DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10979 and znf800

DIOPT Version :9

Sequence 1:	NP_001262301.1	Gene:	CG10979 / 40720	FlyBaseID:	FBgn0037379	Length:	959	Species:	Drosophila melanogaster
Sequence 2:	NP_001120895.1	Gene:	znf800 / 100151720	XenbaseID:	XB-GENE-1217280	Length:	690	Species:	Xenopus tropicalis

Alignment Length:	788	Identity:	166/788 - (21%)
Similarity:	269/788 - (34%)	Gaps:	272/788 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RSSRCNSDTFKEEQMDHNG----------DDISLLQRPLRTAHTGFEEARRAYEDGTSEVRQLLS 58
            |...|.:|      ..|:|          .|..|||:|::|:.:|..:....:..||.:::.:|.
Frog    37 RDKYCQTD------HHHHGCCETAITLEPGDPPLLQQPVQTSRSGILQIIECFRSGTKQLKHMLL 95

  Fly    59 LECSLIYECKVCRNMFRSLANFISHKRVFCCVSARSANGSGYTDQNSTMIIQTGGGPSPQDIEHM 123
            .|...|:|||.||::||.|.|.|:||:.:|....                             ||
Frog    96 KEVDTIFECKSCRSLFRGLPNLITHKQFYCLSKL-----------------------------HM 131

  Fly   124 LRSRSTGCSPVPRDVRPLRGGGGGGIRDLSGVIERLRREKATSQAKCSSPTVLQLESVPNSSQAV 188
            ....||      .:.:|     |..::||...|    ..||.     .|..|:|||.:..:..||
Frog   132 EECPST------ENDKP-----GQEMKDLLETI----YPKAD-----KSELVIQLEPIQTNKNAV 176

  Fly   189 YQTI-------KVDHD----DSIRTELDEVHRMLNPSETIVGPDGKALATVKLENNAGSDSGEQS 242
            :|.:       .|:|.    |....::.|.    .||.||..|..:.......:|:....|...|
Frog   177 FQYVTTAAEISTVNHSPPDPDPGEVQVTET----VPSTTISAPQTEMNEQPPSDNSKKEPSSSIS 237

  Fly   243 ISDETEPSIF---------------CEICNLTFQTHKTLEVHIQKHH------------------ 274
            :....:...|               |.:|...|...:::..||:|.|
Frog   238 VESPVQTISFVPKPIKTVSSSHPFSCRVCKKAFTCRRSIRRHIKKVHRKKLEDIKKFIEVQRIPK 302

  Fly   275 -----------SSSAFVFQCPACSLTFLQAAAVIRHLSKDHKKPTRRIRMMRNTILKRRIQQGDV 328
                       ||::    |..|..:|...|.|.||:.:.||...|...:...|....:....::
Frog   303 LSKGRKRVHTTSSNS----CHVCHKSFATKANVRRHIDEVHKGMRRDSSIPEVTAKPGKTSASEI 363

  Fly   329 -QPKGPCRELKRLQLSDDVVGYVPEPLDASGEHRKIMS--LCIYCEKSFERRAALSTHLLNCRAK 390
             .||...:.|.|        |..|     ||:....:|  .|.||::.:..|..|..|:   ...
Frog   364 SSPKKTVKSLPR--------GQKP-----SGKSDFSLSSCKCPYCKRRYTSRYLLKKHI---HIV 412

  Fly   391 QEALAKPAPSVKKLKMKSNDSSVDAADEDPTTSIDLPKKKPIKTEEITLNEMFADLPEPNDSFAP 455
            .:|:.. ....|:.|.:::.::.|.               .:|||
Frog   413 HKAMVS-GKDCKQAKERNHAANADV---------------KVKTE-------------------- 441

  Fly   456 GLHTVSLDQLNLGNVSDSASDEASNTDDEHELTPGAGPESNADAEDVKGKA--KKKRNVPV---- 514
            .|:||....:.:.|.|:|....|.:.:::..:......::.:|||..|...  |||...|.
Frog   442 SLNTVEPSTITVSNSSNSELKGAHSANEKKSIPAAQKSKAKSDAESPKASPGDKKKFKKPKLSAG 506

  Fly   515 --EKQLRCRCKICHKQFNALGNLRRHISMF----HYRARRFGCNLCEYRAFRRYDIVNHLGFTHK 573
              .|||  .||:|.:||.:..||.:||.:.    :...:.:.|.||.|...|:.|::.|:...||
Frog   507 FDFKQL--YCKLCKRQFTSKQNLTKHIELHTDGNNIYVKFYRCPLCSYETRRKRDVIRHITVVHK 569

  Fly   574 IEGDRDQLTEQYVSTHECEYSRDDVDGDIILLDKEEELTV-----MEKDA-KPPIKTYERRLKHL 632
                                             |.:...|     :|..| |.||:|.
Frog   570 ---------------------------------KSQRALVKITANLESRAIKKPIETI------- 594

  Fly   633 KTLTESVGEVQPKSPTAAIKEEPGQEPLEG---TPTPSKKRRKSRTQISPESGEHSQEKRPIRKR 694
                  :.:|..|:|.   ||:..|..|:.   :|:|:||.         .:||.|.|.:
Frog   595 ------LDKVMKKAPQ---KEKSKQLTLKQDGISPSPNKKH---------NAGEASIEVK----- 636

  Fly   695 VKAVNKDF 702
               |.|.|
Frog   637 ---VTKSF 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10979	NP_001262301.1	C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..300	CDD:275368	6/16 (38%)
		C2H2 Zn finger	522..543	CDD:275368	9/24 (38%)
znf800	NP_001120895.1	C2H2 Zn finger	263..311	CDD:275368	7/47 (15%)
		C2H2 Zn finger	318..335	CDD:275368	6/16 (38%)
		zf-C2H2_11	387..414	CDD:293228	7/29 (24%)
		zf-C2H2_assoc2	422..511	CDD:293230	21/123 (17%)
		C2H2 Zn finger	514..534	CDD:275370	9/19 (47%)
		C2H2 Zn finger	547..566	CDD:275370	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007890
OrthoInspector	1	1.000	-	-		oto104051
Panther	1	1.100	-	-	LDO	PTHR21020
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5550
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.040