.|:|:..:            ..|:.|        .:|....:||       |||.|.|..:|
  Fly  1105 RFKEYQCSLCPFSTPYYAFLFIHERSH--------ALLNNGGEGL-------ELPMETPPPQP-- 1152

  Fly   796 ISHSRSESGSQQKQNIVETTVDPAP----ETESFIE---------KIAKRTAAAGKDNAVISNLW 847
               |||...|:.|.:  ::.|.|.|    |||..:|         |:|.|:.:.|..:...|:
  Fly  1153 ---SRSSGKSRSKSS--KSMVAPPPAKSEETEPPLEPTNLSTSAPKVASRSPSTGAGSPPASS-- 1210

  Fly   848 NKVNTAIAQQEKQQKKEQEPLQEAQPEEKSETEKSKSPLQAPSPPSPPS-ICEATVPETLATTGM 911
                               |...:....|.:..:|.|     .||:.|: :..||.....|.|..
  Fly  1211 -------------------PKATSSTSPKIQRRRSTS-----KPPTTPNGLGSATGGHRSAATSP 1251

  Fly   912 -----DCLRGKGSQA------GASTVF-------------------PSLPKPPSVLQAAANGTIQ 946
                 :...|.|..|      ||...:                   |:|...|..::|:.:.|:.
  Fly  1252 FEGCGELANGIGKPASYAQPDGAEEAYQMQAFHLQPADQDSEMQFAPALVYLPVRVRASESATLS 1316

  Fly   947 FTL 949
            |.|
  Fly  1317 FRL 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10979	NP_001262301.1	C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..300	CDD:275368	4/25 (16%)
		C2H2 Zn finger	522..543	CDD:275368	5/20 (25%)
CG18265	NP_001261984.1	PHA03377	<1169..>1316	CDD:177614	32/172 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5550
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030