DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn5 and Psmd12

DIOPT Version :9

Sequence 1:	NP_649588.1	Gene:	Rpn5 / 40717	FlyBaseID:	FBgn0028690	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_080170.1	Gene:	Psmd12 / 66997	MGIID:	1914247	Length:	456	Species:	Mus musculus

Alignment Length:	496	Identity:	236/496 - (47%)
Similarity:	326/496 - (65%)	Gaps:	59/496 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GRITKMEVDYEPACNEKIPLAKELAKKNPDAFHEAIEMMLQLEKQTRLGADMVSCSRVLVAICQI 73
            |||.||||||....::::|..::|||:.  ...|.||.:|.||||||..:||||.||:|||:.::
Mouse    11 GRIVKMEVDYSATVDQRLPECEKLAKEG--RLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKM 73

  Fly    74 CFDASNWNALNEYVSLLVRRRSQLKQAVVKMIQECVTYVDKTPDKETKLKLIDTLRSVTEGKIYV 138
            |::|..|:.|||.:.||.:|||||||||.||:|:|.|||::..|...||:||||||.||||||||
Mouse    74 CYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYV 138

  Fly   139 EIERARLTKILADIKEADGDVAGAATVMEELQVETYGSMDKREKVELILEQMRLCLLKEDYVSTQ 203
            |||||||||.||.|||.:|||..||::::||||||||||:|:|:||.|||||||||..:||:.||
Mouse   139 EIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQ 203

  Fly   204 IIAKKISIKFFDDPAQHDLKLKFYYLMIQLNR-DTSFLNTSRHYQAIAEPPRKKTGLTPVDSAAS 267
            ||:|||:.|||.:....:||||:|.|||||:: :.|:|:..:||:||.:        ||...|
Mouse   204 IISKKINTKFFQEENTENLKLKYYNLMIQLDQHEGSYLSICKHYRAIYD--------TPCIQA-- 258

  Fly   268 TDEQKKKDDDKKKKEEDDKDKKPEVATEAEVEIELTEEQKKELTEKLVCAVLYCVLAPFDNEQSD 332
                           |.||                       ..:.|...|||.:||||||||||
Mouse   259 ---------------ESDK-----------------------WQQALKSVVLYVILAPFDNEQSD 285

  Fly   333 MMAHLSKNKKLEEVPAYKEILRLFMSKELINFDTFNADFGLVLAE-------NEMFKDSTKHGKK 390
            ::..:|.:|||||:|.||::|:||.:.||:.:.|...|:|:.|.:       .::| .||:.|:|
Mouse   286 LVHRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKGSSETPATDVF-SSTEEGEK 349

  Fly   391 CITELKDRLIEHNIRIIAMYYSRLHLARMSELLNLPTSRCEEYLSKLANTDTIRVKIDRPAGIIY 455
            ...:||.|::||||||:|.||:|:.:.||::||:|.....|.:||.|....||..|:||.||:|.
Mouse   350 RWKDLKSRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVIN 414

  Fly   456 FTQKKSASDILNNWATDVNQLMSLVNKTCHLINKEECVYSV 496
            |.:.|..:::||:|:..:|.||||||||.|||.|||.::::
Mouse   415 FQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNL 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn5	NP_649588.1	RPN5	13..496	CDD:227403	233/490 (48%)
Psmd12	NP_080170.1	RPN5	14..456	CDD:227403	233/493 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836110
Domainoid	1	1.000	300	1.000	Domainoid score	I1415
eggNOG	1	0.900	-	-		E1_COG5071
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2109
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1733
Isobase	1	0.950	-	0	Normalized mean entropy	S656
OMA	1	1.010	-	-		QHG54023
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003700
OrthoInspector	1	1.000	-	-		oto93289
orthoMCL	1	0.900	-	-		OOG6_102014
Panther	1	1.100	-	-	LDO	PTHR10855
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2265
SonicParanoid	1	1.000	-	-		X2567
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740