DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10979 and Zfy1

DIOPT Version :9

Sequence 1:	NP_001262301.1	Gene:	CG10979 / 40720	FlyBaseID:	FBgn0037379	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_033596.3	Gene:	Zfy1 / 22767	MGIID:	99212	Length:	782	Species:	Mus musculus

Alignment Length:	735	Identity:	153/735 - (20%)
Similarity:	261/735 - (35%)	Gaps:	190/735 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 QLESVPNSSQAVYQTIKVD--HDDS--IRTELDEVHRMLNPSETIVG--PD--GKALATVKLENN 233
            ::|..|...::.:..|..|  |.||  |..|:.|...:.|...|:..  ||  |..:....:||.
Mouse     5 EIELTPEEEKSFFDGIGADAVHMDSDQIVVEVQETVFLANSDVTVHNFVPDNPGSVIIQDVIENV 69

  Fly   234 AGSDSGEQSISDETEPSIFCEICNLTFQTHKTLEVHIQKHHSSSAFVFQCPACSLTF----LQAA 294
            ...|.....|.:||:.|....|...........||.:.:............:.|||.    |.:.
Mouse    70 LIEDVHCSHILEETDISDNVIIPEQVLNLGTAEEVSLAQFLIPDILTSGITSTSLTMPEHVLMSE 134

  Fly   295 AVIRHLSK-DHKKPTRRIRMMRNTILKRRIQQGDVQPKGPCRELKRLQLSDDVVGYVPEPLDASG 358
            |:  |:|. .|.:     :::.:::::..:....:     ..:...:.::|.|...|   ||:||
Mouse   135 AI--HVSDVGHFE-----QVIHDSLVETEVITDPI-----TADTSDILVADCVSEAV---LDSSG 184

  Fly   359 -------------EHRKIMSLCIYCEKSFERRAALSTHLLNCRAKQEA--LAKPAPSVKKLKMKS 408
                         |...:|||....:...|..:.::   :|..:..::  |.:.:|.|.|:.:..
Mouse   185 MPLEQQDNDKINCEDYLMMSLDEPSKADLEGSSEVT---MNAESGTDSSKLDEASPEVIKVCILK 246

  Fly   409 NDSSVDAADE------------------DPTTSIDLPK-----------KKPIKTEEITLNE--- 441
            .||.||...|                  |.:|||.:|:           |:...||.|..:|
Mouse   247 ADSEVDELGETIHAVESETKNGNEAEVTDQSTSIRVPRVNIYMSASDSQKEEEDTEVIVGDEDAG 311

  Fly   442 -MFADLPEPND---------SFAPGLHTVSLDQLNLGNVSDSASDE---AS---NTDDEHELTPG 490
             ..||.||...         :|.|...|.:.|     |.||...|:   ||   |.|
Mouse   312 GTAADTPEHEQQMDVSEIKAAFLPIAWTAAYD-----NNSDEIEDQNVTASALLNQD-------- 363

  Fly   491 AGPESNADAEDVKGKAKKKRNVPVEKQLRCR--------------CKICHKQFNALGNLRRHISM 541
               ||.......|.|:|||:. |..||.:..              |..|.|:|.....|:||...
Mouse   364 ---ESGGLDRVPKQKSKKKKR-PESKQYQSAIFVAPDGQTLRVYPCMFCGKKFKTKRFLKRHTKN 424

  Fly   542 F-HYRA-RRFGCNLCEYRAFRRYDIVNHLGFTHKIEGDRDQLTEQYVSTHECEYSRDDVDGDIIL 604
            . .|.| :::.|..|:|...::..:.||:. :||       ||.:...|.||:..|.::.....|
Mouse   425 HPEYLANKKYHCTECDYSTNKKISLHNHME-SHK-------LTIKTEKTTECDDCRKNLSHAGTL 481

  Fly   605 LDKEEELTVMEKDAKPPIK-------TYERRL-------KHLKTLTESVGEV-----QPKSPTAA 650
            ...:...|  ||......|       |.|:.|       .|.|......||.     .|.:....
Mouse   482 CTHKTMHT--EKGVNKTCKCKFCDYETAEQTLLNHHLLVVHRKKFPHICGECGKGFRHPSALKKH 544

  Fly   651 IKEEPGQEPLEGTPTPSKKRRKSRTQISPESGEHSQEKRPIRKRVKAVNKDFVYDLVSFKPDGSC 715
            |:...|::|.|......|....|..:...:| :||:| .|::..:         .|::|..:...
Mouse   545 IRVHTGEKPYECQYCEYKSADSSNLKTHIKS-KHSKE-IPLKCGI---------CLLTFSDNKEA 598

  Fly   716 QQPPGAQAVESMRAKLRRPAPVGNDESKAKQYEAYITEEKKHLVFGITRRI--MLELVSQGLAVS 778
            ||    .||....::..:.:...:..|.:       ::.|:|::...|:..  ..::.|:|.
Mouse   599 QQ----HAVLHQESRTHQCSHCNHKSSNS-------SDLKRHIISVHTKAYPHKCDMCSKGF--- 649

  Fly   779 ATLPELPSERPQIRPRLISH 798
                ..|||   ::..:.:|
Mouse   650 ----HRPSE---LKKHVATH 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10979	NP_001262301.1	C2H2 Zn finger	253..273	CDD:275368	3/19 (16%)
		C2H2 Zn finger	283..300	CDD:275368	5/20 (25%)
		C2H2 Zn finger	522..543	CDD:275368	7/21 (33%)
Zfy1	NP_033596.3	Zfx_Zfy_act	68..388	CDD:282547	75/354 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..386		10/37 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	372..382		5/10 (50%)
		C2H2 Zn finger	405..425	CDD:275370	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275370	5/20 (25%)
		C2H2 Zn finger	468..488	CDD:275368	3/19 (16%)
		C2H2 Zn finger	499..520	CDD:275368	3/20 (15%)
		COG5048	<513..687	CDD:227381	32/182 (18%)
		zf-C2H2	526..548	CDD:278523	4/21 (19%)
		C2H2 Zn finger	528..548	CDD:275368	4/19 (21%)
		zf-H2C2_2	540..562	CDD:290200	4/21 (19%)
		C2H2 Zn finger	556..577	CDD:275368	3/21 (14%)
		C2H2 Zn finger	585..605	CDD:275368	6/32 (19%)
		C2H2 Zn finger	613..634	CDD:275368	3/27 (11%)
		C2H2 Zn finger	642..691	CDD:275368	6/31 (19%)
		C2H2 Zn finger	699..719	CDD:275368
		zf-H2C2_2	711..735	CDD:290200
		C2H2 Zn finger	727..748	CDD:275368
		C2H2 Zn finger	756..776	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000