DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1218 and JC8.7

DIOPT Version :9

Sequence 1:	NP_649589.1	Gene:	CG1218 / 40718	FlyBaseID:	FBgn0037377	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_001255715.1	Gene:	JC8.7 / 186815	WormBaseID:	WBGene00010439	Length:	333	Species:	Caenorhabditis elegans

Alignment Length:	421	Identity:	96/421 - (22%)
Similarity:	157/421 - (37%)	Gaps:	122/421 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SQSGEQKKEEQTEPVNKDKSNTSASSTEMVNKDTAKGSYEAETEELHKEAMSNISGKNYMEILEK 114
            ::.|.::|      |:||:.||: ...||..|...|.....|.:.:...|:.....:|:.||:|
Worm     2 AKRGRKRK------VSKDEENTT-PEPEMKKKADEKVVELDEKDWMPSAALEFFENENFKEIVE- 58

  Fly   115 RIRLSVQKEYDNLCESNEFIRHKFLVEMPPDFYEFWKFVGSLKIDPAKPKDAGLEHLDKVFQLQL 179
                                                                .|.|||.  .:.|
Worm    59 ----------------------------------------------------NLSHLDN--SVTL 69

  Fly   180 VGPFEFLAGKFHGAKLGEPGDYLRHWRFYYDPPEFQTIFVRRGTGIHYGYWRDVPQDKENLLIAR 244
            ||||.    |..|....:..|.:...|...|.||.|| |::...| .|.:|||.|.||:.:::..
Worm    70 VGPFR----KLRGESDADGTDLIMLDREMTDLPEMQT-FMKCSHG-RYAFWRDKPNDKKPVIVFM 128

  Fly   245 NDSAKGCQFQFVAGNAFDAFLYYLEH---DFAATPFSCGQLAGTKKA----VAKYLSDNSLELAQ 302
            :  .|......|.||.       :.|   ||......|...:...||    :..:.:.:.:. ::
Worm   129 D--LKTIPDLSVVGNE-------IRHAILDFCTRCSKCIDCSAKSKAANSKIQSFFTPSKIS-SE 183

  Fly   303 LDRLQRERNKRVVAKTFHRAGI--------VVPF------DQKTE-VGYRPLA-----VSDSELK 347
            :..:.:.|.|..|      .||        |||.      ::|.| .|||.|:     ::...|.
Worm   184 VKEVLKHREKTTV------RGISGPGMLIDVVPTGNSGKKNKKNERTGYRDLSKNAYCINIEHLV 242

  Fly   348 KMLAMLERKDVDNGAAKQAVLEKLQPVANAANIAVDESDFGSALELGIDMFCSGHKELHMLASSL 412
            :.|.:.:.|:     .::.||:.:..:.|..||..||.|||:.||||..:|.:..|   .:|..:
Worm   243 RSLRLCQTKE-----QEEKVLDFVYGLMNEINICNDEGDFGNGLELGHILFLANMK---AVADPM 299

  Fly   413 LVP---AYSMLSRPQFIAIAKAHMEQRSRED 440
            ::.   ||..|.||.|..|....:..|.:::
Worm   300 MITLHIAYKNLHRPDFAKILDLTLSLRDQQE 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1218	NP_649589.1	zf-CCHH	4..25	CDD:287283
CG1218	NP_649589.1	DUF2228	178..428	CDD:287230	73/279 (26%)
JC8.7	NP_001255715.1	DUF2228	69..318	CDD:287230	73/278 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167316
Domainoid	1	1.000	57	1.000	Domainoid score	I7301
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I3997
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49331
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007294
OrthoInspector	1	1.000	-	-		oto17660
orthoMCL	1	0.900	-	-		OOG6_106869
Panther	1	1.100	-	-	LDO	PTHR13386
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4808
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.930