DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1218 and Hpf1

DIOPT Version :9

Sequence 1:	NP_649589.1	Gene:	CG1218 / 40718	FlyBaseID:	FBgn0037377	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_001162576.1	Gene:	Hpf1 / 290706	RGDID:	1311747	Length:	351	Species:	Rattus norvegicus

Alignment Length:	339	Identity:	124/339 - (36%)
Similarity:	173/339 - (51%)	Gaps:	35/339 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 IRLSVQKEYDNLCESNEFIRHKFLVEMPPDFYEFWKFVGSLKIDPAKPKDAGLEHLDKVFQLQLV 180
            ::.|...|.|...:..:.:.|.:.:.:|.|||.||||...|  ||.||.||    |.....|:||
  Rat    23 VKKSKSSEADISSDLRKEVEHLYKLSLPEDFYHFWKFCEEL--DPEKPADA----LATSLGLRLV 81

  Fly   181 GPFEFLAGKFHGAKLGEPG-DYLRHWRFYYDPPEFQTIFV-RRGTGIHYGYWRDVPQDKENLLIA 243
            ||::.|||| |..|....| :...||||||||||||||.: ...|..|.||:||.| |:..:.:.
  Rat    82 GPYDILAGK-HKMKKNPTGLNCNLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSP-DELPVYVG 144

  Fly   244 RNDSAKGCQFQFVAGNAFDAFLYYLEHDFAATPFSCGQLAGTKK-AVAKYLSDNSLE-------- 299
            .|::.|.|.......|.|.|...:|.....       ::...|| ::.|.:.:...|
  Rat   145 TNEAKKNCIIIQNGDNVFAAIKLFLMKKLK-------EVTDRKKISILKNIDEKLTEAARKLGYS 202

  Fly   300 LAQLDRLQRERNKRVVAKTFHRAGIVVPFDQKTEVGYRPLAVSDSELKKMLAMLERKDVDNGAAK 364
            |.|.....|:|:|:||.||||.||:|||.| |.:||||.|..:|::|||:.     |.:.:.|:.
  Rat   203 LEQRTVKMRQRDKKVVTKTFHGAGLVVPVD-KNDVGYRELPETDADLKKIC-----KAIVDAASD 261

  Fly   365 QAVLEKLQPVANA---ANIAVDESDFGSALELGIDMFCSGHKELHMLASSLLVPAYSMLSRPQFI 426
            :..|:...|:...   ...|.||.|:|..||||:|:||.|....|.:|..||..||::|.|..|.
  Rat   262 EERLKAFAPIQEMMTFVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPLAYNLLKRDLFA 326

  Fly   427 AIAKAHMEQRSRED 440
            .|.:.|:..||.||
  Rat   327 KIIEDHLASRSEED 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1218	NP_649589.1	zf-CCHH	4..25	CDD:287283
CG1218	NP_649589.1	DUF2228	178..428	CDD:287230	97/263 (37%)
Hpf1	NP_001162576.1	DUF2228	79..328	CDD:287230	97/263 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353844
Domainoid	1	1.000	142	1.000	Domainoid score	I4590
eggNOG	1	0.900	-	-		E1_KOG3952
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32374
Inparanoid	1	1.050	180	1.000	Inparanoid score	I3896
OMA	1	1.010	-	-		QHG49331
OrthoDB	1	1.010	-	-		D1077112at2759
OrthoFinder	1	1.000	-	-		FOG0007294
OrthoInspector	1	1.000	-	-		oto98034
orthoMCL	1	0.900	-	-		OOG6_106869
Panther	1	1.100	-	-	LDO	PTHR13386
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6180
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770